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    NETO2 neuropilin and tolloid like 2 [ Homo sapiens (human) ]

    Gene ID: 81831, updated on 3-Nov-2024

    Summary

    Official Symbol
    NETO2provided by HGNC
    Official Full Name
    neuropilin and tolloid like 2provided by HGNC
    Primary source
    HGNC:HGNC:14644
    See related
    Ensembl:ENSG00000171208 MIM:607974; AllianceGenome:HGNC:14644
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BTCL2; NEOT2
    Summary
    This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in rats encodes a protein that modulates glutamate signaling in the brain by regulating kainate receptor function. Expression of this gene may be a biomarker for proliferating infantile hemangiomas. A pseudogene of this gene is located on the long arm of chromosome 8. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
    Expression
    Broad expression in spleen (RPKM 8.8), brain (RPKM 6.7) and 17 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See NETO2 in Genome Data Viewer
    Location:
    16q12.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (47077703..47143945, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (52874528..52940774, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (47111614..47177856, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:46993862-46994528 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:46999088-46999813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7439 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7440 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10783 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10782 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7443 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7442 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7441 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:47025988-47026488 Neighboring gene DNAJA2 divergent transcript Neighboring gene DnaJ heat shock protein family (Hsp40) member A2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7444 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7445 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10784 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10785 Neighboring gene MPRA-validated peak2576 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:47112757-47113521 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7446 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7447 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7449 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7450 Neighboring gene ITFG1 antisense RNA 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:47200827-47201756 Neighboring gene ribosomal protein L23a pseudogene 72 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:47213953-47214504 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:47214505-47215056 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:47215057-47215608 Neighboring gene integrin alpha FG-GAP repeat containing 1 Neighboring gene MPRA-validated peak2577 silencer Neighboring gene proteasome 20S subunit beta 5 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10430, FLJ14724, FLJ90456

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ionotropic glutamate receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    neuropilin and tolloid-like protein 2
    Names
    brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2
    neuropilin (NRP) and tolloid (TLL)-like 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047201.2 RefSeqGene

      Range
      5000..71242
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201477.2NP_001188406.1  neuropilin and tolloid-like protein 2 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC007338, AY358718, BC108727, DA117339
      Consensus CDS
      CCDS58460.1
      UniProtKB/Swiss-Prot
      Q8NC67
      UniProtKB/TrEMBL
      Q32NC3
      Related
      ENSP00000306726.5, ENST00000303155.9
      Conserved Domains (2) summary
      cd00041
      Location:45158
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:290324
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    2. NM_018092.5NP_060562.3  neuropilin and tolloid-like protein 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_060562.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC007338, AK074937
      Consensus CDS
      CCDS10727.1
      UniProtKB/Swiss-Prot
      J3KNF1, Q7Z381, Q8NC67, Q8ND51, Q96SP4, Q9NVY8
      Related
      ENSP00000455169.1, ENST00000562435.6
      Conserved Domains (2) summary
      cd00041
      Location:45158
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:297331
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      47077703..47143945 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006721291.2XP_006721354.1  neuropilin and tolloid-like protein 2 isoform X2

      Conserved Domains (1) summary
      cd00041
      Location:45158
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    2. XM_006721289.2XP_006721352.1  neuropilin and tolloid-like protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006721352.1

      Conserved Domains (1) summary
      cd00041
      Location:45158
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    3. XM_017023740.2XP_016879229.1  neuropilin and tolloid-like protein 2 isoform X3

      UniProtKB/TrEMBL
      B7Z4I7
      Related
      ENSP00000454213.1, ENST00000562559.5
      Conserved Domains (2) summary
      cd00041
      Location:69155
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:161195
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    4. XM_047434728.1XP_047290684.1  neuropilin and tolloid-like protein 2 isoform X5

    5. XM_006721292.2XP_006721355.1  neuropilin and tolloid-like protein 2 isoform X4

      UniProtKB/TrEMBL
      Q32NC3
      Conserved Domains (1) summary
      cd00041
      Location:45158
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      52874528..52940774 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314071.1XP_054170046.1  neuropilin and tolloid-like protein 2 isoform X2

    2. XM_054314070.1XP_054170045.1  neuropilin and tolloid-like protein 2 isoform X1

    3. XM_054314072.1XP_054170047.1  neuropilin and tolloid-like protein 2 isoform X3

    4. XM_054314074.1XP_054170049.1  neuropilin and tolloid-like protein 2 isoform X5

    5. XM_054314073.1XP_054170048.1  neuropilin and tolloid-like protein 2 isoform X4