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    Iah1 isoamyl acetate-hydrolyzing esterase 1 homolog [ Mus musculus (house mouse) ]

    Gene ID: 67732, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Iah1provided by MGI
    Official Full Name
    isoamyl acetate-hydrolyzing esterase 1 homologprovided by MGI
    Primary source
    MGI:MGI:1914982
    See related
    Ensembl:ENSMUSG00000062054 AllianceGenome:MGI:1914982
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1500019E20Rik; 4833421E05Rik
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in lipid catabolic process. Is expressed in central nervous system; genitourinary system; gut gland; and thymus primordium. Orthologous to human IAH1 (isoamyl acetate hydrolyzing esterase 1 (putative)). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in kidney adult (RPKM 89.1), genital fat pad adult (RPKM 63.2) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Iah1 in Genome Data Viewer
    Location:
    12 A1.3; 12 8.3 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (21366363..21373608)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (21316362..21323607)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 Neighboring gene integrin beta 1 binding protein 1 Neighboring gene predicted gene, 25821 Neighboring gene cleavage and polyadenylation specificity factor 3 Neighboring gene STARR-positive B cell enhancer ABC_E1152 Neighboring gene a disintegrin and metallopeptidase domain 17 Neighboring gene predicted gene, 22766 Neighboring gene RIKEN cDNA F630048H11 gene Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ablation of Iah1, a candidate gene for diet-induced fatty liver, does not affect liver lipid accumulation in mice. Masuya T, et al. PLoS One, 2020. PMID 32407372, Free PMC Article
    2. Detection of differentially expressed candidate genes for a fatty liver QTL on mouse chromosome 12. Kobayashi M, et al. BMC Genet, 2016 Jun 6. PMID 27266874, Free PMC Article
    3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Iah1 deficiency did not cause liver lipid accumulation
      Title: Ablation of Iah1, a candidate gene for diet-induced fatty liver, does not affect liver lipid accumulation in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    isoamyl acetate-hydrolyzing esterase 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026347.3 → NP_080623.2  isoamyl acetate-hydrolyzing esterase 1 homolog

      See identical proteins and their annotated locations for NP_080623.2

      Status: VALIDATED

      Source sequence(s)
      AI837665, AK005287, AK011299
      Consensus CDS
      CCDS25835.1
      UniProtKB/Swiss-Prot
      Q9DB29
      Related
      ENSMUSP00000076090.7, ENSMUST00000076813.8
      Conserved Domains (1) summary
      cd01838
      Location:17 → 210
      Isoamyl_acetate_hydrolase_like; Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      21366363..21373608
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515175.3 → XP_006515238.1  isoamyl acetate-hydrolyzing esterase 1 homolog isoform X1

      Conserved Domains (1) summary
      cd01838
      Location:17 → 211
      Isoamyl_acetate_hydrolase_like; Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of ...

    2. XM_006515178.4 → XP_006515241.1  isoamyl acetate-hydrolyzing esterase 1 homolog isoform X4

      UniProtKB/TrEMBL
      A0A1Y7VLY5
      Related
      ENSMUSP00000152779.2, ENSMUST00000222344.2
      Conserved Domains (1) summary
      cd01838
      Location:17 → 149
      Isoamyl_acetate_hydrolase_like; Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of ...

    3. XM_006515176.4 → XP_006515239.1  isoamyl acetate-hydrolyzing esterase 1 homolog isoform X2

      Conserved Domains (1) summary
      cd01838
      Location:17 → 153
      Isoamyl_acetate_hydrolase_like; Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of ...

    4. XM_006515177.3 → XP_006515240.1  isoamyl acetate-hydrolyzing esterase 1 homolog isoform X3

      Conserved Domains (1) summary
      cd01838
      Location:3 → 135
      Isoamyl_acetate_hydrolase_like; Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DB29.1 GenPept UniProtKB/Swiss-Prot:Q9DB29

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