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    Blzf1 basic leucine zipper nuclear factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 66352, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Blzf1provided by MGI
    Official Full Name
    basic leucine zipper nuclear factor 1provided by MGI
    Primary source
    MGI:MGI:1201607
    See related
    Ensembl:ENSMUSG00000026577 AllianceGenome:MGI:1201607
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Jem-1; Blzf1l; Golgin-45; 1700030G05Rik
    Summary
    Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in Golgi organization and Golgi to plasma membrane protein transport. Located in Golgi apparatus. Orthologous to human BLZF1 (basic leucine zipper nuclear factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 5.4), bladder adult (RPKM 4.5) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Blzf1 in Genome Data Viewer
    Location:
    1 H2.2; 1 71.6 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (164117368..164135056, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (164289799..164307487, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02865 Neighboring gene STARR-seq mESC enhancer starr_02866 Neighboring gene solute carrier family 19 (thiamine transporter), member 2 Neighboring gene STARR-seq mESC enhancer starr_02867 Neighboring gene coiled-coil domain containing 181 Neighboring gene STARR-positive B cell enhancer ABC_E797 Neighboring gene NME/NM23 family member 7 Neighboring gene STARR-positive B cell enhancer ABC_E5840 Neighboring gene STARR-seq mESC enhancer starr_02870 Neighboring gene predicted gene, 39690 Neighboring gene ATPase, Na+/K+ transporting, beta 1 polypeptide

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. JEM-1, a novel gene encoding a leucine-zipper nuclear factor upregulated during retinoid-induced maturation of NB4 promyelocytic leukaemia. Duprez E, et al. Oncogene, 1997 Apr 3. PMID 9129147
    2. A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic. Short B, et al. J Cell Biol, 2001 Dec 10. PMID 11739401, Free PMC Article
    3. Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. Pilot-Storck F, et al. Mol Cell Proteomics, 2010 Jul. PMID 20368287, Free PMC Article
    4. Network organization of the huntingtin proteomic interactome in mammalian brain. Shirasaki DI, et al. Neuron, 2012 Jul 12. PMID 22794259, Free PMC Article
    5. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi to plasma membrane protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Golgi to plasma membrane protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    golgin-45

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160208.1 → NP_001153680.1  golgin-45 isoform b

      See identical proteins and their annotated locations for NP_001153680.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode isoform b.
      Source sequence(s)
      AC105161, AK006544, AK029787
      Consensus CDS
      CCDS48423.1
      UniProtKB/Swiss-Prot
      Q3TJC4, Q8C0U6, Q8R2X8, Q9DAV7
      UniProtKB/TrEMBL
      Q3TBM0, Q3V485
      Related
      ENSMUSP00000083196.4, ENSMUST00000086032.4
      Conserved Domains (1) summary
      pfam08227
      Location:184 → 229
      DASH_Hsk3; DASH complex subunit Hsk3 like

    2. NM_001160209.1 → NP_001153681.1  golgin-45 isoform b

      See identical proteins and their annotated locations for NP_001153681.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon and differs in the 5' UTR compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode isoform b.
      Source sequence(s)
      AC105161, AK029787, AK167493
      Consensus CDS
      CCDS48423.1
      UniProtKB/Swiss-Prot
      Q3TJC4, Q8C0U6, Q8R2X8, Q9DAV7
      UniProtKB/TrEMBL
      Q3TBM0, Q3V485
      Related
      ENSMUSP00000113479.2, ENSMUST00000120447.8
      Conserved Domains (1) summary
      pfam08227
      Location:184 → 229
      DASH_Hsk3; DASH complex subunit Hsk3 like

    3. NM_001357052.1 → NP_001343981.1  golgin-45 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC105161
      UniProtKB/TrEMBL
      Q3V485
      Conserved Domains (2) summary
      pfam08227
      Location:157 → 202
      DASH_Hsk3; DASH complex subunit Hsk3 like
      cl25732
      Location:76 → 247
      SMC_N; RecF/RecN/SMC N terminal domain

    4. NM_025505.4 → NP_079781.2  golgin-45 isoform a

      See identical proteins and their annotated locations for NP_079781.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC105161, AK029787
      Consensus CDS
      CCDS15435.1
      UniProtKB/TrEMBL
      Q3TBM0, Q3V485
      Related
      ENSMUSP00000027866.5, ENSMUST00000027866.11
      Conserved Domains (1) summary
      pfam08227
      Location:191 → 236
      DASH_Hsk3; DASH complex subunit Hsk3 like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      164117368..164135056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R2X8.2 GenPept UniProtKB/Swiss-Prot:Q8R2X8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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