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    NLRX1 NLR family member X1 [ Homo sapiens (human) ]

    Gene ID: 79671, updated on 2-Nov-2024

    Summary

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    Official Symbol
    NLRX1provided by HGNC
    Official Full Name
    NLR family member X1provided by HGNC
    Primary source
    HGNC:HGNC:29890
    See related
    Ensembl:ENSG00000160703 MIM:611947; AllianceGenome:HGNC:29890
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NOD5; NOD9; NOD26; DLNB26; CLR11.3
    Summary
    The protein encoded by this gene is a member of the NLR family and localizes to the outer mitochondrial membrane. The encoded protein is a regulator of mitochondrial antivirus responses. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2013]
    Expression
    Ubiquitous expression in esophagus (RPKM 15.5), skin (RPKM 7.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NLRX1 in Genome Data Viewer
    Location:
    11q23.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (119168334..119184016)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (119188702..119204385)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (119039043..119054725)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3970 Neighboring gene histone H4 transcription factor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5626 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3971 Neighboring gene ATP binding cassette subfamily G member 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:119027357-119027857 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:119029281-119029780 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:119039524-119040229 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:119040230-119040934 Neighboring gene NHERF family PDZ scaffold protein 4 Neighboring gene small nucleolar RNA, C/D box 150 Neighboring gene dynein regulatory complex subunit 12 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. NLRX1 attenuates apoptosis and inflammatory responses in myocardial ischemia by inhibiting MAVS-dependent NLRP3 inflammasome activation. Li H, et al. Mol Immunol, 2016 Aug. PMID 27393910
    2. NLRX1 acts as tumor suppressor by regulating TNF-α induced apoptosis and metabolism in cancer cells. Singh K, et al. Biochim Biophys Acta, 2015 May. PMID 25639646
    3. Nod-like receptor X-1 is required for rhinovirus-induced barrier dysfunction in airway epithelial cells. Unger BL, et al. J Virol, 2014 Apr. PMID 24429360, Free PMC Article
    4. Behind the Scenes: Nod-Like Receptor X1 Controls Inflammation and Metabolism. Snäkä T, et al. Front Cell Infect Microbiol, 2020. PMID 33344269, Free PMC Article
    5. Focusing on the Cell Type Specific Regulatory Actions of NLRX1. Fekete T, et al. Int J Mol Sci, 2021 Jan 28. PMID 33525671, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NLRX1 Mediates the Disruption of Intestinal Mucosal Function Caused by Porcine Astrovirus Infection via the Extracellular Regulated Protein Kinases/Myosin Light-Chain Kinase (ERK/MLCK) Pathway.
      Title: NLRX1 Mediates the Disruption of Intestinal Mucosal Function Caused by Porcine Astrovirus Infection via the Extracellular Regulated Protein Kinases/Myosin Light-Chain Kinase (ERK/MLCK) Pathway.
    2. NLRX1: a key regulator in mitochondrial respiration and colorectal cancer progression.
      Title: NLRX1: a key regulator in mitochondrial respiration and colorectal cancer progression.
    3. NLRX1: Versatile functions of a mitochondrial NLR protein that controls mitophagy.
      Title: NLRX1: Versatile functions of a mitochondrial NLR protein that controls mitophagy.
    4. NLRX1 increases human retinal pigment epithelial autophagy and reduces H2O2-induced oxidative stress and inflammation by suppressing FUNDC1 phosphorylation and NLRP3 activation.
      Title: NLRX1 increases human retinal pigment epithelial autophagy and reduces H(2)O(2)-induced oxidative stress and inflammation by suppressing FUNDC1 phosphorylation and NLRP3 activation.
    5. The regulatory role of NLRX1 in innate immunity and human disease.
      Title: The regulatory role of NLRX1 in innate immunity and human disease.
    6. NLRX1 can counteract innate immune response induced by an external stimulus favoring HBV infection by competitive inhibition of MAVS-RLRs signaling in HepG2-NTCP cells.
      Title: NLRX1 can counteract innate immune response induced by an external stimulus favoring HBV infection by competitive inhibition of MAVS-RLRs signaling in HepG2-NTCP cells.
    7. Nlrx1-Regulated Defense and Metabolic Responses to Aspergillus fumigatus Are Morphotype and Cell Type Specific.
      Title: Nlrx1-Regulated Defense and Metabolic Responses to Aspergillus fumigatus Are Morphotype and Cell Type Specific.
    8. MicroRNA-195 suppresses enterovirus A71-induced pyroptosis in human neuroblastoma cells through targeting NLRX1.
      Title: MicroRNA-195 suppresses enterovirus A71-induced pyroptosis in human neuroblastoma cells through targeting NLRX1.
    9. Focusing on the Cell Type Specific Regulatory Actions of NLRX1.
      Title: Focusing on the Cell Type Specific Regulatory Actions of NLRX1.
    10. Behind the Scenes: Nod-Like Receptor X1 Controls Inflammation and Metabolism.
      Title: Behind the Scenes: Nod-Like Receptor X1 Controls Inflammation and Metabolism.
    Submit: New GeneRIF Correction See all GeneRIFs (46)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of NLR family member X1 (NLRX1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ21478, MGC21025, MGC131937

