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    ZNF45 zinc finger protein 45 [ Homo sapiens (human) ]

    Gene ID: 7596, updated on 2-Nov-2024

    Summary

    Official Symbol
    ZNF45provided by HGNC
    Official Full Name
    zinc finger protein 45provided by HGNC
    Primary source
    HGNC:HGNC:13111
    See related
    Ensembl:ENSG00000124459 MIM:194554; AllianceGenome:HGNC:13111
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KOX5; ZNF13
    Summary
    Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Located in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 3.8), ovary (RPKM 3.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZNF45 in Genome Data Viewer
    Location:
    19q13.31
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (43912624..43935282, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46735535..46758192, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44416776..44439434, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 404 Neighboring gene uncharacterized LOC100505715 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14745 Neighboring gene ZNF45 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14746 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14747 Neighboring gene zinc finger protein 221 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10732 Neighboring gene zinc finger protein 155 Neighboring gene ZNF230 divergent transcript

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Phenotypes

    EBI GWAS Catalog

    Description
    The correlation between reading and mathematics ability at age twelve has a substantial genetic component.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 45
    Names
    BRC1744
    zinc finger protein 13
    zinc finger protein 45 (a Kruppel-associated box (KRAB) domain polypeptide)
    zinc finger protein KOX5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003425.4NP_003416.1  zinc finger protein 45

      See identical proteins and their annotated locations for NP_003416.1

      Status: VALIDATED

      Source sequence(s)
      AC006213
      Consensus CDS
      CCDS12632.1
      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
      Related
      ENSP00000269973.4, ENST00000269973.10
      Conserved Domains (6) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:190602
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:586606
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:584606
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:847
      KRAB; KRAB box
      pfam13465
      Location:319343
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      43912624..43935282 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027227.3XP_016882716.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
      Related
      ENSP00000481895.1, ENST00000615985.4
      Conserved Domains (6) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:190602
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:586606
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:584606
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:847
      KRAB; KRAB box
      pfam13465
      Location:319343
      zf-H2C2_2; Zinc-finger double domain
    2. XM_047439342.1XP_047295298.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    3. XM_017027226.3XP_016882715.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
      Conserved Domains (6) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:190602
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:586606
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:584606
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:847
      KRAB; KRAB box
      pfam13465
      Location:319343
      zf-H2C2_2; Zinc-finger double domain
    4. XM_047439333.1XP_047295289.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    5. XM_047439325.1XP_047295281.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    6. XM_011527271.2XP_011525573.1  zinc finger protein 45 isoform X1

      See identical proteins and their annotated locations for XP_011525573.1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
      Conserved Domains (6) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:190602
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:586606
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:584606
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:847
      KRAB; KRAB box
      pfam13465
      Location:319343
      zf-H2C2_2; Zinc-finger double domain
    7. XM_047439336.1XP_047295292.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    8. XM_047439332.1XP_047295288.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    9. XM_017027225.3XP_016882714.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
      Conserved Domains (6) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:190602
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:586606
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:584606
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:847
      KRAB; KRAB box
      pfam13465
      Location:319343
      zf-H2C2_2; Zinc-finger double domain
    10. XM_047439328.1XP_047295284.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    11. XM_017027220.3XP_016882709.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
      Conserved Domains (6) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:190602
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:586606
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:584606
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:847
      KRAB; KRAB box
      pfam13465
      Location:319343
      zf-H2C2_2; Zinc-finger double domain
    12. XM_047439343.1XP_047295299.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    13. XM_047439326.1XP_047295282.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    14. XM_047439338.1XP_047295294.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    15. XM_047439346.1XP_047295302.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    16. XM_047439329.1XP_047295285.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    17. XM_047439322.1XP_047295278.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    18. XM_047439345.1XP_047295301.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    19. XM_047439334.1XP_047295290.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    20. XM_047439337.1XP_047295293.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    21. XM_047439340.1XP_047295296.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    22. XM_047439330.1XP_047295286.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    23. XM_047439321.1XP_047295277.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    24. XM_047439348.1XP_047295304.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    25. XM_047439347.1XP_047295303.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    26. XM_047439323.1XP_047295279.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    27. XM_011527273.2XP_011525575.1  zinc finger protein 45 isoform X1

