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    AGL6 AGAMOUS-like 6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819173, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AGL6
    Official Full Name
    AGAMOUS-like 6
    Primary source
    TAIR:AT2G45650
    Locus tag
    AT2G45650
    See related
    Araport:AT2G45650
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AGAMOUS-like 6; F17K2.18; REDUCED SHOOT BRANCHING 1; RSB1
    Summary
    Sequence suggests this encodes a MADS-box transcription factor. Negatively regulates the FLC/MAF clade genes and positively regulates FT in Arabidopsis.
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    Genomic context

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    See AGL6 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Sequence:
    Chromosome: 2; NC_003071.7 (18804190..18806586)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene SIN3 associated polypeptide P18 Neighboring gene AGAMOUS-like 20 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Epistatic natural allelic variation reveals a function of AGAMOUS-LIKE6 in axillary bud formation in Arabidopsis. Huang X, et al. Plant Cell, 2012 Jun. PMID 22730404, Free PMC Article
    2. A genetic screen for leaf movement mutants identifies a potential role for AGAMOUS-LIKE 6 (AGL6) in circadian-clock control. Yoo SK, et al. Mol Cells, 2011 Mar. PMID 21331777, Free PMC Article
    3. Control of lateral organ development and flowering time by the Arabidopsis thaliana MADS-box Gene AGAMOUS-LIKE6. Koo SC, et al. Plant J, 2010 Jun 1. PMID 20230491
    4. Intronic regulatory elements determine the divergent expression patterns of AGAMOUS-LIKE6 subfamily members in Arabidopsis. Schauer SE, et al. Plant J, 2009 Sep. PMID 19473325
    5. The AGL6-ELF3-FT circuit controls flowering time in Arabidopsis. Lee K, et al. Plant Signal Behav, 2024 Dec 31. PMID 38805453, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The AGL6-ELF3-FT circuit controls flowering time in Arabidopsis.
      Title: The AGL6-ELF3-FT circuit controls flowering time in Arabidopsis.
    2. a function of AGAMOUS-LIKE6 in axillary bud formation in Arabidopsis
      Title: Epistatic natural allelic variation reveals a function of AGAMOUS-LIKE6 in axillary bud formation in Arabidopsis.
    3. agamous-like 6 plays a potential role in the regulation of the circadian clock by regulating zeitlupe mRNA level in Arabidopsis
      Title: A genetic screen for leaf movement mutants identifies a potential role for AGAMOUS-LIKE 6 (AGL6) in circadian-clock control.
    4. Results suggest that AGL6 acts as a floral promoter with a dual role, the inhibition of the transcription of the FLC/MAF genes and the promotion of FT expression in Arabidopsis.
      Title: AGAMOUS-LIKE 6 is a floral promoter that negatively regulates the FLC/MAF clade genes and positively regulates FT in Arabidopsis.
    5. Early flowering and developmental defects are caused by overexpression of AGL6.
      Title: Control of lateral organ development and flowering time by the Arabidopsis thaliana MADS-box Gene AGAMOUS-LIKE6.
    6. AGL6 and AGL13 are regulated through complex interactions of enhancer and silencer elements located in both the 5'-upstream regions and the large first introns.
      Title: Intronic regulatory elements determine the divergent expression patterns of AGAMOUS-LIKE6 subfamily members in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_130127.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within floral organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vegetative to reproductive phase transition of meristem IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    AGAMOUS-like 6
    NP_182089.1
    • AGAMOUS-like 6 (AGL6); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: vegetative to reproductive phase transition of meristem, floral organ development; LOCATED IN: nucleus; EXPRESSED IN: 8 plant structures; EXPRESSED DURING: C globular stage, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage; CONTAINS InterPro DOMAIN/s: Transcription factor, MADS-box (InterPro:IPR002100), Transcription factor, K-box (InterPro:IPR002487); BEST Arabidopsis thaliana protein match is: AGAMOUS-like 13 (TAIR:AT3G61120.1); Has 7294 Blast hits to 7293 proteins in 914 species: Archae - 0; Bacteria - 0; Metazoa - 630; Fungi - 307; Plants - 6281; Viruses - 0; Other Eukaryotes - 76 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18804190..18806586
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130127.2 → NP_182089.1  AGAMOUS-like 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_182089.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P29386
      UniProtKB/TrEMBL
      A0A5S9X7Z8, A0A654F284, A0MET6, I7EL34, I7FEX2, Q1PEU3
      Conserved Domains (2) summary
      cd00265
      Location:2 → 72
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam01486
      Location:87 → 171
      K-box; K-box region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P29386.2

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