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of RIG-I signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of interferon-beta production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of macrophage cytokine production IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrion HTP PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    NLR family member X1
    Names
    NOD-like receptor X1
    caterpiller protein 11.3
    nucleotide-binding oligomerization domain protein 26
    nucleotide-binding oligomerization domain protein 5
    nucleotide-binding oligomerization domain protein 9
    nucleotide-binding oligomerization domain, leucine rich repeat containing X1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047185.1 RefSeqGene

      Range
      5392..20683
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001282143.2 → NP_001269072.1  NLR family member X1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001269072.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 4. All three variants encode the same protein.
      Source sequence(s)
      AB094095, BX647705, DA107044
      Consensus CDS
      CCDS8416.1
      UniProtKB/Swiss-Prot
      A8K6Q1, B3KPK2, B3KTA2, Q7RTR3, Q86UT6, Q96D51, Q9H724
      UniProtKB/TrEMBL
      A0A9L9PXS9
      Related
      ENSP00000386851.1, ENST00000409991.5
      Conserved Domains (3) summary
      cd00116
      Location:698 → 885
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:698 → 726
      LRR_RI; leucine-rich repeat [structural motif]
      cl21455
      Location:161 → 320
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001282144.2 → NP_001269073.1  NLR family member X1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001269073.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AB094095, BC110890, DA107044
      Consensus CDS
      CCDS8416.1
      UniProtKB/Swiss-Prot
      A8K6Q1, B3KPK2, B3KTA2, Q7RTR3, Q86UT6, Q96D51, Q9H724
      UniProtKB/TrEMBL
      A0A9L9PXS9
      Related
      ENSP00000387334.1, ENST00000409109.6
      Conserved Domains (3) summary
      cd00116
      Location:698 → 885
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:698 → 726
      LRR_RI; leucine-rich repeat [structural motif]
      cl21455
      Location:161 → 320
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_001282358.2 → NP_001269287.1  NLR family member X1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001269287.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 4. All variants encode the same protein.
      Source sequence(s)
      AB094095, AP002956, DA441499
      Consensus CDS
      CCDS8416.1
      UniProtKB/Swiss-Prot
      A8K6Q1, B3KPK2, B3KTA2, Q7RTR3, Q86UT6, Q96D51, Q9H724
      UniProtKB/TrEMBL
      A0A9L9PXS9
      Conserved Domains (3) summary
      cd00116
      Location:698 → 885
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:698 → 726
      LRR_RI; leucine-rich repeat [structural motif]
      cl21455
      Location:161 → 320
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. NM_024618.4 → NP_078894.2  NLR family member X1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_078894.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 4. All three variants encode the same protein.
      Source sequence(s)
      AB094095, DA107044
      Consensus CDS
      CCDS8416.1
      UniProtKB/Swiss-Prot
      A8K6Q1, B3KPK2, B3KTA2, Q7RTR3, Q86UT6, Q96D51, Q9H724
      UniProtKB/TrEMBL
      A0A9L9PXS9
      Related
      ENSP00000292199.2, ENST00000292199.6
      Conserved Domains (3) summary
      cd00116
      Location:698 → 885
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:698 → 726
      LRR_RI; leucine-rich repeat [structural motif]
      cl21455
      Location:161 → 320
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    5. NM_170722.2 → NP_733840.1  NLR family member X1 isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AP002956
      Consensus CDS
      CCDS44752.1
      UniProtKB/TrEMBL
      A0A9L9PXS9

