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    PSEN1 presenilin 1 [ Pan troglodytes (chimpanzee) ]

    Gene ID: 739740, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PSEN1provided by VGNC
    Official Full Name
    presenilin 1provided by VGNC
    Primary source
    VGNC:VGNC:3326
    Locus tag
    CK820_G0002833
    See related
    Ensembl:ENSPTRG00000006510
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 15
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 15 NC_072413.2 (71113122..71194274)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 14 NC_072412.1 (64408611..64489756)

    Chromosome 15 - NC_072413.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104002098 Neighboring gene required for meiotic nuclear division protein 1 homolog Neighboring gene RNA binding motif protein 25 Neighboring gene uncharacterized LOC134808373 Neighboring gene U6 spliceosomal RNA Neighboring gene papilin, proteoglycan like sulfated glycoprotein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables aspartic endopeptidase activity, intramembrane cleaving IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables beta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cadherin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amyloid precursor protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in smooth endoplasmic reticulum calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Presenilin-1; presenilin-1
    Names
    presenilin 1 (Alzheimer disease 3)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072413.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      71113122..71194274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_016926347.4 → XP_016781836.1  presenilin-1 isoform X3

      UniProtKB/TrEMBL
      A0A2I3RBB3, A0A2J8PJA0, A0A2J8PJB9, A0A6D2XJV1, A0A803KLE9, K7CVQ1
      Conserved Domains (1) summary
      pfam01080
      Location:72 → 453
      Presenilin

    2. XM_016926341.4 → XP_016781830.1  presenilin-1 isoform X2

      UniProtKB/TrEMBL
      A0A2I3RBB3, A0A2J8PJB3, A0A2J8PJB9, A0A6D2X6D4, A0A6D2XJV1, H2Q8K1
      Related
      ENSPTRP00000061908.1
      Conserved Domains (1) summary
      pfam01080
      Location:76 → 457
      Presenilin

    3. XM_016926336.3 → XP_016781825.1  presenilin-1 isoform X1

    4. XM_063793652.1 → XP_063649722.1  presenilin-1 isoform X2

      UniProtKB/TrEMBL
      A0A2I3RBB3, A0A2J8PJB3, A0A2J8PJB9, A0A6D2X6D4, A0A6D2XJV1, H2Q8K1

    5. XM_063793653.1 → XP_063649723.1  presenilin-1 isoform X3

      UniProtKB/TrEMBL
      A0A2I3RBB3, A0A2J8PJA0, A0A2J8PJB9, A0A6D2XJV1, A0A803KLE9, K7CVQ1

    6. XM_016926343.4 → XP_016781832.1  presenilin-1 isoform X3

      UniProtKB/TrEMBL
      A0A2I3RBB3, A0A2J8PJA0, A0A2J8PJB9, A0A6D2XJV1, A0A803KLE9, K7CVQ1
      Conserved Domains (1) summary
      pfam01080
      Location:72 → 453
      Presenilin

    7. XM_016926338.3 → XP_016781827.1  presenilin-1 isoform X2

      UniProtKB/TrEMBL
      A0A2I3RBB3, A0A2J8PJB3, A0A2J8PJB9, A0A6D2X6D4, A0A6D2XJV1, H2Q8K1
      Conserved Domains (1) summary
      pfam01080
      Location:76 → 457
      Presenilin

    8. XM_016926344.4 → XP_016781833.1  presenilin-1 isoform X3

      UniProtKB/TrEMBL
      A0A2I3RBB3, A0A2J8PJA0, A0A2J8PJB9, A0A6D2XJV1, A0A803KLE9, K7CVQ1
      Conserved Domains (1) summary
      pfam01080
      Location:72 → 453
      Presenilin

    9. XM_016926340.4 → XP_016781829.1  presenilin-1 isoform X2

      UniProtKB/TrEMBL
      A0A2I3RBB3, A0A2J8PJB3, A0A2J8PJB9, A0A6D2X6D4, A0A6D2XJV1, H2Q8K1
      Related
      ENSPTRP00000011045.4
      Conserved Domains (1) summary
      pfam01080
      Location:76 → 457
      Presenilin

    10. XM_016926339.4 → XP_016781828.1  presenilin-1 isoform X2

      UniProtKB/TrEMBL
      A0A2I3RBB3, A0A2J8PJB3, A0A2J8PJB9, A0A6D2X6D4, A0A6D2XJV1, H2Q8K1
      Conserved Domains (1) summary
      pfam01080
      Location:76 → 457
      Presenilin

    11. XM_016926346.4 → XP_016781835.1  presenilin-1 isoform X3

      UniProtKB/TrEMBL
      A0A2I3RBB3, A0A2J8PJA0, A0A2J8PJB9, A0A6D2XJV1, A0A803KLE9, K7CVQ1
      Conserved Domains (1) summary
      pfam01080
      Location:72 → 453
      Presenilin

    12. XM_063793655.1 → XP_063649725.1  presenilin-1 isoform X4

      UniProtKB/TrEMBL
      A0A2I3TCR8, A0A2J8PJA6, A0A6D2XVI8

    13. XM_016926348.4 → XP_016781837.1  presenilin-1 isoform X4

      UniProtKB/TrEMBL
      A0A2I3TCR8, A0A2J8PJA6, A0A6D2XVI8
      Related
      ENSPTRP00000087035.1
      Conserved Domains (1) summary
      pfam01080
      Location:1 → 374
      Presenilin
    Nucleotide Protein
    Heading Accession and Version

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