      See identical proteins and their annotated locations for XP_011525575.1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
      Conserved Domains (6) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:190602
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:586606
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:584606
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:847
      KRAB; KRAB box
      pfam13465
      Location:319343
      zf-H2C2_2; Zinc-finger double domain
    28. XM_011527269.2XP_011525571.1  zinc finger protein 45 isoform X1

      See identical proteins and their annotated locations for XP_011525571.1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
      Conserved Domains (6) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:190602
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:586606
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:584606
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:847
      KRAB; KRAB box
      pfam13465
      Location:319343
      zf-H2C2_2; Zinc-finger double domain
    29. XM_047439324.1XP_047295280.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    30. XM_047439320.1XP_047295276.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    31. XM_017027218.2XP_016882707.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
      Conserved Domains (6) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:190602
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:586606
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:584606
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:847
      KRAB; KRAB box
      pfam13465
      Location:319343
      zf-H2C2_2; Zinc-finger double domain
    32. XM_011527267.2XP_011525569.1  zinc finger protein 45 isoform X1

      See identical proteins and their annotated locations for XP_011525569.1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
      Conserved Domains (6) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:190602
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:586606
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:584606
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:847
      KRAB; KRAB box
      pfam13465
      Location:319343
      zf-H2C2_2; Zinc-finger double domain
    33. XM_017027222.2XP_016882711.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
      Conserved Domains (6) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:190602
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:586606
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:584606
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:847
      KRAB; KRAB box
      pfam13465
      Location:319343
      zf-H2C2_2; Zinc-finger double domain
    34. XM_047439317.1XP_047295273.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    35. XM_017027217.2XP_016882706.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
      Conserved Domains (6) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:190602
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:586606
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:584606
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:847
      KRAB; KRAB box
      pfam13465
      Location:319343
      zf-H2C2_2; Zinc-finger double domain
    36. XM_047439349.1XP_047295305.1  zinc finger protein 45 isoform X2

    37. XM_047439344.1XP_047295300.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    38. XM_047439339.1XP_047295295.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    39. XM_047439341.1XP_047295297.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    40. XM_047439319.1XP_047295275.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    41. XM_017027224.3XP_016882713.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
      Conserved Domains (6) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:190602
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:586606
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:584606
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:847
      KRAB; KRAB box
      pfam13465
      Location:319343
      zf-H2C2_2; Zinc-finger double domain
    42. XM_047439331.1XP_047295287.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    43. XM_047439335.1XP_047295291.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    44. XM_047439327.1XP_047295283.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    45. XM_047439318.1XP_047295274.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      46735535..46758192 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321979.1XP_054177954.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    2. XM_054321973.1XP_054177948.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    3. XM_054321971.1XP_054177946.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    4. XM_054321969.1XP_054177944.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    5. XM_054321964.1XP_054177939.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    6. XM_054321968.1XP_054177943.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    7. XM_054321965.1XP_054177940.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    8. XM_054321966.1XP_054177941.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    9. XM_054321963.1XP_054177938.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    10. XM_054321981.1XP_054177956.1  zinc finger protein 45 isoform X2

    11. XM_054321980.1XP_054177955.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    12. XM_054321977.1XP_054177952.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    13. XM_054321978.1XP_054177953.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    14. XM_054321970.1XP_054177945.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    15. XM_054321974.1XP_054177949.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    16. XM_054321975.1XP_054177950.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    17. XM_054321976.1XP_054177951.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    18. XM_054321972.1XP_054177947.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9
    19. XM_054321967.1XP_054177942.1  zinc finger protein 45 isoform X1

      UniProtKB/Swiss-Prot
      P17016, P78472, Q02386, Q9P1U9