U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Aamdc adipogenesis associated Mth938 domain containing [ Mus musculus (house mouse) ]

    Gene ID: 66273, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Aamdcprovided by MGI
    Official Full Name
    adipogenesis associated Mth938 domain containingprovided by MGI
    Primary source
    MGI:MGI:1913523
    See related
    Ensembl:ENSMUSG00000035642 AllianceGenome:MGI:1913523
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LI2; 1810020D17Rik; 1810037D19Rik
    Summary
    Acts upstream of or within negative regulation of apoptotic process; positive regulation of fat cell differentiation; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm. Is expressed in central nervous system; embryo; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human AAMDC (adipogenesis associated Mth938 domain containing). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 15.8), kidney adult (RPKM 15.1) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Aamdc in Genome Data Viewer
    Location:
    7 E1; 7 53.54 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (97199538..97228723, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (97550329..97579557, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerisation domain containing 14 Neighboring gene STARR-positive B cell enhancer ABC_E4950 Neighboring gene integrator complex subunit 4 Neighboring gene predicted gene, 24412 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta, pseudogene 1 Neighboring gene ribosomal protein L15, pseudogene 5 Neighboring gene remodeling and spacing factor 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of fat cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    mth938 domain-containing protein
    Names
    UPF0366 protein C11orf67 homolog

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177945.1 → NP_001171416.1  mth938 domain-containing protein isoform 1

      See identical proteins and their annotated locations for NP_001171416.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC149605, AW124043, BC062811, BY259812
      Consensus CDS
      CCDS52316.1
      UniProtKB/TrEMBL
      D3YWY5, D3YZD8
      Related
      ENSMUSP00000115672.2, ENSMUST00000154853.8
      Conserved Domains (1) summary
      cd05126
      Location:33 → 148
      Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...

    2. NM_001177946.1 → NP_001171417.1  mth938 domain-containing protein isoform 3

      See identical proteins and their annotated locations for NP_001171417.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AC149605, BC062811, BY259812
      Consensus CDS
      CCDS52315.1
      UniProtKB/TrEMBL
      D3Z1Q3
      Related
      ENSMUSP00000072508.6, ENSMUST00000072725.12
      Conserved Domains (1) summary
      cl00182
      Location:33 → 116
      Mth938-like; Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a ...

    3. NM_001177947.1 → NP_001171418.1  mth938 domain-containing protein isoform 4

      See identical proteins and their annotated locations for NP_001171418.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks two coding exons, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AC149605, AK008195, BC062811, BY259812
      Consensus CDS
      CCDS52314.1
      UniProtKB/Swiss-Prot
      Q8R0P4
      Related
      ENSMUSP00000116214.2, ENSMUST00000138060.3
      Conserved Domains (1) summary
      cl00182
      Location:5 → 88
      Mth938-like; Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a ...

    4. NM_183251.3 → NP_899074.2  mth938 domain-containing protein isoform 2

      See identical proteins and their annotated locations for NP_899074.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AA065573, AC149605, BC062811, BY259812
      Consensus CDS
      CCDS21461.1
      UniProtKB/Swiss-Prot
      Q8BH71, Q8R0P4
      UniProtKB/TrEMBL
      D3Z442
      Related
      ENSMUSP00000121940.2, ENSMUST00000136757.8
      Conserved Domains (1) summary
      cd05126
      Location:5 → 120
      Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      97199538..97228723 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508114.5 → XP_006508177.1  mth938 domain-containing protein isoform X1

      See identical proteins and their annotated locations for XP_006508177.1

      UniProtKB/Swiss-Prot
      Q8BH71, Q8R0P4
      UniProtKB/TrEMBL
      D3Z442
      Conserved Domains (1) summary
      cd05126
      Location:5 → 120
      Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R0P4.1 GenPept UniProtKB/Swiss-Prot:Q8R0P4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools