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    Tmem59l transmembrane protein 59-like [ Mus musculus (house mouse) ]

    Gene ID: 67937, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Tmem59lprovided by MGI
    Official Full Name
    transmembrane protein 59-likeprovided by MGI
    Primary source
    MGI:MGI:1915187
    See related
    Ensembl:ENSMUSG00000035964 AllianceGenome:MGI:1915187
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5330410G16Rik
    Summary
    Involved in branching involved in ureteric bud morphogenesis. Predicted to be located in Golgi membrane. Is expressed in several structures, including genitourinary system; liver; lung; nervous system; and retina. Orthologous to human TMEM59L (transmembrane protein 59 like). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 122.7), cortex adult (RPKM 82.2) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem59l in Genome Data Viewer
    Location:
    8 B3.3; 8 34.15 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70936505..70939998, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70483855..70487348, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CREB regulated transcription coactivator 1 Neighboring gene kelch-like 26 Neighboring gene STARR-positive B cell enhancer ABC_E1368 Neighboring gene RIKEN cDNA 1700020G03 gene Neighboring gene cytokine receptor-like factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mutational analysis of genes with ureteric progenitor cell-specific expression in branching morphogenesis of the mouse kidney. Rutledge EA, et al. Dev Dyn, 2020 Jun. PMID 32017326, Free PMC Article
    2. Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development. Rutledge EA, et al. Development, 2017 Sep 1. PMID 28705898, Free PMC Article
    3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in branching involved in ureteric bud morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 59-like
    Names
    brain-specific membrane-anchored protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368366.1 → NP_001355295.1  transmembrane protein 59-like isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC157774

    2. NM_001368367.1 → NP_001355296.1  transmembrane protein 59-like isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC157774

    3. NM_182991.3 → NP_892036.1  transmembrane protein 59-like isoform 1 precursor

      See identical proteins and their annotated locations for NP_892036.1

      Status: VALIDATED

      Source sequence(s)
      AC157774
      Consensus CDS
      CCDS22368.1
      UniProtKB/Swiss-Prot
      Q7TNI2
      Related
      ENSMUSP00000043659.8, ENSMUST00000045286.9
      Conserved Domains (1) summary
      pfam12280
      Location:72 → 278
      BSMAP; Brain specific membrane anchored protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      70936505..70939998 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TNI2.1 GenPept UniProtKB/Swiss-Prot:Q7TNI2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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