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    Spsb3 splA/ryanodine receptor domain and SOCS box containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 79043, updated on 2-Nov-2024

    Summary

    Official Symbol
    Spsb3provided by MGI
    Official Full Name
    splA/ryanodine receptor domain and SOCS box containing 3provided by MGI
    Primary source
    MGI:MGI:1891471
    See related
    Ensembl:ENSMUSG00000024160 AllianceGenome:MGI:1891471
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SSB3; Tce1; mKIAA4204; 2310012N15Rik; 3300001M01Rik
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including negative regulation of cGAS/STING signaling pathway; negative regulation of epithelial to mesenchymal transition; and protein K48-linked ubiquitination. Predicted to be part of Cul5-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human SPSB3 (splA/ryanodine receptor domain and SOCS box containing 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 50.0), thymus adult (RPKM 39.1) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Spsb3 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.53 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25104956..25111124)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24885982..24892150)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene hydroxyacyl glutathione hydrolase Neighboring gene STARR-positive B cell enhancer ABC_E486 Neighboring gene fumarylacetoacetate hydrolase domain containing 1 Neighboring gene predicted gene, 41549 Neighboring gene STARR-seq mESC enhancer starr_42099 Neighboring gene STARR-seq mESC enhancer starr_42100 Neighboring gene insulin-like growth factor binding protein, acid labile subunit Neighboring gene STARR-positive B cell enhancer ABC_E216 Neighboring gene nucleotide binding protein 2 Neighboring gene essential meiotic structure-specific endonuclease subunit 2 Neighboring gene mitochondrial ribosomal protein S34

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Clone Names

    • KIAA4204

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of cGAS/STING signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of epithelial to mesenchymal transition ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of Cul5-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    SPRY domain-containing SOCS box protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163750.2NP_001157222.2  SPRY domain-containing SOCS box protein 3 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1), as well as variants 2, 3, 5, and 6, encodes the longest isoform (a).
      Source sequence(s)
      AC166102
      Consensus CDS
      CCDS50022.1
      UniProtKB/Swiss-Prot
      Q3U0T8, Q571F5, Q6GQX9, Q8C6A9, Q8R4S9, Q9D7E0
      Related
      ENSMUSP00000112492.2, ENSMUST00000120943.8
    2. NM_001163751.2NP_001157223.2  SPRY domain-containing SOCS box protein 3 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 5, and 6 all encode the same isoform (a).
      Source sequence(s)
      AC166102
      UniProtKB/Swiss-Prot
      Q3U0T8, Q571F5, Q6GQX9, Q8C6A9, Q8R4S9, Q9D7E0
      Related
      ENSMUSP00000112380.2, ENSMUST00000117890.8
    3. NM_001374602.1NP_001361531.1  SPRY domain-containing SOCS box protein 3 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 5, and 6 all encode the same isoform (a).
      Source sequence(s)
      AC166102
      UniProtKB/Swiss-Prot
      Q3U0T8, Q571F5, Q6GQX9, Q8C6A9, Q8R4S9, Q9D7E0
      UniProtKB/TrEMBL
      A0A9S4GQ91
      Conserved Domains (2) summary
      cd12876
      Location:104286
      SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
      cl02533
      Location:276312
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    4. NM_001400229.1NP_001387158.1  SPRY domain-containing SOCS box protein 3 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC166102
      UniProtKB/Swiss-Prot
      Q3U0T8, Q571F5, Q6GQX9, Q8C6A9, Q8R4S9, Q9D7E0
    5. NM_001400231.1NP_001387160.1  SPRY domain-containing SOCS box protein 3 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC166102
    6. NM_001400234.1NP_001387163.1  SPRY domain-containing SOCS box protein 3 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC166102
      Related
      ENSMUSP00000068567.7, ENSMUST00000068508.13
    7. NM_001400235.1NP_001387164.1  SPRY domain-containing SOCS box protein 3 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC166102
    8. NM_001400236.1NP_001387165.1  SPRY domain-containing SOCS box protein 3 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC166102
    9. NM_001400237.1NP_001387166.1  SPRY domain-containing SOCS box protein 3 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC166102
    10. NM_001400238.1NP_001387167.1  SPRY domain-containing SOCS box protein 3 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC166102
    11. NM_027141.3NP_081417.3  SPRY domain-containing SOCS box protein 3 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 5, and 6 all encode the same isoform (a).
      Source sequence(s)
      AC166102
      Consensus CDS
      CCDS28501.1
      UniProtKB/Swiss-Prot
      Q3U0T8, Q571F5, Q6GQX9, Q8C6A9, Q8R4S9, Q9D7E0
      Related
      ENSMUSP00000024976.6, ENSMUST00000024976.5

    RNA

    1. NR_182655.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC166102
      Related
      ENSMUST00000134932.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      25104956..25111124
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525170.5XP_006525233.1  SPRY domain-containing SOCS box protein 3 isoform X6

      See identical proteins and their annotated locations for XP_006525233.1

      UniProtKB/TrEMBL
      A0A9S4GQ91, D3YW96
      Related
      ENSMUSP00000112589.2, ENSMUST00000119829.8
      Conserved Domains (2) summary
      cd12876
      Location:104311
      SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
      cl02533
      Location:301337
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    2. XM_006525169.4XP_006525232.1  SPRY domain-containing SOCS box protein 3 isoform X5

      UniProtKB/TrEMBL
      A0A9S4GQ91
      Conserved Domains (2) summary
      cd12876
      Location:135342
      SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
      cl02533
      Location:332368
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    3. XM_006525165.4XP_006525228.1  SPRY domain-containing SOCS box protein 3 isoform X1

      Conserved Domains (2) summary
      cd12876
      Location:250457
      SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
      cl02533
      Location:447483
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    4. XM_006525166.5XP_006525229.1  SPRY domain-containing SOCS box protein 3 isoform X2

      Conserved Domains (1) summary
      cd12876
      Location:250414
      SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
    5. XM_011246733.3XP_011245035.1  SPRY domain-containing SOCS box protein 3 isoform X6

      See identical proteins and their annotated locations for XP_011245035.1

      UniProtKB/TrEMBL
      A0A9S4GQ91, D3YW96
      Conserved Domains (2) summary
      cd12876
      Location:104311
      SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
      cl02533
      Location:301337
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    6. XM_006525168.5XP_006525231.1  SPRY domain-containing SOCS box protein 3 isoform X4

      UniProtKB/TrEMBL
      A0A9S4GQ91
      Conserved Domains (2) summary
      cd12876
      Location:139346
      SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
      cl02533
      Location:336372
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    7. XM_030250153.1XP_030106013.1  SPRY domain-containing SOCS box protein 3 isoform X9

      Conserved Domains (2) summary
      cd12876
      Location:1183
      SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
      cl02533
      Location:173209
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...