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    RGP2 reversibly glycosylated polypeptide 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831419, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RGP2
    Official Full Name
    reversibly glycosylated polypeptide 2
    Primary source
    TAIR:AT5G15650
    Locus tag
    AT5G15650
    See related
    Araport:AT5G15650
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATRGP2; F14F8.30; F14F8_30; reversibly glycosylated polypeptide 2; REVERSIBLY GLYCOSYLATED POLYPEPTIDE 2
    Summary
    RGP2 is a UDP-arabinose mutase that catalyzes the interconversion between the pyranose and furanose forms of UDP-L-arabinose. It appears to be required for proper cell wall formation. rgp1(at3g02230)/rgp2 double mutants have a male gametophyte lethal phenotype. RGP2 fusion proteins can be found in the cytosol and peripherally associated with the Golgi apparatus. RGP2 was originally identified as Reversibly Glycosylated Polypeptide-2. Constitutive expression in tobacco impairs plant development and virus spread.
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    Genomic context

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    See RGP2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (5092140..5095302)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene COBRA-like extracellular glycosyl-phosphatidyl inositol-anchored protein family Neighboring gene Mitochondrial substrate carrier family protein Neighboring gene F-box and associated interaction domains-containing protein Neighboring gene F-box family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Cell Wall Arabinose-Deficient Arabidopsis thaliana Mutant murus5 Encodes a Defective Allele of REVERSIBLY GLYCOSYLATED POLYPEPTIDE2. Dugard CK, et al. Plant Physiol, 2016 Jul. PMID 27217494, Free PMC Article
    2. Arabidopsis reversibly glycosylated polypeptides 1 and 2 are essential for pollen development. Drakakaki G, et al. Plant Physiol, 2006 Dec. PMID 17071651, Free PMC Article
    3. Cloning and characterization of AtRGP1. A reversibly autoglycosylated arabidopsis protein implicated in cell wall biosynthesis. Delgado IJ, et al. Plant Physiol, 1998 Apr. PMID 9536051, Free PMC Article
    4. The interconversion of UDP-arabinopyranose and UDP-arabinofuranose is indispensable for plant development in Arabidopsis. Rautengarten C, et al. Plant Cell, 2011 Apr. PMID 21478444, Free PMC Article
    5. Mutants of Arabidopsis thaliana with altered cell wall polysaccharide composition. Reiter WD, et al. Plant J, 1997 Aug. PMID 9301086

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RGP2 cysteine-257 to tyrosine-257 mutation results in the cell wall arabinose deficient Arabidopsis and affects protein stability.
      Title: The Cell Wall Arabinose-Deficient Arabidopsis thaliana Mutant murus5 Encodes a Defective Allele of REVERSIBLY GLYCOSYLATED POLYPEPTIDE2.
    2. RGP2 is required during microspore development and pollen mitosis, either affecting cell division and/or vacuolar integrity.
      Title: Arabidopsis reversibly glycosylated polypeptides 1 and 2 are essential for pollen development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_121569.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables UDP-arabinopyranose mutase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables intramolecular transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within UDP-L-arabinose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within arabinose biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plant-type cell wall biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plant-type cell wall organization or biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pollen development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in cytosolic ribosome HDA PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type cell wall HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    reversibly glycosylated polypeptide 2
    NP_197069.1
    • reversibly glycosylated polypeptide 2 (RGP2); FUNCTIONS IN: transferase activity, transferring hexosyl groups, glycogenin glucosyltransferase activity; INVOLVED IN: response to cadmium ion, response to salt stress; LOCATED IN: cytosolic ribosome, cell wall, membrane; EXPRESSED IN: male gametophyte, guard cell, root, cultured cell, leaf; EXPRESSED DURING: seedling growth, seed development stages; CONTAINS InterPro DOMAIN/s: Alpha-1,4-glucan-protein synthase, UDP-forming (InterPro:IPR004901); BEST Arabidopsis thaliana protein match is: reversibly glycosylated polypeptide 1 (TAIR:AT3G02230.1); Has 259 Blast hits to 255 proteins in 45 species: Archae - 24; Bacteria - 8; Metazoa - 0; Fungi - 0; Plants - 223; Viruses - 0; Other Eukaryotes - 4 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      5092140..5095302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121569.3 → NP_197069.1  reversibly glycosylated polypeptide 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197069.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22428, Q8LB19, Q9LFW1
      UniProtKB/TrEMBL
      A0A178UG61, A0A384L2V5, W8QN98
      Conserved Domains (1) summary
      PLN03180
      Location:12 → 355
      PLN03180; reversibly glycosylated polypeptide; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LFW1.1

    Gene LinkOut

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