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    pnp5a purine nucleoside phosphorylase 5a [ Danio rerio (zebrafish) ]

    Gene ID: 791647, updated on 2-Nov-2024

    Summary

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    Official Symbol
    pnp5aprovided by ZNC
    Official Full Name
    purine nucleoside phosphorylase 5aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2553
    See related
    Ensembl:ENSDARG00000078619 AllianceGenome:ZFIN:ZDB-GENE-040426-2553
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    np; zgc:77008; wu:fd51h11
    Summary
    Predicted to enable purine-nucleoside phosphorylase activity. Predicted to act upstream of or within nucleoside metabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in purine nucleoside phosphorylase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human PNP (purine nucleoside phosphorylase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See pnp5a in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (6652967..6668424)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (6517269..6532726)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene si:ch1073-220m6.1 Neighboring gene uncharacterized LOC137496142 Neighboring gene potassium inwardly rectifying channel subfamily J member 10a Neighboring gene uncharacterized LOC137496143 Neighboring gene dual specificity phosphatase 19b Neighboring gene calpain 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Developmental exposure to Pb(2+) induces transgenerational changes to zebrafish brain transcriptome. Meyer DN, et al. Chemosphere, 2020 Apr. PMID 31816550, Free PMC Article
    2. Different expression profiles of Interleukin 11 (IL-11), Intelectin (ITLN) and Purine nucleoside phosphorylase 5a (PNP 5a) in crucian carp (Carassius auratus gibelio) in response to Cyprinid herpesvirus 2 and Aeromonas hydrophila. Podok P, et al. Fish Shellfish Immunol, 2014 May. PMID 24636855
    3. Interplay between Foxd3 and Mitf regulates cell fate plasticity in the zebrafish neural crest. Curran K, et al. Dev Biol, 2010 Aug 1. PMID 20460180, Free PMC Article
    4. Sleep deprivation impairs learning and memory by decreasing protein O-GlcNAcylation in the brain of adult zebrafish. Lee Y, et al. FASEB J, 2020 Jan. PMID 31914627
    5. pnp4a Is the Causal Gene of the Medaka Iridophore Mutant guanineless. Kimura T, et al. G3 (Bethesda), 2017 Apr 3. PMID 28258112, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC77008

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables purine-nucleoside phosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables purine-nucleoside phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nucleoside metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    purine nucleoside phosphorylase 5a
    NP_998476.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213311.2 → NP_998476.1  purine nucleoside phosphorylase 5a

      See identical proteins and their annotated locations for NP_998476.1

      Status: VALIDATED

      Source sequence(s)
      CU464117, EB919906, EB931190
      UniProtKB/TrEMBL
      A0A8M1PJ63, Q6NYG0
      Related
      ENSDARP00000093456.4, ENSDART00000102681.6
      Conserved Domains (2) summary
      COG0005
      Location:15 → 286
      XapA; Purine nucleoside phosphorylase [Nucleotide transport and metabolism]
      PRK08202
      Location:11 → 286
      PRK08202; purine nucleoside phosphorylase; Provisional

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      6652967..6668424
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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