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    PEX1 peroxisome 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830746, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PEX1
    Official Full Name
    peroxisome 1
    Primary source
    TAIR:AT5G08470
    Locus tag
    AT5G08470
    See related
    Araport:AT5G08470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    EMB2817; EMBRYO DEFECTIVE 2817; F8L15.15; peroxisome 1
    Summary
    an AAA-ATPase that is the probable Arabidopsis orthologue of one of the AAA-ATPases involved in peroxisome biogenesis in yeasts and mammals.
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    Genomic context

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    See PEX1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    18
    Sequence:
    Chromosome: 5; NC_003076.8 (2735911..2743065)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH domain protein Neighboring gene GDSL-like Lipase/Acylhydrolase superfamily protein Neighboring gene VQ motif-containing protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene Transmembrane CLPTM1 family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The PEX1 ATPase Stabilizes PEX6 and Plays Essential Roles in Peroxisome Biology. Rinaldi MA, et al. Plant Physiol, 2017 Aug. PMID 28600347, Free PMC Article
    2. A pex1 missense mutation improves peroxisome function in a subset of Arabidopsis pex6 mutants without restoring PEX5 recycling. Gonzalez KL, et al. Proc Natl Acad Sci U S A, 2018 Apr 3. PMID 29555730, Free PMC Article
    3. Arabidopsis ABERRANT PEROXISOME MORPHOLOGY9 is a peroxin that recruits the PEX1-PEX6 complex to peroxisomes. Goto S, et al. Plant Cell, 2011 Apr. PMID 21487094, Free PMC Article
    4. Functional classification of Arabidopsis peroxisome biogenesis factors proposed from analyses of knockdown mutants. Nito K, et al. Plant Cell Physiol, 2007 Jun. PMID 17478547
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. beyond PEX5 recycling, PEX1 and PEX6 have additional functions in peroxisome homeostasis and perhaps in oil body utilization
      Title: A pex1 missense mutation improves peroxisome function in a subset of Arabidopsis pex6 mutants without restoring PEX5 recycling.
    2. genetic, molecular, and physiological data support the heterohexamer model of PEX1-PEX6 function in plants.
      Title: The PEX1 ATPase Stabilizes PEX6 and Plays Essential Roles in Peroxisome Biology.
    3. PEX1 and PEX6 comprise a heterooligomer and this complex was recruited to peroxisomal membranes via protein-protein interactions of APEM9 with PEX6.
      Title: Arabidopsis ABERRANT PEROXISOME MORPHOLOGY9 is a peroxin that recruits the PEX1-PEX6 complex to peroxisomes.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001343003.1
    NM_001343004.1
    NM_001343005.1
    NM_120932.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid beta-oxidation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peroxisome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein import into peroxisome matrix IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    peroxisome 1
    NP_196464.2
    • peroxisome 1 (PEX1); FUNCTIONS IN: nucleoside-triphosphatase activity, ATPase activity, binding, nucleotide binding, ATP binding; INVOLVED IN: protein import into peroxisome matrix, fatty acid beta-oxidation, response to stress; LOCATED IN: peroxisome; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ATPase, AAA-type, core (InterPro:IPR003959), Aspartate decarboxylase-like fold (InterPro:IPR009010), ATPase, AAA-type, conserved site (InterPro:IPR003960), Peroxisome biogenesis factor 1, N-terminal (InterPro:IPR015342); BEST Arabidopsis thaliana protein match is: ATPase, AAA-type, CDC48 protein (TAIR:AT3G53230.1); Has 45022 Blast hits to 26157 proteins in 3042 species: Archae - 1897; Bacteria - 15808; Metazoa - 7500; Fungi - 5597; Plants - 4311; Viruses - 29; Other Eukaryotes - 9880 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      2735911..2743065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120932.3 → NP_196464.2  peroxisome 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196464.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FNP1, Q9FQ60
      UniProtKB/TrEMBL
      A0A5S9Y2I9, A0A654FZF7
      Conserved Domains (4) summary
      cd00009
      Location:589 → 635
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      COG0464
      Location:585 → 1104
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
      pfam00004
      Location:881 → 1010
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09262
      Location:109 → 182
      PEX-1N; Peroxisome biogenesis factor 1, N-terminal

    2. NM_001343003.1 → NP_001331459.1  peroxisome 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BDY2, A0A5S9Y2I9, A0A654FZF7

    3. NM_001343004.1 → NP_001331458.1  peroxisome 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BDW7, A0A5S9Y2I9, A0A654FZF7

    4. NM_001343005.1 → NP_001331457.1  peroxisome 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BDW6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FNP1.2

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