Dazl deleted in azoospermia-like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dazlprovided by RGD
Official Full Name: deleted in azoospermia-likeprovided by RGD
Primary source: RGD:1591714
See related: EnsemblRapid:ENSRNOG00000023474 AllianceGenome:RGD:1591714
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity; mRNA 3'-UTR binding activity; and translation activator activity. Predicted to be involved in 3'-UTR-mediated mRNA stabilization and positive regulation of translational initiation. Predicted to act upstream of or within female meiosis II; oocyte maturation; and positive regulation of meiotic nuclear division. Predicted to be located in nucleus and ribosome. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Orthologous to several human genes including DAZL (deleted in azoospermia like). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Restricted expression toward (RPKM 170.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 9q12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (18193363..18210100)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (10695593..10712330)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (12633983..12651017)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Detailed histological analysis of DAZL-deficient rat testes revealed an apparently intact spermatogonial stem cell compartment, but clear failure to produce mature haploid gametes resulting in infertility
Title: Sterile testis complementation with spermatogonial lines restores fertility to DAZL-deficient rats and maximizes donor germline transmission.

Submit: New GeneRIF Correction

General gene information

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Markers

Dazl (e-PCR), detects polymorphism
- UniSTS:234033

G65760 (e-PCR)
- UniSTS:225895

Dazl (e-PCR), detects polymorphism
- UniSTS:479093

Dazl (e-PCR), detects polymorphism
- UniSTS:548036

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables translation activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA stabilization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within female meiosis II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within germ cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within oocyte maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of meiotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of translational initiation	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in ribosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: deleted in azoospermia-like

Names: deleted in azoospermia protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.