CASP8 caspase 8 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: CASP8provided by VGNC
Official Full Name: caspase 8provided by VGNC
Primary source: VGNC:VGNC:119
Locus tag: CK820_G0014830
See related: Ensembl:ENSPTRG00000012801
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	13	NC_072411.2 (103265594..103320609)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	2B	NC_072400.1 (103266042..103318044)

Chromosome 13 - NC_072411.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

RH70951 (e-PCR)
- UniSTS:19740

PMC156606P1 (e-PCR)
- UniSTS:271408

D8S2278 (e-PCR)
- UniSTS:473906

PMC230316P2 (e-PCR)
- UniSTS:272180

RH104035 (e-PCR)
- UniSTS:98360

RH70497 (e-PCR)
- UniSTS:83037

D2S1853 (e-PCR)
- UniSTS:4703

G29514 (e-PCR)
- UniSTS:75140

RH15884 (e-PCR)
- UniSTS:1671

A008P44 (e-PCR)
- UniSTS:14752

RH78960 (e-PCR)
- UniSTS:4072

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: caspase-8

Names: caspase 8, apoptosis-related cysteine peptidase

XP_001172193.1

EC 3.4.22.61

XP_009442259.1

EC 3.4.22.61

XP_009442260.1

EC 3.4.22.61

XP_009442261.1

EC 3.4.22.61

XP_009442262.1

EC 3.4.22.61

XP_009442265.1

EC 3.4.22.61

XP_009442266.1

EC 3.4.22.61

XP_009442269.1

EC 3.4.22.61

XP_009442270.1

EC 3.4.22.61

XP_016805776.1

EC 3.4.22.61

XP_016805777.1

EC 3.4.22.61

XP_054535194.1

EC 3.4.22.61

XP_054535195.1

EC 3.4.22.61

XP_054535196.1

EC 3.4.22.61

XP_063647605.1

EC 3.4.22.61

XP_063647606.1

EC 3.4.22.61

XP_063647608.1

EC 3.4.22.61

XP_063647609.1

EC 3.4.22.61

XP_063647610.1

EC 3.4.22.61

XP_063647611.1

EC 3.4.22.61

XP_063647612.1

EC 3.4.22.61

XP_063647613.1

EC 3.4.22.61

XP_063647614.1

EC 3.4.22.61

XP_063647615.1

EC 3.4.22.61

XP_063647616.1

EC 3.4.22.61

XP_063647617.1

EC 3.4.22.61

XP_063647618.1

EC 3.4.22.61

XP_063647619.1

EC 3.4.22.61

XP_063647620.1

EC 3.4.22.61

XP_063647621.1

EC 3.4.22.61

XP_063647622.1

EC 3.4.22.61

XP_063647623.1

EC 3.4.22.61

XP_063647624.1

EC 3.4.22.61

XP_063647625.1

EC 3.4.22.61

XP_063647626.1

EC 3.4.22.61

XP_063647627.1

EC 3.4.22.61

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072411.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

103265594..103320609

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054679219.2 → XP_054535194.1 caspase-8 isoform X5

UniProtKB/TrEMBL

A0A2I3RN77, A0A2J8N566, A0A6D2WZ76
XM_063791539.1 → XP_063647609.1 caspase-8 isoform X5

UniProtKB/TrEMBL

A0A2I3RN77, A0A2J8N566, A0A6D2WZ76
XM_063791541.1 → XP_063647611.1 caspase-8 isoform X5

UniProtKB/TrEMBL

A0A2I3RN77, A0A2J8N566, A0A6D2WZ76
XM_063791535.1 → XP_063647605.1 caspase-8 isoform X4

UniProtKB/TrEMBL

A0A2I3T6Z1, A0A2J8N557, A0A6D2VYS4
XM_063791552.1 → XP_063647622.1 caspase-8 isoform X12
XM_063791545.1 → XP_063647615.1 caspase-8 isoform X7
XM_009443990.5 → XP_009442265.1 caspase-8 isoform X4

See identical proteins and their annotated locations for XP_009442265.1

UniProtKB/TrEMBL

A0A2I3SAR9, A0A2I3T6Z1, A0A2J8N557, A0A2J8N562, A0A6D2VYS4, A0A6D2X698

Conserved Domains (3) summary

cd00032
Location:225 → 477

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08333
Location:3 → 84

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:98 → 180

DD; Death Domain Superfamily of protein-protein interaction domains
XM_063791553.1 → XP_063647623.1 caspase-8 isoform X12
XM_063791536.1 → XP_063647606.1 caspase-8 isoform X4

UniProtKB/TrEMBL

A0A2I3T6Z1, A0A2J8N557, A0A6D2VYS4
XM_063791538.1 → XP_063647608.1 caspase-8 isoform X4

UniProtKB/TrEMBL

A0A2I3T6Z1, A0A2J8N557, A0A6D2VYS4
XM_063791543.1 → XP_063647613.1 caspase-8 isoform X5

UniProtKB/TrEMBL

A0A2I3RN77, A0A2J8N566, A0A6D2WZ76
XM_063791551.1 → XP_063647621.1 caspase-8 isoform X12
XM_001172193.5 → XP_001172193.1 caspase-8 isoform X9

