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    IL1R2 interleukin 1 receptor type 2 [ Homo sapiens (human) ]

    Gene ID: 7850, updated on 2-Nov-2024

    Summary

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    Official Symbol
    IL1R2provided by HGNC
    Official Full Name
    interleukin 1 receptor type 2provided by HGNC
    Primary source
    HGNC:HGNC:5994
    See related
    Ensembl:ENSG00000115590 MIM:147811; AllianceGenome:HGNC:5994
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IL1RB; CD121b; IL1R2c; CDw121b; IL-1R-2; IL-1RT2; IL-1RT-2
    Summary
    The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]
    Expression
    Biased expression in appendix (RPKM 4.1), bone marrow (RPKM 3.4) and 12 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See IL1R2 in Genome Data Viewer
    Location:
    2q11.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (101991960..102028544)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (102450049..102486842)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (102608422..102645006)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11828 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16303 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16304 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 4 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:102358485-102359214 Neighboring gene Sharpr-MPRA regulatory region 8953 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:102422933-102423868 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:102424513-102425121 Neighboring gene Sharpr-MPRA regulatory region 3767 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:102509916-102510686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16305 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:102552199-102552715 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102599375-102599875 Neighboring gene long intergenic non-protein coding RNA 1127 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:102637443-102637636 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:102657879-102659078 Neighboring gene uncharacterized LOC107985926 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:102674234-102674816 Neighboring gene interleukin 1 receptor type 1 Neighboring gene Sharpr-MPRA regulatory regions 1871 and 11985 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:102775959-102776153 Neighboring gene IL1R1 antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Regulated expression and release of the IL-1 decoy receptor in human mononuclear phagocytes. Colotta F, et al. J Immunol, 1996 Apr 1. PMID 8786316
    2. Induction of intracellular interleukin-1 beta signals via type II interleukin-1 receptor in human gingival fibroblasts. Chou HH, et al. J Dent Res, 2000 Sep. PMID 11023264
    3. Association between the IL1R2 rs2072472 polymorphism and high-altitude pulmonary edema risk. Jin T, et al. Mol Genet Genomic Med, 2019 Mar. PMID 30672138, Free PMC Article
    4. The impact of genetic variants in IL1R2 on cervical cancer risk among Uygur females from China: A case-control study. Niu F, et al. Mol Genet Genomic Med, 2019 Jan. PMID 30460760, Free PMC Article
    5. Specific changes in the pancreatic expression of the interleukin 1 family of genes during experimental acute pancreatitis. Fink GW, et al. Cytokine, 1997 Dec. PMID 9417814

    See all (144) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IL1R2 promotes retinal angiogenesis to participate in retinopathy of prematurity by activating the HIF1alpha/PFKFB3 pathway.
      Title: IL1R2 promotes retinal angiogenesis to participate in retinopathy of prematurity by activating the HIF1α/PFKFB3 pathway.
    2. Il1r2 and Tnfrsf12a in transcranial magnetic stimulation effect of ischemic stroke via bioinformatics analysis.
      Title: Il1r2 and Tnfrsf12a in transcranial magnetic stimulation effect of ischemic stroke via bioinformatics analysis.
    3. Expression of interleukin-1beta and its receptor in human granulosa cells and their association with steroidogenesis.
      Title: Expression of interleukin-1β and its receptor in human granulosa cells and their association with steroidogenesis.
    4. Single-cell analysis reveals novel clonally expanded monocytes associated with IL1beta-IL1R2 pair in acute inflammatory demyelinating polyneuropathy.
      Title: Single-cell analysis reveals novel clonally expanded monocytes associated with IL1β-IL1R2 pair in acute inflammatory demyelinating polyneuropathy.
    5. Decreased Expression of EZH2 in Granulosa Cells Contributes to Endometriosis-Associated Infertility by Targeting IL-1R2.
      Title: Decreased Expression of EZH2 in Granulosa Cells Contributes to Endometriosis-Associated Infertility by Targeting IL-1R2.
    6. Over-expression of IL1R2 in PBMCs of Patients with Coronary Artery Disease and Its Clinical Significance.
      Title: Over-expression of IL1R2 in PBMCs of Patients with Coronary Artery Disease and Its Clinical Significance.
    7. Influence of Sociodemographic Characteristics and Inflammation-Related Gene Variants on the Comfort Level of Caregivers of Patients With Head and Neck Cancer.
      Title: Influence of Sociodemographic Characteristics and Inflammation-Related Gene Variants on the Comfort Level of Caregivers of Patients With Head and Neck Cancer.
    8. Cardiomyocyte IL-1R2 protects heart from ischemia/reperfusion injury by attenuating IL-17RA-mediated cardiomyocyte apoptosis.
      Title: Cardiomyocyte IL-1R2 protects heart from ischemia/reperfusion injury by attenuating IL-17RA-mediated cardiomyocyte apoptosis.
    9. Association of ITPKB, IL1R2 and COQ7 with Parkinson's disease in Taiwan.
      Title: Association of ITPKB, IL1R2 and COQ7 with Parkinson's disease in Taiwan.
    10. Induction of the IL-1RII decoy receptor by NFAT/FOXP3 blocks IL-1beta-dependent response of Th17 cells.
      Title: Induction of the IL-1RII decoy receptor by NFAT/FOXP3 blocks IL-1β-dependent response of Th17 cells.
    Submit: New GeneRIF Correction See all GeneRIFs (79)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci.
    EBI GWAS Catalog
    Genome-wide association study of sex hormones, gonadotropins and sex hormone-binding protein in Chinese men.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
    EBI GWAS Catalog
    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
    EBI GWAS Catalog
    Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-induced synapse loss requires sequential activation of CXCR4, IL-1beta receptor, and NMDA receptor PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC47725

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables interleukin-1 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-1, type II, blocking receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of cytokine production involved in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of interleukin-1 alpha production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of interleukin-1-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-1 receptor type 2
    Names
    CD121 antigen-like family member B
    IL-1 type II receptor
    IL-1R-beta
    antigen CDw121b
    interleukin-1 receptor beta
    interleukin-1 receptor type II
    type II interleukin-1 receptor, beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001261419.2 → NP_001248348.1  interleukin-1 receptor type 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001248348.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks multiple 3' exons and has an alternate 3' splice site which introduces an immediate stop codon, compared to variant 1. The encoded protein (isoform 2) has a shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AC005035, AC007165, U64094
      Consensus CDS
      CCDS58719.1
      UniProtKB/Swiss-Prot
      P27930
      Related
      ENSP00000414611.1, ENST00000441002.1
      Conserved Domains (4) summary
      cd05756
      Location:30 → 125
      Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      cd05897
      Location:136 → 230
      Ig2_IL1R2_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2)
      PHA02826
      Location:27 → 228
      PHA02826; IL-1 receptor-like protein; Provisional
      cl11960
      Location:241 → 285
      Ig; Immunoglobulin domain

    2. NM_004633.4 → NP_004624.1  interleukin-1 receptor type 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_004624.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC007165, BC039031
      Consensus CDS
      CCDS2054.1
      UniProtKB/Swiss-Prot
      D3DVJ5, P27930, Q6LCE6, Q9UE68
      Related
      ENSP00000330959.3, ENST00000332549.8
      Conserved Domains (3) summary
      cd05897
      Location:136 → 230
      Ig2_IL1R2_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2)
      pfam00047
      Location:241 → 341
      ig; Immunoglobulin domain
      cd05756
      Location:30 → 125
      Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins

    RNA

    1. NR_048564.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1, and is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC005035, AC007165, DC380050, X59770

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      101991960..102028544
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006712736.4 → XP_006712799.1  interleukin-1 receptor type 2 isoform X2

      Conserved Domains (4) summary
      cd05756
      Location:55 → 150
      Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      cd05897
      Location:161 → 255
      Ig2_IL1R2_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2)
      PHA02785
      Location:31 → 352
      PHA02785; IL-beta-binding protein; Provisional
      pfam00047
      Location:266 → 366
      ig; Immunoglobulin domain

    2. XM_006712734.4 → XP_006712797.1  interleukin-1 receptor type 2 isoform X3

      See identical proteins and their annotated locations for XP_006712797.1

      UniProtKB/Swiss-Prot
      D3DVJ5, P27930, Q6LCE6, Q9UE68
      Related
      ENSP00000377066.2, ENST00000393414.6
      Conserved Domains (3) summary
      cd05897
      Location:136 → 230
      Ig2_IL1R2_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2)
      pfam00047
      Location:241 → 341
      ig; Immunoglobulin domain
      cd05756
      Location:30 → 125
      Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins

    3. XM_011511805.4 → XP_011510107.1  interleukin-1 receptor type 2 isoform X4

      Conserved Domains (3) summary
      cd05897
      Location:116 → 210
      Ig2_IL1R2_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2)
      pfam00047
      Location:221 → 321
      ig; Immunoglobulin domain
      cl11960
      Location:53 → 105
      Ig; Immunoglobulin domain

    4. XM_011511804.4 → XP_011510106.1  interleukin-1 receptor type 2 isoform X3

      See identical proteins and their annotated locations for XP_011510106.1

      UniProtKB/Swiss-Prot
      D3DVJ5, P27930, Q6LCE6, Q9UE68
      Conserved Domains (3) summary
      cd05897
      Location:136 → 230
      Ig2_IL1R2_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2)
      pfam00047
      Location:241 → 341
      ig; Immunoglobulin domain
      cd05756
      Location:30 → 125
      Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins

    5. XM_011511801.3 → XP_011510103.1  interleukin-1 receptor type 2 isoform X1

      Conserved Domains (4) summary
      cd05756
      Location:73 → 168
      Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      cd05897
      Location:179 → 273
      Ig2_IL1R2_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2)
      PHA02785
      Location:49 → 370
      PHA02785; IL-beta-binding protein; Provisional
      pfam00047
      Location:284 → 384
      ig; Immunoglobulin domain

    6. XM_047445800.1 → XP_047301756.1  interleukin-1 receptor type 2 isoform X5

    7. XM_011511807.2 → XP_011510109.1  interleukin-1 receptor type 2 isoform X6

      UniProtKB/TrEMBL
      C9JNR0
      Related
      ENSP00000408415.1, ENST00000457817.5
      Conserved Domains (3) summary
      cd05756
      Location:73 → 168
      Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      cd05897
      Location:179 → 272
      Ig2_IL1R2_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2)
      PHA02826
      Location:70 → 271
      PHA02826; IL-1 receptor-like protein; Provisional

    8. XM_011511808.3 → XP_011510110.1  interleukin-1 receptor type 2 isoform X7

      Conserved Domains (2) summary
      smart00410
      Location:82 → 179
      IG_like; Immunoglobulin like
      pfam00047
      Location:79 → 179
      ig; Immunoglobulin domain

    RNA

    1. XR_923024.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      102450049..102486842
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343830.1 → XP_054199805.1  interleukin-1 receptor type 2 isoform X2

    2. XM_054343831.1 → XP_054199806.1  interleukin-1 receptor type 2 isoform X3

      UniProtKB/Swiss-Prot
      D3DVJ5, P27930, Q6LCE6, Q9UE68

    3. XM_054343834.1 → XP_054199809.1  interleukin-1 receptor type 2 isoform X8

    4. XM_054343832.1 → XP_054199807.1  interleukin-1 receptor type 2 isoform X4

    5. XM_054343829.1 → XP_054199804.1  interleukin-1 receptor type 2 isoform X1

    6. XM_054343833.1 → XP_054199808.1  interleukin-1 receptor type 2 isoform X5

    7. XM_054343835.1 → XP_054199810.1  interleukin-1 receptor type 2 isoform X6

    8. XM_054343836.1 → XP_054199811.1  interleukin-1 receptor type 2 isoform X7

    RNA

    1. XR_008486512.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_173343.1: Suppressed sequence

      Description
      NM_173343.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27930.1 GenPept UniProtKB/Swiss-Prot:P27930

    Gene LinkOut

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