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    srd5a1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) [ Danio rerio (zebrafish) ]

    Gene ID: 767715, updated on 2-Nov-2024

    Summary

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    Official Symbol
    srd5a1provided by ZNC
    Official Full Name
    steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060929-938
    See related
    Ensembl:ENSDARG00000020509 AllianceGenome:ZFIN:ZDB-GENE-060929-938
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:153768
    Summary
    Predicted to enable 3-oxo-5-alpha-steroid 4-dehydrogenase activity. Predicted to be involved in steroid biosynthetic process. Predicted to act upstream of or within cell differentiation; sex differentiation; and steroid metabolic process. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in prostate cancer and prostatic hypertrophy. Orthologous to human SRD5A1 (steroid 5 alpha-reductase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See srd5a1 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (27833444..27858033, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (28252682..28273956, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene adenylate cyclase 2b (brain) Neighboring gene terminal nucleotidyltransferase 4A Neighboring gene NOP2/Sun RNA methyltransferase 2 Neighboring gene ubiquitin conjugating enzyme E2 QL1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Development of a Liquid Chromatography/Mass Spectrometry-Based Inhibition Assay for the Screening of Steroid 5-α Reductase in Human and Fish Cell Lines. Kim D, et al. Molecules, 2021 Feb 8. PMID 33567691, Free PMC Article
    2. Organization of Iroquois genes in fish. Dildrop R, et al. Dev Genes Evol, 2004 Jun. PMID 15133664
    3. Estrogen defines the dorsal-ventral limit of VEGF regulation to specify the location of the hemogenic endothelial niche. Carroll KJ, et al. Dev Cell, 2014 May 27. PMID 24871948, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC153768

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in androgen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sex differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in steroid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    3-oxo-5-alpha-steroid 4-dehydrogenase 1
    NP_001070121.1
    XP_009292518.1
    XP_068071292.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076653.1 → NP_001070121.1  3-oxo-5-alpha-steroid 4-dehydrogenase 1

      See identical proteins and their annotated locations for NP_001070121.1

      Status: PROVISIONAL

      Source sequence(s)
      BC124451
      UniProtKB/TrEMBL
      Q08C19
      Related
      ENSDARP00000094674.2, ENSDART00000103898.4
      Conserved Domains (1) summary
      pfam02544
      Location:116 → 265
      Steroid_dh; 3-oxo-5-alpha-steroid 4-dehydrogenase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      27833444..27858033 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009294243.4 → XP_009292518.1  3-oxo-5-alpha-steroid 4-dehydrogenase 1 isoform X1

      See identical proteins and their annotated locations for XP_009292518.1

      UniProtKB/TrEMBL
      A0A8M3AK83, A5PMI4
      Conserved Domains (1) summary
      pfam02544
      Location:116 → 265
      Steroid_dh; 3-oxo-5-alpha-steroid 4-dehydrogenase

    2. XM_068215191.1 → XP_068071292.1  3-oxo-5-alpha-steroid 4-dehydrogenase 1 isoform X1

    RNA

    1. XR_011007454.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.