TFPI2 tissue factor pathway inhibitor 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TFPI2provided by HGNC
Official Full Name: tissue factor pathway inhibitor 2provided by HGNC
Primary source: HGNC:HGNC:11761
See related: Ensembl:ENSG00000105825 MIM:600033; AllianceGenome:HGNC:11761
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PP5; REF1; TFPI-2
Summary: This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Expression: Biased expression in placenta (RPKM 566.0) and fat (RPKM 18.9) See more
Orthologs: mouse all
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Genomic context

Location:: 7q21.3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (93885396..93890753, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (95122034..95127402, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (93514708..93520065, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tissue factor pathway inhibitor 2: Current understanding, challenges, and future perspectives.
Title: Tissue factor pathway inhibitor 2: Current understanding, challenges, and future perspectives.
Integrative analyses of RNA-seq and ChIP-seq Reveal MITF as a Target Gene of TFPI-2 in MDA231 Cells.
Title: Integrative analyses of RNA-seq and ChIP-seq Reveal MITF as a Target Gene of TFPI-2 in MDA231 Cells.
The role of tissue factor pathway inhibitor 2 in the coagulation and fibrinolysis system.
Title: The role of tissue factor pathway inhibitor 2 in the coagulation and fibrinolysis system.
HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation.
Title: HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation.
Exosomal miR-195 in hUC-MSCs alleviates hypoxia-induced damage of trophoblast cells through tissue factor pathway inhibitor 2.
Title: Exosomal miR-195 in hUC-MSCs alleviates hypoxia-induced damage of trophoblast cells through tissue factor pathway inhibitor 2.
m(6)A RNA demethylase FTO promotes the growth, migration and invasion of pancreatic cancer cells through inhibiting TFPI-2.
Title: m(6)A RNA demethylase FTO promotes the growth, migration and invasion of pancreatic cancer cells through inhibiting TFPI-2.
MBD3 promotes hepatocellular carcinoma progression and metastasis through negative regulation of tumour suppressor TFPI2.
Title: MBD3 promotes hepatocellular carcinoma progression and metastasis through negative regulation of tumour suppressor TFPI2.
Tissue Factor Pathway Inhibitor 2: A Novel Biomarker for Predicting Asymptomatic Venous Thromboembolism in Patients with Epithelial Ovarian Cancer.
Title: Tissue Factor Pathway Inhibitor 2: A Novel Biomarker for Predicting Asymptomatic Venous Thromboembolism in Patients with Epithelial Ovarian Cancer.
MEG8 regulates Tissue Factor Pathway Inhibitor 2 (TFPI2) expression in the endothelium.
Title: MEG8 regulates Tissue Factor Pathway Inhibitor 2 (TFPI2) expression in the endothelium.
The methylation of SDC2 and TFPI2 defined three methylator phenotypes of colorectal cancer.
Title: The methylation of SDC2 and TFPI2 defined three methylator phenotypes of colorectal cancer.

Submit: New GeneRIF Correction See all GeneRIFs (125)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of tissue factor pathway inhibitor 2 (TFPI2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope transmembrane glycoprotein gp41	env	A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of tissue factor pathway inhibitor 2 (TFPI2) in peptide-treated PBMCs	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7S2782 (e-PCR)
- UniSTS:65814

TFPI2 (e-PCR)
- UniSTS:69921

D7S2733 (e-PCR)
- UniSTS:7202

RH36110 (e-PCR)
- UniSTS:9089

D7S2904 (e-PCR)
- UniSTS:68233

STS-D29992 (e-PCR)
- UniSTS:21653

RH78297 (e-PCR)
- UniSTS:1966

SHGC-34072 (e-PCR)
- UniSTS:23494

G44730 (e-PCR)
- UniSTS:95205

G49182 (e-PCR)
- UniSTS:96236

G44757 (e-PCR)
- UniSTS:95216

RH91430 (e-PCR)
- UniSTS:90867

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	TAS Traceable Author Statement more info	PubMed
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to fluid shear stress	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular matrix	TAS Traceable Author Statement more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tissue factor pathway inhibitor 2

Names: placental protein 5; retinal pigment epithelium cell factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_032914.1 RefSeqGene

Range

5239..10596

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_647

mRNA and Protein(s)

NM_001271003.2 → NP_001257932.1 tissue factor pathway inhibitor 2 isoform 2 precursor

See identical proteins and their annotated locations for NP_001257932.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.

Source sequence(s)

AC002076, AK092499, AK129833

UniProtKB/TrEMBL

A0A3B3IS67

Conserved Domains (2) summary

cd00109
Location:26 → 75

KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

pfam00014
Location:146 → 193

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
NM_001271004.2 → NP_001257933.1 tissue factor pathway inhibitor 2 isoform 3 precursor

See identical proteins and their annotated locations for NP_001257933.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AC002076, AK129833, DA831865, DA833200

UniProtKB/TrEMBL

A0A3B3IRW1

Conserved Domains (2) summary

cd00109
Location:34 → 86

KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

pfam00014
Location:95 → 149

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
NM_006528.4 → NP_006519.1 tissue factor pathway inhibitor 2 isoform 1 precursor

See identical proteins and their annotated locations for NP_006519.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC002076, AK129833

Consensus CDS

CCDS5632.1

UniProtKB/Swiss-Prot

P48307, Q66ME8, Q8NAK6, Q9UC86

UniProtKB/TrEMBL

A0A3B3IS67

Related

ENSP00000222543.5, ENST00000222543.11

Conserved Domains (2) summary

cd00109
Location:34 → 86

KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

pfam00014
Location:157 → 204

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain