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    Dmac2 distal membrane arm assembly complex 2 [ Mus musculus (house mouse) ]

    Gene ID: 66349, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Dmac2provided by MGI
    Official Full Name
    distal membrane arm assembly complex 2provided by MGI
    Primary source
    MGI:MGI:1913599
    See related
    Ensembl:ENSMUSG00000057229 AllianceGenome:MGI:1913599
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Atp5sl; 2310004L02Rik; C030044E10Rik
    Summary
    Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Orthologous to human DMAC2 (distal membrane arm assembly component 2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 27.8), kidney adult (RPKM 26.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dmac2 in Genome Data Viewer
    Location:
    7 A3; 7 13.93 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (25318839..25324975)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (25619414..25625550)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L15 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9286 Neighboring gene glutamate rich 4 Neighboring gene predicted gene, 38969 Neighboring gene predicted gene, 57782 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 Neighboring gene branched chain ketoacid dehydrogenase E1, alpha polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E8156 Neighboring gene STARR-positive B cell enhancer ABC_E10430 Neighboring gene STARR-seq mESC enhancer starr_18309

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    part_of respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    distal membrane-arm assembly complex protein 2
    Names
    ATP synthase subunit s-like protein
    ATP5S-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290487.1 → NP_001277416.1  distal membrane-arm assembly complex protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001277416.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC162614, AK009150
      Consensus CDS
      CCDS71917.1
      UniProtKB/Swiss-Prot
      Q9D7K5
      UniProtKB/TrEMBL
      Q9DCX4
      Related
      ENSMUSP00000076563.6, ENSMUST00000077338.12
      Conserved Domains (2) summary
      cd09293
      Location:149 → 221
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:151 → 176
      LRR_AMN1; leucine-rich repeat [structural motif]

    2. NM_025504.4 → NP_079780.2  distal membrane-arm assembly complex protein 2 isoform 2

      See identical proteins and their annotated locations for NP_079780.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate first exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC162614
      Consensus CDS
      CCDS20988.1
      UniProtKB/TrEMBL
      Q8CA44, Q9DCX4
      Related
      ENSMUSP00000083115.4, ENSMUST00000085953.5
      Conserved Domains (2) summary
      cd09293
      Location:148 → 220
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:150 → 175
      LRR_AMN1; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      25318839..25324975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D7K5.1 GenPept UniProtKB/Swiss-Prot:Q9D7K5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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