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    CNGC6 cyclic nucleotide-gated channel 6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816931, updated on 11-Apr-2024

    Summary

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    Gene symbol
    CNGC6
    Gene description
    cyclic nucleotide-gated channel 6
    Primary source
    Araport:AT2G23980
    Locus tag
    AT2G23980
    See related
    TAIR:AT2G23980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCNGC6; CYCLIC NUCLEOTIDE GATED CHANNEL 6; cyclic nucleotide-gated channel 6; T29E15.18; T29E15_18
    Summary
    Encodes a cyclic GMP-activated non-selective cation channel in the plasma membrane of guard cells.
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    Genomic context

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    See CNGC6 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Sequence:
    Chromosome: 2; NC_003071.7 (10201104..10205422, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Class I glutamine amidotransferase-like superfamily protein Neighboring gene Class I glutamine amidotransferase-like superfamily protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene early nodulin-like protein 11 Neighboring gene serine carboxypeptidase-like 22

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cyclic nucleotide-gated ion channel 6 is involved in extracellular ATP signaling and plant immunity. Duong HN, et al. Plant J, 2022 Mar. PMID 34919778, Free PMC Article
    2. Arabidopsis cyclic nucleotide-gated channel 6 is negatively modulated by multiple calmodulin isoforms during heat shock. Niu WT, et al. J Exp Bot, 2020 Jan 1. PMID 31587070
    3. Cyclic nucleotide-gated ion channel 6 mediates thermotolerance in Arabidopsis seedlings by regulating nitric oxide production via cytosolic calcium ions. Peng X, et al. BMC Plant Biol, 2019 Aug 20. PMID 31429706, Free PMC Article
    4. A heat-activated calcium-permeable channel--Arabidopsis cyclic nucleotide-gated ion channel 6--is involved in heat shock responses. Gao F, et al. Plant J, 2012 Jun. PMID 22372427
    5. Calmodulin7: recent insights into emerging roles in plant development and stress. Basu R, et al. Plant Mol Biol, 2021 Sep. PMID 34398355

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cyclic nucleotide-gated ion channel 6 is involved in extracellular ATP signaling and plant immunity.
      Title: Cyclic nucleotide-gated ion channel 6 is involved in extracellular ATP signaling and plant immunity.
    2. Three CNGC Family Members, CNGC5, CNGC6, and CNGC9, Are Required for Constitutive Growth of Arabidopsis Root Hairs as Ca(2+)-Permeable Channels.
      Title: Three CNGC Family Members, CNGC5, CNGC6, and CNGC9, Are Required for Constitutive Growth of Arabidopsis Root Hairs as Ca(2+)-Permeable Channels.
    3. Arabidopsis cyclic nucleotide-gated channel 6 is negatively modulated by multiple calmodulin isoforms during heat shock.
      Title: Arabidopsis cyclic nucleotide-gated channel 6 is negatively modulated by multiple calmodulin isoforms during heat shock.
    4. data indicate that CNGC6 acts upstream of nitric oxide in the heat shock pathway
      Title: Cyclic nucleotide-gated ion channel 6 mediates thermotolerance in Arabidopsis seedlings by regulating nitric oxide production via cytosolic calcium ions.
    5. The CNGC5 and CNGC6 genes encode unique cyclic GMP-activated nonselective Ca(2+)-permeable cation channels in the plasma membrane of Arabidopsis guard cells.
      Title: Identification of cyclic GMP-activated nonselective Ca2+-permeable cation channels and associated CNGC5 and CNGC6 genes in Arabidopsis guard cells.
    6. CNGC6 is a heat- and cAMP-activated PM Ca2+-permeable channel that is involved in heat shock responses.
      Title: A heat-activated calcium-permeable channel--Arabidopsis cyclic nucleotide-gated ion channel 6--is involved in heat shock responses.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001335878.1
    NM_001335879.1
    NM_001335880.1
    NM_001335881.1
    NM_001335882.1
    NM_001335883.1
    NM_001335884.1
    NM_001335885.1
    NM_001335886.1
    NM_127960.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables intracellularly cGMP-activated cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to heat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in root hair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclic nucleotide-gated channel 6
    NP_001318278.1
    • cyclic nucleotide-gated channel 6 (CNGC6); FUNCTIONS IN: calmodulin binding; INVOLVED IN: response to cadmium ion; LOCATED IN: plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cyclic nucleotide-binding (InterPro:IPR000595), Potassium channel, voltage-dependent, EAG/ELK/ERG (InterPro:IPR003938), Ion transport (InterPro:IPR005821), Cyclic nucleotide-binding-like (InterPro:IPR018490), RmlC-like jelly roll fold (InterPro:IPR014710), IQ calmodulin-binding region (InterPro:IPR000048); BEST Arabidopsis thaliana protein match is: cyclic nucleotide gated channel 9 (TAIR:AT4G30560.1); Has 3569 Blast hits to 3382 proteins in 249 species: Archae - 0; Bacteria - 42; Metazoa - 1579; Fungi - 32; Plants - 1028; Viruses - 0; Other Eukaryotes - 888 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      10201104..10205422 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001335878.1 → NP_001318278.1  cyclic nucleotide-gated channel 6 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82226, Q9XFS4
      UniProtKB/TrEMBL
      A0A178VQ35, A0A5S9X0Y2, A0A654EWQ3, A0A7G2EAK2
      Conserved Domains (2) summary
      PLN03192
      Location:161 → 566
      PLN03192; Voltage-dependent potassium channel; Provisional
      cd00038
      Location:514 → 645
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    2. NM_001335884.1 → NP_001323886.1  cyclic nucleotide-gated channel 6 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VQ35, A0A1P8AYC4, A0A5S9X0Y2, A0A7G2EAK2

    3. NM_001335881.1 → NP_001323885.1  cyclic nucleotide-gated channel 6 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82226, Q9XFS4
      UniProtKB/TrEMBL
      A0A178VQ35, A0A5S9X0Y2, A0A654EWQ3, A0A7G2EAK2
      Conserved Domains (2) summary
      PLN03192
      Location:161 → 566
      PLN03192; Voltage-dependent potassium channel; Provisional
      cd00038
      Location:514 → 645
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    4. NM_001335879.1 → NP_001323882.1  cyclic nucleotide-gated channel 6 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VQ35, A0A1P8AYC4, A0A5S9X0Y2, A0A7G2EAK2

    5. NM_001335886.1 → NP_001323883.1  cyclic nucleotide-gated channel 6 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82226, Q9XFS4
      UniProtKB/TrEMBL
      A0A178VQ35, A0A5S9X0Y2, A0A654EWQ3, A0A7G2EAK2
      Conserved Domains (2) summary
      PLN03192
      Location:161 → 566
      PLN03192; Voltage-dependent potassium channel; Provisional
      cd00038
      Location:514 → 645
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    6. NM_001335885.1 → NP_001323884.1  cyclic nucleotide-gated channel 6 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VQ35, A0A1P8AYC4, A0A5S9X0Y2, A0A7G2EAK2

    7. NM_001335882.1 → NP_001323879.1  cyclic nucleotide-gated channel 6 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82226, Q9XFS4
      UniProtKB/TrEMBL
      A0A178VQ35, A0A5S9X0Y2, A0A654EWQ3, A0A7G2EAK2
      Conserved Domains (2) summary
      PLN03192
      Location:161 → 566
      PLN03192; Voltage-dependent potassium channel; Provisional
      cd00038
      Location:514 → 645
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    8. NM_001335880.1 → NP_001323881.1  cyclic nucleotide-gated channel 6 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VQ35, A0A1P8AYC4, A0A5S9X0Y2, A0A7G2EAK2

    9. NM_127960.3 → NP_565560.1  cyclic nucleotide-gated channel 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565560.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82226, Q9XFS4
      UniProtKB/TrEMBL
      A0A178VQ35, A0A5S9X0Y2, A0A654EWQ3, A0A7G2EAK2
      Conserved Domains (2) summary
      PLN03192
      Location:161 → 566
      PLN03192; Voltage-dependent potassium channel; Provisional
      cd00038
      Location:514 → 645
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    10. NM_001335883.1 → NP_001323880.1  cyclic nucleotide-gated channel 6 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VQ35, A0A1P8AYI8, A0A5S9X0Y2, A0A7G2EAK2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O82226.2

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