See identical proteins and their annotated locations for XP_001172193.1

UniProtKB/TrEMBL

A0A2I3SAR9, A0A2J8N548, A0A2J8N562, A0A6D2WT42, A0A6D2X698, H2QJ86

Related

ENSPTRP00000021879.5

Conserved Domains (3) summary

cd00032
Location:284 → 536

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08333
Location:62 → 143

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:157 → 239

DD; Death Domain Superfamily of protein-protein interaction domains
XM_063791546.1 → XP_063647616.1 caspase-8 isoform X7
XM_009443984.5 → XP_009442259.1 caspase-8 isoform X1

UniProtKB/TrEMBL

A0A2I3SAR9, A0A2J8N562, A0A6D2X698

Conserved Domains (3) summary

cd00032
Location:269 → 521

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08333
Location:62 → 143

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:157 → 239

DD; Death Domain Superfamily of protein-protein interaction domains
XM_063791554.1 → XP_063647624.1 caspase-8 isoform X12
XM_016950288.4 → XP_016805777.1 caspase-8 isoform X6

Related

ENSPTRP00000091394.1
XM_009443994.4 → XP_009442269.1 caspase-8 isoform X4

See identical proteins and their annotated locations for XP_009442269.1

UniProtKB/TrEMBL

A0A2I3SAR9, A0A2I3T6Z1, A0A2J8N557, A0A2J8N562, A0A6D2VYS4, A0A6D2X698

Conserved Domains (3) summary

cd00032
Location:225 → 477

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08333
Location:3 → 84

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:98 → 180

DD; Death Domain Superfamily of protein-protein interaction domains
XM_063791544.1 → XP_063647614.1 caspase-8 isoform X5

UniProtKB/TrEMBL

A0A2I3RN77, A0A2J8N566, A0A6D2WZ76
XM_063791557.1 → XP_063647627.1 caspase-8 isoform X12
XM_009443986.4 → XP_009442261.1 caspase-8 isoform X4

See identical proteins and their annotated locations for XP_009442261.1

UniProtKB/TrEMBL

A0A2I3SAR9, A0A2I3T6Z1, A0A2J8N557, A0A2J8N562, A0A6D2VYS4, A0A6D2X698

Conserved Domains (3) summary

cd00032
Location:225 → 477

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08333
Location:3 → 84

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:98 → 180

DD; Death Domain Superfamily of protein-protein interaction domains
XM_063791542.1 → XP_063647612.1 caspase-8 isoform X5

UniProtKB/TrEMBL

A0A2I3RN77, A0A2J8N566, A0A6D2WZ76
XM_063791555.1 → XP_063647625.1 caspase-8 isoform X12
XM_063791550.1 → XP_063647620.1 caspase-8 isoform X10

UniProtKB/TrEMBL

A0A2I3TR27, A0A2J8N558, A0A6D2WG63
XM_009443991.5 → XP_009442266.1 caspase-8 isoform X4

See identical proteins and their annotated locations for XP_009442266.1

UniProtKB/TrEMBL

A0A2I3SAR9, A0A2I3T6Z1, A0A2J8N557, A0A2J8N562, A0A6D2VYS4, A0A6D2X698

Conserved Domains (3) summary

cd00032
Location:225 → 477

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08333
Location:3 → 84

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:98 → 180

DD; Death Domain Superfamily of protein-protein interaction domains
XM_063791548.1 → XP_063647618.1 caspase-8 isoform X8
XM_016950287.4 → XP_016805776.1 caspase-8 isoform X2

UniProtKB/TrEMBL

A0A2I3SAR9, A0A2J8N562, A0A6D2X698
XM_009443985.5 → XP_009442260.1 caspase-8 isoform X3

UniProtKB/TrEMBL

A0A2I3SAR9, A0A2J8N562, A0A6D2X698

Conserved Domains (3) summary

cd00032
Location:284 → 495

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08333
Location:62 → 143

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:157 → 239

DD; Death Domain Superfamily of protein-protein interaction domains
XM_054679220.2 → XP_054535195.1 caspase-8 isoform X5

UniProtKB/TrEMBL

A0A2I3RN77, A0A2J8N566, A0A6D2WZ76
XM_063791540.1 → XP_063647610.1 caspase-8 isoform X5

UniProtKB/TrEMBL

A0A2I3RN77, A0A2J8N566, A0A6D2WZ76
XM_063791547.1 → XP_063647617.1 caspase-8 isoform X8
XM_009443987.5 → XP_009442262.1 caspase-8 isoform X4

See identical proteins and their annotated locations for XP_009442262.1

UniProtKB/TrEMBL

A0A2I3SAR9, A0A2I3T6Z1, A0A2J8N557, A0A2J8N562, A0A6D2VYS4, A0A6D2X698

Conserved Domains (3) summary

cd00032
Location:225 → 477

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08333
Location:3 → 84

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:98 → 180

DD; Death Domain Superfamily of protein-protein interaction domains
XM_063791549.1 → XP_063647619.1 caspase-8 isoform X10

UniProtKB/TrEMBL

A0A2I3TR27, A0A2J8N558, A0A6D2WG63
XM_009443995.5 → XP_009442270.1 caspase-8 isoform X4

See identical proteins and their annotated locations for XP_009442270.1

UniProtKB/TrEMBL

A0A2I3SAR9, A0A2I3T6Z1, A0A2J8N557, A0A2J8N562, A0A6D2VYS4, A0A6D2X698

Conserved Domains (3) summary

cd00032
Location:225 → 477

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08333
Location:3 → 84

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:98 → 180

DD; Death Domain Superfamily of protein-protein interaction domains
XM_063791556.1 → XP_063647626.1 caspase-8 isoform X12
XM_054679221.2 → XP_054535196.1 caspase-8 isoform X11