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    Pgls 6-phosphogluconolactonase [ Mus musculus (house mouse) ]

    Gene ID: 66171, updated on 11-Nov-2024

    Summary

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    Official Symbol
    Pglsprovided by MGI
    Official Full Name
    6-phosphogluconolactonaseprovided by MGI
    Primary source
    MGI:MGI:1913421
    See related
    Ensembl:ENSMUSG00000031807 AllianceGenome:MGI:1913421
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Plgs; 1110030K05Rik
    Summary
    Predicted to enable 6-phosphogluconolactonase activity and monosaccharide binding activity. Predicted to be involved in pentose-phosphate shunt, oxidative branch. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in cerebellum; hemolymphoid system; and thymus primordium. Orthologous to human PGLS (6-phosphogluconolactonase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 208.2), ovary adult (RPKM 111.5) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pgls in Genome Data Viewer
    Location:
    8 B3.3; 8 34.43 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (72044828..72048911)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71592184..71596267)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene nucleoredoxin-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E10508 Neighboring gene solute carrier family 27 (fatty acid transporter), member 1 Neighboring gene niban apoptosis regulator 3 Neighboring gene STARR-positive B cell enhancer ABC_E9025 Neighboring gene collagen beta(1-O)galactosyltransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. 547 transcriptomes from 44 brain areas reveal features of the aging brain in non-human primates. Li ML, et al. Genome Biol, 2019 Nov 28. PMID 31779658, Free PMC Article
    2. γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A. Gao X, et al. Mol Cell, 2019 Dec 19. PMID 31586547, Free PMC Article
    3. NMR spectroscopic analysis of the first two steps of the pentose-phosphate pathway elucidates the role of 6-phosphogluconolactonase. Miclet E, et al. J Biol Chem, 2001 Sep 14. PMID 11457850
    4. Deciphering the metabolic heterogeneity of hematopoietic stem cells with single-cell resolution. Cao J, et al. Cell Metab, 2024 Jan 2. PMID 38171334
    5. Investigation of differentially expressed genes during the development of mouse cerebellum. Kagami Y, et al. Brain Res Gene Expr Patterns, 2001 Aug. PMID 15018818

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. hub gene underlying brain aging
      Title: 547 transcriptomes from 44 brain areas reveal features of the aging brain in non-human primates.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 6-phosphogluconolactonase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 6-phosphogluconolactonase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables monosaccharide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose-phosphate shunt ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pentose-phosphate shunt, oxidative branch IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pentose-phosphate shunt, oxidative branch ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    6-phosphogluconolactonase
    Names
    6PGL
    NP_001281198.1
    NP_079672.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001294269.1 → NP_001281198.1  6-phosphogluconolactonase isoform 2

      See identical proteins and their annotated locations for NP_001281198.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC162033, AK003134, AK003985, BE654173
      Consensus CDS
      CCDS80895.1
      UniProtKB/TrEMBL
      D3Z4X1
      Related
      ENSMUSP00000116524.2, ENSMUST00000143441.2
      Conserved Domains (1) summary
      cd01400
      Location:15 → 156
      6PGL; 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard ...

    2. NM_025396.3 → NP_079672.1  6-phosphogluconolactonase isoform 1

      See identical proteins and their annotated locations for NP_079672.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC162033
      Consensus CDS
      CCDS22400.1
      UniProtKB/Swiss-Prot
      Q3TA62, Q9CQ60
      UniProtKB/TrEMBL
      Q8CBG6
      Related
      ENSMUSP00000034264.5, ENSMUST00000034264.11
      Conserved Domains (1) summary
      TIGR01198
      Location:11 → 247
      pgl; 6-phosphogluconolactonase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      72044828..72048911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQ60.1 GenPept UniProtKB/Swiss-Prot:Q9CQ60

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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