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    Srfbp1 serum response factor binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 67222, updated on 18-Sep-2024

    Summary

    Official Symbol
    Srfbp1provided by MGI
    Official Full Name
    serum response factor binding protein 1provided by MGI
    Primary source
    MGI:MGI:1914472
    See related
    Ensembl:ENSMUSG00000024528 AllianceGenome:MGI:1914472
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p49/STRAP; 2810036K01Rik
    Summary
    Predicted to be involved in maturation of SSU-rRNA. Located in nucleus. Is expressed in several structures, including axial musculature; genitourinary system; neural ectoderm; orbito-sphenoid; and submandibular gland primordium. Orthologous to human SRFBP1 (serum response factor binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 7.6), placenta adult (RPKM 5.3) and 21 other tissues See more
    Orthologs
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    Genomic context

    See Srfbp1 in Genome Data Viewer
    Location:
    18 D1; 18 28.21 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (52598703..52625005)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (52465631..52491933)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44599 Neighboring gene predicted gene, 22259 Neighboring gene STARR-seq mESC enhancer starr_44600 Neighboring gene ferritin mitochondrial Neighboring gene STARR-seq mESC enhancer starr_44601 Neighboring gene STARR-positive B cell enhancer ABC_E7585 Neighboring gene STARR-seq mESC enhancer starr_44602 Neighboring gene ribosomal protein S3A pseudogene Neighboring gene lysyl oxidase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of 90S preribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serum response factor-binding protein 1
    Names
    SRF-dependent transcription regulation associated protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026040.4NP_080316.3  serum response factor-binding protein 1

      See identical proteins and their annotated locations for NP_080316.3

      Status: VALIDATED

      Source sequence(s)
      AC109203
      Consensus CDS
      CCDS37819.1
      UniProtKB/Swiss-Prot
      Q3UGY0, Q3UMK2, Q3UR20, Q8R3W6, Q9CRL0, Q9CZ91
      Related
      ENSMUSP00000025406.8, ENSMUST00000025406.9
      Conserved Domains (1) summary
      pfam09073
      Location:411440
      BUD22; BUD22

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      52598703..52625005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_386008.4 RNA Sequence