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    RBX1 RING-box 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832179, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RBX1
    Official Full Name
    RING-box 1
    Primary source
    TAIR:AT5G20570
    Locus tag
    AT5G20570
    See related
    Araport:AT5G20570
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATRBX1; F7C8.160; F7C8_160; HRT1; REGULATOR OF CULLINS-1; RING-box 1; RING-BOX 1; ROC1
    Summary
    Encodes a ring-box 1 like protein and component of the SCF ubiquitinization complex mediating auxin responses. Forms a E3 ubiquitin ligase complex with CUL3A and At1g21780.1 a BTB domain protein.
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    Genomic context

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    See RBX1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (6956573..6958338, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein Neighboring gene Glycosyl hydrolase superfamily protein Neighboring gene TMEM192 family protein Neighboring gene TRICHOME BIREFRINGENCE-LIKE 5 Neighboring gene ribosomal RNA processing-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new temperature-insensitive allele of the Arabidopsis AXR6/CUL1 locus derived from a missense mutation in the C-terminal RBX1 binding region. Mori Y, et al. Plant Signal Behav, 2015. PMID 26339842, Free PMC Article
    2. Role of the Arabidopsis RING-H2 protein RBX1 in RUB modification and SCF function. Gray WM, et al. Plant Cell, 2002 Sep. PMID 12215511, Free PMC Article
    3. The AtRbx1 protein is part of plant SCF complexes, and its down-regulation causes severe growth and developmental defects. Lechner E, et al. J Biol Chem, 2002 Dec 20. PMID 12381738
    4. Arabidopsis AXR6 encodes CUL1 implicating SCF E3 ligases in auxin regulation of embryogenesis. Hellmann H, et al. EMBO J, 2003 Jul 1. PMID 12839993, Free PMC Article
    5. The SCF(COI1) ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis. Xu L, et al. Plant Cell, 2002 Aug. PMID 12172031, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The axr6-101 phenotype is caused by the E716K substitution of the CUL1 protein, which is likely to affect its ability to bind to the C-terminal RING domain of RING-box 1 (RBX1).
      Title: A new temperature-insensitive allele of the Arabidopsis AXR6/CUL1 locus derived from a missense mutation in the C-terminal RBX1 binding region.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001161253.1
    NM_001161254.1
    NM_122064.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein ubiquitination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to auxin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    RING-box 1
    NP_001154725.1
    • RING-box 1 (RBX1); FUNCTIONS IN: protein binding; INVOLVED IN: response to auxin stimulus, protein ubiquitination; LOCATED IN: SCF ubiquitin ligase complex, Cul3-RING ubiquitin ligase complex; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; BEST Arabidopsis thaliana protein match is: RING/U-box superfamily protein (TAIR:AT3G42830.1); Has 1082 Blast hits to 1082 proteins in 219 species: Archae - 0; Bacteria - 0; Metazoa - 516; Fungi - 191; Plants - 169; Viruses - 3; Other Eukaryotes - 203 (source: NCBI BLink).
    NP_001154726.1
    • RING-box 1 (RBX1); CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841); BEST Arabidopsis thaliana protein match is: RING/U-box superfamily protein (TAIR:AT3G42830.1); Has 1088 Blast hits to 1088 proteins in 224 species: Archae - 0; Bacteria - 0; Metazoa - 498; Fungi - 214; Plants - 176; Viruses - 3; Other Eukaryotes - 197 (source: NCBI BLink).
    NP_568396.1
    • RING-box 1 (RBX1); CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841); BEST Arabidopsis thaliana protein match is: RING/U-box superfamily protein (TAIR:AT3G42830.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      6956573..6958338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122064.3 → NP_568396.1  RING-box 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568396.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q940X7
      UniProtKB/TrEMBL
      A0A178UAL4, A0A5S9Y6C1, A0A654G317
      Conserved Domains (1) summary
      cd16485
      Location:50 → 111
      mRING-H2-C3H2C2D_RBX1; modified RING finger, H2 subclass (C3H2C2D-type), found in RING-box protein 1 (RBX1) and similar proteins

    2. NM_001161253.1 → NP_001154725.1  RING-box 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154725.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9Y6C1, A0A654G317, F4K5K0
      Conserved Domains (2) summary
      pfam12678
      Location:31 → 132
      zf-rbx1; RING-H2 zinc finger
      cl17238
      Location:30 → 142
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    3. NM_001161254.1 → NP_001154726.1  RING-box 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154726.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9Y6C1, A0A654G317, F4K5K1
      Conserved Domains (2) summary
      COG5194
      Location:30 → 136
      APC11; Component of SCF ubiquitin ligase and anaphase-promoting complex [Posttranslational modification, protein turnover, chaperones / Cell division and chromosome partitioning]
      pfam12678
      Location:31 → 126
      zf-rbx1; RING-H2 zinc finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q940X7.1

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