U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Slain2 SLAIN motif family, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 75991, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Slain2provided by MGI
    Official Full Name
    SLAIN motif family, member 2provided by MGI
    Primary source
    MGI:MGI:1923241
    See related
    Ensembl:ENSMUSG00000036087 AllianceGenome:MGI:1923241
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5033405K12Rik; 8030444K12Rik
    Summary
    Involved in cytoplasmic microtubule organization and regulation of microtubule polymerization. Predicted to be located in centrosome and cytosol. Predicted to colocalize with microtubule plus-end. Is expressed in several structures, including 1st branchial arch mandibular component; brain; liver lobe; and mandibular process. Orthologous to human SLAIN2 (SLAIN motif family member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 52.4), heart adult (RPKM 16.2) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Slain2 in Genome Data Viewer
    Location:
    5 C3.2; 5 38.44 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (73071705..73136184)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (72914362..72978841)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3582 Neighboring gene TXK tyrosine kinase Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:73152561-73152781 Neighboring gene tec protein tyrosine kinase Neighboring gene STARR-positive B cell enhancer ABC_E4762 Neighboring gene STARR-positive B cell enhancer ABC_E8061 Neighboring gene STARR-positive B cell enhancer ABC_E10324 Neighboring gene STARR-positive B cell enhancer ABC_E8821 Neighboring gene predicted gene, 54302 Neighboring gene predicted gene, 54289 Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 4 Neighboring gene zygote arrest 1, pseudogene

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circ-Slain2 Alleviates Cartilage Degradation and Inflammation of TMJOA.
      Title: Circ-Slain2 Alleviates Cartilage Degradation and Inflammation of TMJOA.
    2. Slain2 attenuates brain injury following subarachnoid hemorrhage by controlling axonal microtubule structure in mice.
      Title: Slain2 attenuates brain injury following subarachnoid hemorrhage by controlling axonal microtubule structure in mice.
    3. SLAIN2 is expressed throughout development and is highly enriched in brain.
      Title: Microtubule plus-end tracking proteins SLAIN1/2 and ch-TOG promote axonal development.
    4. Results identify SLAIN2 as a key component of microtubule plus end interaction networks.
      Title: SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • KIAA1458, MGC47019

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoplasmic microtubule organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule nucleation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of microtubule polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of microtubule polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    colocalizes_with microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with microtubule plus-end ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with microtubule plus-end ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    SLAIN motif-containing protein 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113423.2 → NP_001106894.1  SLAIN motif-containing protein 2 isoform b

      See identical proteins and their annotated locations for NP_001106894.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant1. It encodes isoform b, which lacks an internal segment and is shorter, compared to isoform a.
      Source sequence(s)
      AK029260, BB618957, BC076573, BY423831, BY736933
      Consensus CDS
      CCDS51517.1
      UniProtKB/Swiss-Prot
      Q05DK1, Q3UJI9, Q6ZPQ5, Q8CI08
      Related
      ENSMUSP00000116528.2, ENSMUST00000144843.8
      Conserved Domains (1) summary
      pfam15301
      Location:130 → 581
      SLAIN; SLAIN motif-containing family

    2. NM_153567.3 → NP_705795.2  SLAIN motif-containing protein 2 isoform a

      See identical proteins and their annotated locations for NP_705795.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK029260, AK039970, BB618957, BC076573, BY423831, BY736933, CF534366, CF728452, CK619668
      Consensus CDS
      CCDS19335.2
      UniProtKB/Swiss-Prot
      Q8CI08
      Related
      ENSMUSP00000115871.2, ENSMUST00000143829.5
      Conserved Domains (1) summary
      pfam15301
      Location:130 → 607
      SLAIN; SLAIN motif-containing family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      73071705..73136184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504171.3 → XP_006504234.1  SLAIN motif-containing protein 2 isoform X1

      Conserved Domains (1) summary
      pfam15301
      Location:1 → 466
      SLAIN; SLAIN motif-containing family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CI08.2 GenPept UniProtKB/Swiss-Prot:Q8CI08

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools