U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Sptssb serine palmitoyltransferase, small subunit B [ Mus musculus (house mouse) ]

    Gene ID: 66183, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Sptssbprovided by MGI
    Official Full Name
    serine palmitoyltransferase, small subunit Bprovided by MGI
    Primary source
    MGI:MGI:1913433
    See related
    Ensembl:ENSMUSG00000043461 AllianceGenome:MGI:1913433
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ADMP; Sssptb; 1110032A04Rik
    Summary
    Contributes to serine C-palmitoyltransferase activity. Acts upstream of or within ceramide biosynthetic process; endoplasmic reticulum organization; and regulation of serine C-palmitoyltransferase activity. Part of serine palmitoyltransferase complex. Is expressed in central nervous system; eye; genitourinary system; and gut. Orthologous to human SPTSSB (serine palmitoyltransferase small subunit B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in bladder adult (RPKM 217.4) and stomach adult (RPKM 59.8) See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Sptssb in Genome Data Viewer
    Location:
    3 E2; 3 32.3 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (69726871..69768697, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (69819538..69861363, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene NMD3 ribosome export adaptor Neighboring gene predicted gene, 52662 Neighboring gene STARR-seq mESC enhancer starr_07931 Neighboring gene ribosome production factor 2 homolog pseudogene Neighboring gene predicted gene, 52608 Neighboring gene predicted gene, 35817 Neighboring gene nucleophosmin 1 pseudogene

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular cloning and characterization of a novel androgen repressible gene expressed in the prostate epithelium. Singh J, et al. Gene, 2005 Mar 28. PMID 15777716
    2. Elevation of 20-carbon long chain bases due to a mutation in serine palmitoyltransferase small subunit b results in neurodegeneration. Zhao L, et al. Proc Natl Acad Sci U S A, 2015 Oct 20. PMID 26438849, Free PMC Article
    3. Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities. Han G, et al. Proc Natl Acad Sci U S A, 2009 May 19. PMID 19416851, Free PMC Article
    4. Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil. Lau CG, et al. Mol Reprod Dev, 2014 Nov. PMID 25269881
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Targeted (2) 

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to serine C-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to serine C-palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to serine C-palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to serine C-palmitoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ceramide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within endoplasmic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of serine C-palmitoyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sphingolipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sphingosine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingosine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of serine palmitoyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of serine palmitoyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of serine palmitoyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of serine palmitoyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    serine palmitoyltransferase small subunit B
    Names
    androgen down regulated in mouse prostate
    small subunit of serine palmitoyltransferase B

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164210.2 → NP_001157682.1  serine palmitoyltransferase small subunit B isoform a

      See identical proteins and their annotated locations for NP_001157682.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 encode the same protein (isoform a).
      Source sequence(s)
      AC122009, AK004017, AK009973, BC022628
      Consensus CDS
      CCDS38453.1
      UniProtKB/Swiss-Prot
      Q925E8
      Related
      ENSMUSP00000131241.2, ENSMUST00000171529.4
      Conserved Domains (1) summary
      pfam11779
      Location:7 → 60
      SPT_ssu-like; Small subunit of serine palmitoyltransferase-like

    2. NM_001286959.1 → NP_001273888.1  serine palmitoyltransferase small subunit B isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has a different 3' structure which results in a frameshift compared to variant 1. The resulting isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AC122009
      Conserved Domains (1) summary
      pfam11779
      Location:7 → 57
      DUF3317; Protein of unknown function (DUF3317)

    3. NM_133675.3 → NP_598436.1  serine palmitoyltransferase small subunit B isoform a

      See identical proteins and their annotated locations for NP_598436.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform a).
      Source sequence(s)
      AC122009, AK004017, BC022628
      Consensus CDS
      CCDS38453.1
      UniProtKB/Swiss-Prot
      Q925E8
      Related
      ENSMUSP00000062794.8, ENSMUST00000051239.13
      Conserved Domains (1) summary
      pfam11779
      Location:7 → 60
      SPT_ssu-like; Small subunit of serine palmitoyltransferase-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      69726871..69768697 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252751.2 → XP_030108611.1  serine palmitoyltransferase small subunit B isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q925E8.1 GenPept UniProtKB/Swiss-Prot:Q925E8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous