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    Spaca1 sperm acrosome associated 1 [ Mus musculus (house mouse) ]

    Gene ID: 67652, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Spaca1provided by MGI
    Official Full Name
    sperm acrosome associated 1provided by MGI
    Primary source
    MGI:MGI:1914902
    See related
    Ensembl:ENSMUSG00000028264 AllianceGenome:MGI:1914902
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700124L11Rik; 4930540L03Rik
    Summary
    Acts upstream of or within acrosome assembly. Located in acrosomal membrane. Human ortholog(s) of this gene implicated in spermatogenic failure 85. Orthologous to human SPACA1 (sperm acrosome associated 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 74.4) See more
    Orthologs
    human all
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    Genomic context

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    See Spaca1 in Genome Data Viewer
    Location:
    4 A5; 4 16.63 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (34024872..34050067, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (34024872..34050067, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33105 Neighboring gene cannabinoid receptor 1 Neighboring gene predicted gene, 25623 Neighboring gene predicted gene, 46855

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cleavage of SPACA1 regulates assembly of sperm-egg membrane fusion machinery in mature spermatozoa†. Yamatoya K, et al. Biol Reprod, 2020 Mar 13. PMID 31836887
    2. SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia. Fujihara Y, et al. Development, 2012 Oct. PMID 22949614
    3. Human Globozoospermia-Related Gene Spata16 Is Required for Sperm Formation Revealed by CRISPR/Cas9-Mediated Mouse Models. Fujihara Y, et al. Int J Mol Sci, 2017 Oct 21. PMID 29065458, Free PMC Article
    4. Disruption in CYLC1 leads to acrosome detachment, sperm head deformity, and male in/subfertility in humans and mice. Jin HJ, et al. Elife, 2024 Apr 4. PMID 38573307, Free PMC Article
    5. Transgenerational epigenetic effects imposed by neonicotinoid thiacloprid exposure. Dali O, et al. Life Sci Alliance, 2024 Feb. PMID 37973188, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cleavage of SPACA1 regulates assembly of sperm-egg membrane fusion machinery in mature spermatozoadagger.
      Title: Cleavage of SPACA1 regulates assembly of sperm-egg membrane fusion machinery in mature spermatozoa†.
    2. SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia.
      Title: SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acrosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within acrosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in acrosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in acrosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in inner acrosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sperm acrosome membrane-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290443.1 → NP_001277372.1  sperm acrosome membrane-associated protein 1 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' terminal exon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK007270, BY450124, BY706285
      Consensus CDS
      CCDS71357.1
      UniProtKB/TrEMBL
      B1AWF1
      Related
      ENSMUSP00000081785.5, ENSMUST00000084734.11
      Conserved Domains (1) summary
      cd13783
      Location:30 → 278
      SPACA1; Sperm acrosome membrane-associated protein 1

    2. NM_026293.3 → NP_080569.1  sperm acrosome membrane-associated protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_080569.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL732568
      Consensus CDS
      CCDS18026.1
      UniProtKB/Swiss-Prot
      Q9DA48
      UniProtKB/TrEMBL
      B1AWF2
      Related
      ENSMUSP00000029927.6, ENSMUST00000029927.6
      Conserved Domains (1) summary
      cd13783
      Location:30 → 285
      SPACA1; Sperm acrosome membrane-associated protein 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      34024872..34050067 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DA48.1 GenPept UniProtKB/Swiss-Prot:Q9DA48

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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