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    Tmem33 transmembrane protein 33 [ Mus musculus (house mouse) ]

    Gene ID: 67878, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Tmem33provided by MGI
    Official Full Name
    transmembrane protein 33provided by MGI
    Primary source
    MGI:MGI:1915128
    See related
    Ensembl:ENSMUSG00000037720 AllianceGenome:MGI:1915128
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    db83; 1110006G02Rik; 1600019D15Rik; 2410089A21Rik; 2700052H22Rik; 5430406L04Rik
    Summary
    Predicted to be involved in several processes, including endoplasmic reticulum tubular network organization; positive regulation of endoplasmic reticulum unfolded protein response; and regulation of endoplasmic reticulum tubular network organization. Predicted to be located in endoplasmic reticulum membrane; melanosome; and nuclear envelope. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including central nervous system; nasal cavity epithelium; retina; submandibular gland primordium; and trigeminal nerve. Orthologous to human TMEM33 (transmembrane protein 33). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 12.1), whole brain E14.5 (RPKM 11.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem33 in Genome Data Viewer
    Location:
    5 C3.1; 5 36.0 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (67417908..67448804)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (67260565..67291461)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr5:67623014-67623314 Neighboring gene predicted gene, 33293 Neighboring gene predicted gene, 40314 Neighboring gene STARR-positive B cell enhancer ABC_E3579 Neighboring gene STARR-seq mESC enhancer starr_13313 Neighboring gene CRISPRi-validated cis-regulatory element for Bend4 and Slc30a9 Neighboring gene solute carrier family 30 (zinc transporter), member 9 Neighboring gene STARR-seq mESC enhancer starr_13315 Neighboring gene STARR-seq mESC enhancer starr_13316 Neighboring gene BEN domain containing 4 Neighboring gene predicted gene, 33345

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. miR-29a-5p rescues depressive-like behaviors in a CUMS-induced mouse model by facilitating microglia M2-polarization in the prefrontal cortex via TMEM33 suppression. Yang JC, et al. J Affect Disord, 2024 Sep 1. PMID 38821373
    2. TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells. Arhatte M, et al. Nat Commun, 2019 May 2. PMID 31048699, Free PMC Article
    3. PKM2-TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability. Liu F, et al. EMBO J, 2021 Nov 15. PMID 34487377, Free PMC Article
    4. Deletion in the N-terminal half of olfactomedin 1 modifies its interaction with synaptic proteins and causes brain dystrophy and abnormal behavior in mice. Nakaya N, et al. Exp Neurol, 2013 Dec. PMID 24095980, Free PMC Article
    5. Elucidation of the 14-3-3ζ interactome reveals critical roles of RNA-splicing factors during adipogenesis. Mugabo Y, et al. J Biol Chem, 2018 May 4. PMID 29530978, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-29a-5p rescues depressive-like behaviors in a CUMS-induced mouse model by facilitating microglia M2-polarization in the prefrontal cortex via TMEM33 suppression.
      Title: miR-29a-5p rescues depressive-like behaviors in a CUMS-induced mouse model by facilitating microglia M2-polarization in the prefrontal cortex via TMEM33 suppression.
    2. Study shows that TMEM33 interacts with the ion channel polycystin-2 at the endoplasmic reticulum (ER) membrane, enhancing its opening over the whole physiological calcium range in ER liposomes fused to planar bilayers. Results identify a key role for TMEM33 in the regulation of intracellular calcium homeostasis of renal proximal convoluted tubule cells and establish a causal link between TMEM33 and acute kidney injury.
      Title: TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in endoplasmic reticulum tubular network organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of IRE1-mediated unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of IRE1-mediated unfolded protein response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of PERK-mediated unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of PERK-mediated unfolded protein response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of endoplasmic reticulum tubular network organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of endoplasmic reticulum tubular network organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in melanosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 33

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285452.1 → NP_001272381.1  transmembrane protein 33 isoform 1

      See identical proteins and their annotated locations for NP_001272381.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AC102896, AK005493, AK012413, AK139978, AK165369, CJ103460
      Consensus CDS
      CCDS19317.1
      UniProtKB/Swiss-Prot
      Q544Q3, Q9CR67, Q9D3M3, Q9DAV4
      Related
      ENSMUSP00000124390.2, ENSMUST00000161369.3
      Conserved Domains (1) summary
      pfam03661
      Location:9 → 245
      UPF0121; Uncharacterized protein family (UPF0121)

    2. NM_028975.4 → NP_083251.2  transmembrane protein 33 isoform 1

      See identical proteins and their annotated locations for NP_083251.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AC102896, AK012413, AK017281, AK139978, AK165369
      Consensus CDS
      CCDS19317.1
      UniProtKB/Swiss-Prot
      Q544Q3, Q9CR67, Q9D3M3, Q9DAV4
      Related
      ENSMUSP00000042852.6, ENSMUST00000037918.12
      Conserved Domains (1) summary
      pfam03661
      Location:9 → 245
      UPF0121; Uncharacterized protein family (UPF0121)

    3. NM_030108.2 → NP_084384.1  transmembrane protein 33 isoform 2

      See identical proteins and their annotated locations for NP_084384.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, the 3' coding region and the 3' UTR, compared to variant 3. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC102896, AK012413, AK017281, AK139978
      Consensus CDS
      CCDS51511.1
      UniProtKB/TrEMBL
      A0A0R4J1Z3
      Related
      ENSMUSP00000124766.2, ENSMUST00000160352.8
      Conserved Domains (1) summary
      pfam03661
      Location:9 → 245
      UPF0121; Uncharacterized protein family (UPF0121)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      67417908..67448804
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CR67.1 GenPept UniProtKB/Swiss-Prot:Q9CR67

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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