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      119168334..119184016
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011542980.2 → XP_011541282.1  NLR family member X1 isoform X1

      See identical proteins and their annotated locations for XP_011541282.1

      UniProtKB/Swiss-Prot
      A8K6Q1, B3KPK2, B3KTA2, Q7RTR3, Q86UT6, Q96D51, Q9H724
      UniProtKB/TrEMBL
      A0A9L9PXS9
      Conserved Domains (3) summary
      cd00116
      Location:698 → 885
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:698 → 726
      LRR_RI; leucine-rich repeat [structural motif]
      cl21455
      Location:161 → 320
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_006718904.2 → XP_006718967.1  NLR family member X1 isoform X2

      UniProtKB/TrEMBL
      A0A9L9PXS9
      Conserved Domains (3) summary
      cd00116
      Location:698 → 850
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:698 → 726
      LRR_AMN1; leucine-rich repeat [structural motif]
      cl21455
      Location:161 → 320
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_005271669.2 → XP_005271726.1  NLR family member X1 isoform X1

      See identical proteins and their annotated locations for XP_005271726.1

      UniProtKB/Swiss-Prot
      A8K6Q1, B3KPK2, B3KTA2, Q7RTR3, Q86UT6, Q96D51, Q9H724
      UniProtKB/TrEMBL
      A0A9L9PXS9
      Related
      ENSP00000516519.1, ENST00000706729.1
      Conserved Domains (3) summary
      cd00116
      Location:698 → 885
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:698 → 726
      LRR_RI; leucine-rich repeat [structural motif]
      cl21455
      Location:161 → 320
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. XM_047427586.1 → XP_047283542.1  NLR family member X1 isoform X2

    5. XM_047427587.1 → XP_047283543.1  NLR family member X1 isoform X2

      Related
      ENSP00000433442.1, ENST00000525863.1

    6. XM_047427589.1 → XP_047283545.1  NLR family member X1 isoform X3

      UniProtKB/TrEMBL
      A0A9L9PX86
      Related
      ENSP00000516517.1, ENST00000706728.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      119188702..119204385
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369945.1 → XP_054225920.1  NLR family member X1 isoform X1

      UniProtKB/Swiss-Prot
      A8K6Q1, B3KPK2, B3KTA2, Q7RTR3, Q86UT6, Q96D51, Q9H724

    2. XM_054369944.1 → XP_054225919.1  NLR family member X1 isoform X1

      UniProtKB/Swiss-Prot
      A8K6Q1, B3KPK2, B3KTA2, Q7RTR3, Q86UT6, Q96D51, Q9H724

    3. XM_054369946.1 → XP_054225921.1  NLR family member X1 isoform X2

    4. XM_054369947.1 → XP_054225922.1  NLR family member X1 isoform X2

    5. XM_054369948.1 → XP_054225923.1  NLR family member X1 isoform X2

    6. XM_054369949.1 → XP_054225924.1  NLR family member X1 isoform X3

      UniProtKB/TrEMBL
      A0A9L9PX86
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86UT6.1 GenPept UniProtKB/Swiss-Prot:Q86UT6

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