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    AtIPCS2 Inositol phosphorylceramide synthase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818371, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AtIPCS2
    Official Full Name
    Inositol phosphorylceramide synthase 2
    Primary source
    TAIR:AT2G37940
    Locus tag
    AT2G37940
    See related
    Araport:AT2G37940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis Inositol phosphorylceramide synthase 2; enhancing RPW8-mediated HR-like cell death 1; ERH1; T8P21.15; T8P21_15
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    Genomic context

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    See AtIPCS2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    12
    Sequence:
    Chromosome: 2; NC_003071.7 (15876717..15880103)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene copper transporter 4 Neighboring gene hypothetical protein (DUF3527) Neighboring gene ncRNA Neighboring gene RING/FYVE/PHD zinc finger superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional analyses of differentially expressed isoforms of the Arabidopsis inositol phosphorylceramide synthase. Mina JG, et al. Plant Mol Biol, 2010 Jul. PMID 20309609
    2. An inositolphosphorylceramide synthase is involved in regulation of plant programmed cell death associated with defense in Arabidopsis. Wang W, et al. Plant Cell, 2008 Nov. PMID 19001565, Free PMC Article
    3. Translational Regulation of Metabolic Dynamics during Effector-Triggered Immunity. Yoo H, et al. Mol Plant, 2020 Jan 6. PMID 31568832, Free PMC Article
    4. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
    5. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Three Arabidopsis inositol phosphorylceramid (IPC) synthases were functionally analysed, to confirm them as aureobasidin A resistant AUR1p orthologues. Genes encoding these orthologues are differentially expressed in various tissue. [IPCS2]
      Title: Functional analyses of differentially expressed isoforms of the Arabidopsis inositol phosphorylceramide synthase.
    2. ERH1 encodes a plant inositolphosphorylceramide synthase, and plays an important role in modulating plant programmed cell death.
      Title: An inositolphosphorylceramide synthase is involved in regulation of plant programmed cell death associated with defense in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_129350.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables inositol phosphoceramide synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol phosphoceramide synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphotransferase activity, for other substituted phosphate groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within sphingolipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Inositol phosphorylceramide synthase 2
    NP_565875.1
    • Arabidopsis Inositol phosphorylceramide synthase 2 (AtIPCS2); BEST Arabidopsis thaliana protein match is: Arabidopsis Inositol phosphorylceramide synthase 1 (TAIR:AT3G54020.1); Has 438 Blast hits to 435 proteins in 100 species: Archae - 0; Bacteria - 0; Metazoa - 250; Fungi - 0; Plants - 103; Viruses - 0; Other Eukaryotes - 85 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      15876717..15880103
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001336682.1 → NP_001324467.1  Inositol phosphorylceramide synthase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DHT1, Q9SH93
      UniProtKB/TrEMBL
      A0A178VV03, A0A5S9X542, A0A654EZT6
      Conserved Domains (1) summary
      pfam14360
      Location:171 → 238
      PAP2_C; PAP2 superfamily C-terminal

    2. NM_129350.4 → NP_565875.1  Inositol phosphorylceramide synthase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565875.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DHT1, Q9SH93
      UniProtKB/TrEMBL
      A0A178VV03, A0A5S9X542, A0A654EZT6
      Conserved Domains (1) summary
      pfam14360
      Location:171 → 238
      PAP2_C; PAP2 superfamily C-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SH93.1

    Gene LinkOut

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