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    Ufc1 ubiquitin-fold modifier conjugating enzyme 1 [ Mus musculus (house mouse) ]

    Gene ID: 66155, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ufc1provided by MGI
    Official Full Name
    ubiquitin-fold modifier conjugating enzyme 1provided by MGI
    Primary source
    MGI:MGI:1913405
    See related
    Ensembl:ENSMUSG00000062963 AllianceGenome:MGI:1913405
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ESTM29; 1110021H02Rik
    Summary
    Enables UFM1 conjugating enzyme activity. Involved in protein ufmylation and regulation of type II interferon production. Is expressed in chondrocranium and liver. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with spasticity and poor growth. Orthologous to human UFC1 (ubiquitin-fold modifier conjugating enzyme 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 26.0), placenta adult (RPKM 25.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ufc1 in Genome Data Viewer
    Location:
    1 H3; 1 79.31 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171116137..171122575, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171288564..171295002, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene protoporphyrinogen oxidase Neighboring gene STARR-positive B cell enhancer mm9_chr1:173211225-173211526 Neighboring gene STARR-positive B cell enhancer mm9_chr1:173211857-173212158 Neighboring gene ubiquitin specific peptidase 21 Neighboring gene STARR-seq mESC enhancer starr_03026 Neighboring gene STARR-seq mESC enhancer starr_03027 Neighboring gene ribosomal protein L27, pseudogene 1 Neighboring gene predicted gene, 25151

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ubiquitin-fold modifier 1 inhibits apoptosis by suppressing the endoplasmic reticulum stress response in Raw264.7 cells. Hu X, et al. Int J Mol Med, 2014 Jun. PMID 24714921
    2. UFMylation inhibits the proinflammatory capacity of interferon-γ-activated macrophages. Balce DR, et al. Proc Natl Acad Sci U S A, 2021 Jan 5. PMID 33372156, Free PMC Article
    3. Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking. Zhang Y, et al. PLoS One, 2012. PMID 23152784, Free PMC Article
    4. CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development. Yang R, et al. Development, 2019 Jan 25. PMID 30635284
    5. Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). Eddleston J, et al. Genomics, 1999 Mar 1. PMID 10051400

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results suggest that Ufm1 is upregulated in diabetic mouse RPMs and in Raw264.7 cells in response to ER stress and that Ufm1 protects macrophages against apoptosis.
      Title: Ubiquitin-fold modifier 1 inhibits apoptosis by suppressing the endoplasmic reticulum stress response in Raw264.7 cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables UFM1 conjugating enzyme activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables UFM1 conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables UFM1 transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in brain development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K69-linked ufmylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K69-linked ufmylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ufmylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein ufmylation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in protein ufmylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of type II interferon production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in reticulophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reticulophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in reticulophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-fold modifier-conjugating enzyme 1
    Names
    Ufm1-conjugating enzyme 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360931.1 → NP_001347860.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC087229
      Consensus CDS
      CCDS15488.1
      UniProtKB/Swiss-Prot
      Q9CR09
      Related
      ENSMUSP00000106933.4, ENSMUST00000111302.4
      Conserved Domains (1) summary
      pfam08694
      Location:6 → 160
      UFC1; Ubiquitin-fold modifier-conjugating enzyme 1

    2. NM_001360932.1 → NP_001347861.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC087229, AI596556, BE652094
      Consensus CDS
      CCDS15488.1
      UniProtKB/Swiss-Prot
      Q9CR09
      Conserved Domains (1) summary
      pfam08694
      Location:6 → 160
      UFC1; Ubiquitin-fold modifier-conjugating enzyme 1

    3. NM_001360933.1 → NP_001347862.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC087229, AI596556
      Conserved Domains (1) summary
      pfam08694
      Location:6 → 80
      UFC1; Ubiquitin-fold modifier-conjugating enzyme 1

    4. NM_025388.3 → NP_079664.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform a

      See identical proteins and their annotated locations for NP_079664.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC087229, AK003897
      Consensus CDS
      CCDS15488.1
      UniProtKB/Swiss-Prot
      Q9CR09
      Related
      ENSMUSP00000078914.3, ENSMUST00000080001.9
      Conserved Domains (1) summary
      pfam08694
      Location:6 → 160
      UFC1; Ubiquitin-fold modifier-conjugating enzyme 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      171116137..171122575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CR09.1 GenPept UniProtKB/Swiss-Prot:Q9CR09

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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