IRF2BPL interferon regulatory factor 2 binding protein like [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Gene symbol: IRF2BPL
Gene description: interferon regulatory factor 2 binding protein like
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as: EAP1; C14orf4L
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	7	NC_041760.1 (139132189..139136156, complement)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	7	NC_027899.1 (139451714..139455681, complement)

Chromosome 7 - NC_041760.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EAP1 may control reproductive cyclicity by inhibiting downstream repressor genes involved in the neuroendocrine control of reproductive function.
Title: Hypothalamic EAP1 (enhanced at puberty 1) is required for menstrual cyclicity in nonhuman primates.
common genetic variation in the EAP1 locus increases the susceptibility to loss/disruption of menstrual cyclicity
Title: A single-nucleotide polymorphism in the EAP1 gene is associated with amenorrhea/oligomenorrhea in nonhuman primates.
EAP1 is a transcriptional regulator that, acting within the neuroendocrine brain, contributes to controlling female reproductive function
Title: Enhanced at puberty 1 (EAP1) is a new transcriptional regulator of the female neuroendocrine reproductive axis.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: probable E3 ubiquitin-protein ligase IRF2BPL

Names: Enhanced at puberty protein 1; chromosome 14 open reading frame 4-like; enhanced at puberty 1; polyglutamine-containing

NP_001040589.2

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001047124.3 → NP_001040589.2 probable E3 ubiquitin-protein ligase IRF2BPL

Status: VALIDATED

Source sequence(s)

QNVO02000421

UniProtKB/Swiss-Prot

Q2MJS2

Conserved Domains (2) summary

cd16511
Location:711 → 766

vRING-HC_IRF2BP1_like; variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein IRF-2BP1, IRF-2BP2, and similar proteins

pfam11261
Location:10 → 61

IRF-2BP1_2; Interferon regulatory factor 2-binding protein zinc finger