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    Nuak2 NUAK family, SNF1-like kinase, 2 [ Mus musculus (house mouse) ]

    Gene ID: 74137, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Nuak2provided by MGI
    Official Full Name
    NUAK family, SNF1-like kinase, 2provided by MGI
    Primary source
    MGI:MGI:1921387
    See related
    Ensembl:ENSMUSG00000009772 AllianceGenome:MGI:1921387
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Snark; Omphk2; mKIAA0537; 1200013B22Rik
    Summary
    Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including cellular response to glucose starvation; protein phosphorylation; and regulation of hippo signaling. Is expressed in several structures, including lung; neural ectoderm; nose; paravertebral ganglion; and ventricular layer. Human ortholog(s) of this gene implicated in anencephaly. Orthologous to human NUAK2 (NUAK family kinase 2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in large intestine adult (RPKM 25.5), small intestine adult (RPKM 23.1) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nuak2 in Genome Data Viewer
    Location:
    1 E4; 1 57.24 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (132243827..132261233)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (132316125..132333488)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02247 Neighboring gene predicted gene, 38446 Neighboring gene predicted pseudogene 7241 Neighboring gene kelch domain containing 8A Neighboring gene STARR-positive B cell enhancer ABC_E2009 Neighboring gene STARR-seq mESC enhancer starr_02251 Neighboring gene predicted gene, 30744 Neighboring gene VISTA enhancer mm505 Neighboring gene RIKEN cDNA F730311O21 gene Neighboring gene STARR-positive B cell enhancer ABC_E7749 Neighboring gene STARR-positive B cell enhancer ABC_E11087 Neighboring gene transmembrane and coiled-coil domains 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Reduced sucrose nonfermenting AMPK-related kinase (SNARK) activity aggravates cancer-induced skeletal muscle wasting. Alves CRR, et al. Biomed Pharmacother, 2019 Sep. PMID 31387190, Free PMC Article
    2. Susceptibility of Snark-deficient mice to azoxymethane-induced colorectal tumorigenesis and the formation of aberrant crypt foci. Tsuchihara K, et al. Cancer Sci, 2008 Apr. PMID 18307533, Free PMC Article
    3. Sucrose nonfermenting AMPK-related kinase (SNARK) regulates exercise-stimulated and ischemia-stimulated glucose transport in the heart. Sun XL, et al. J Cell Biochem, 2019 Jan. PMID 30256437, Free PMC Article
    4. Provision of a voluntary exercise environment enhances running activity and prevents obesity in Snark-deficient mice. Ichinoseki-Sekine N, et al. Am J Physiol Endocrinol Metab, 2009 May. PMID 19276392
    5. The AMPK-related kinase SNARK regulates muscle mass and myocyte survival. Lessard SJ, et al. J Clin Invest, 2016 Feb. PMID 26690705, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPR65 promotes intestinal mucosal Th1 and Th17 cell differentiation and gut inflammation through downregulating NUAK2.
      Title: GPR65 promotes intestinal mucosal Th1 and Th17 cell differentiation and gut inflammation through downregulating NUAK2.
    2. The MicroRNA miR-696 is regulated by SNARK and reduces mitochondrial activity in mouse skeletal muscle through Pgc1alpha inhibition.
      Title: The MicroRNA miR-696 is regulated by SNARK and reduces mitochondrial activity in mouse skeletal muscle through Pgc1α inhibition.
    3. NUAK2 and RCan2 participate in the p53 mutant pro-tumorigenic network.
      Title: NUAK2 and RCan2 participate in the p53 mutant pro-tumorigenic network.
    4. These results demonstrate that SNARK is highly expressed in the heart and HL1 cardiomyocytes, and that SNARK is phosphorylated in response to ischemia and exercise and functions in the regulation of cardiac glucose transport.
      Title: Sucrose nonfermenting AMPK-related kinase (SNARK) regulates exercise-stimulated and ischemia-stimulated glucose transport in the heart.
    5. A role for SNARK in the maintenance of skeletal muscle mass under cachexia conditions.
      Title: Reduced sucrose nonfermenting AMPK-related kinase (SNARK) activity aggravates cancer-induced skeletal muscle wasting.
    6. Using liver cancer as a model, NUAK2 was identified as an essential mediator of YAP-driven hepatomegaly and tumorigenesis in vivo.
      Title: NUAK2 is a critical YAP target in liver cancer.
    7. Data (including data from studies in knockout and transgenic mice) suggest that Nuak2/Snark is involved in both adipose inflammation and energy metabolism in white/brown adipocytes; Nuak2/Snark appears to regulate thermogenesis in brown adipocytes.
      Title: Sucrose Nonfermenting-Related Kinase Regulates Both Adipose Inflammation and Energy Homeostasis in Mice and Humans.
    8. These findings reveal a critical role for SNARK in myocyte survival and the maintenance of muscle mass with age.
      Title: The AMPK-related kinase SNARK regulates muscle mass and myocyte survival.
    9. NUAK1 and NUAK2 complementarily function in the apical constriction and apico-basal elongation that associate with the dorsolateral hinge point formation in cephalic neural plate during the 5- to 10-somite stages.
      Title: Neural tube defects by NUAK1 and NUAK2 double mutation.
    10. Data show that SNARK is activated by muscle contraction and is a unique mediator of contraction-stimulated glucose transport in skeletal muscle.
      Title: Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to glucose starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to glucose starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to glucose starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of hippo signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of hippo signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NUAK family SNF1-like kinase 2
    Names
    SNF1/AMP-activated protein kinase
    omphalocele kinase 2
    NP_001181954.1
    NP_001403205.1
    NP_083054.1
    XP_006529972.1
    XP_036009854.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195025.2 → NP_001181954.1  NUAK family SNF1-like kinase 2 isoform A

      See identical proteins and their annotated locations for NP_001181954.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A) represents the longer transcript and encodes the longer isoform (A).
      Source sequence(s)
      AC160545
      Consensus CDS
      CCDS56642.1
      UniProtKB/Swiss-Prot
      Q80ZW3, Q8BZN4, Q8CIC0, Q9DBV0
      Related
      ENSMUSP00000072039.8, ENSMUST00000072177.14
      Conserved Domains (2) summary
      smart00220
      Location:57 → 315
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:53 → 315
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001416276.1 → NP_001403205.1  NUAK family SNF1-like kinase 2 isoform C

      Status: VALIDATED

      Source sequence(s)
      AC160545

    3. NM_028778.5 → NP_083054.1  NUAK family SNF1-like kinase 2 isoform B

      See identical proteins and their annotated locations for NP_083054.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (B) lacks an in-frame exon in the coding region, compared to variant A. This results in a shorter protein (isoform B), compared to isoform A.
      Source sequence(s)
      AC160545
      Consensus CDS
      CCDS15283.1
      UniProtKB/Swiss-Prot
      Q8BZN4
      Related
      ENSMUSP00000080769.6, ENSMUST00000082125.6
      Conserved Domains (2) summary
      smart00220
      Location:57 → 307
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14161
      Location:53 → 307
      STKc_NUAK2; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      132243827..132261233
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153961.1 → XP_036009854.1  NUAK family SNF1-like kinase 2 isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:1 → 208
      PKc_like; Protein Kinases, catalytic domain

    2. XM_006529909.3 → XP_006529972.1  NUAK family SNF1-like kinase 2 isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:1 → 56
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BZN4.2 GenPept UniProtKB/Swiss-Prot:Q8BZN4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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