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    Wdr7 WD repeat domain 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 66031, updated on 2-Nov-2024

    Summary

    Official Symbol
    Wdr7provided by RGD
    Official Full Name
    WD repeat domain 7provided by RGD
    Primary source
    RGD:619836
    See related
    EnsemblRapid:ENSRNOG00000018387 AllianceGenome:RGD:619836
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Wd7; Trag
    Summary
    Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Is active in synaptic vesicle. Orthologous to human WDR7 (WD repeat domain 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 325.9), Thymus (RPKM 206.2) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Wdr7 in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (59435733..59718800)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (57165482..57448568)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (59096636..59396312)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482983 Neighboring gene thioredoxin-like 1 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC108348800 Neighboring gene ribosomal protein L31 like 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    WD repeat-containing protein 7
    Names
    TGF-beta resistance-associated protein TRAG
    rabconnectin-3beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395078.1NP_001382007.1  WD repeat-containing protein 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A8I5ZVH0, A6IXN0
      Conserved Domains (3) summary
      COG2319
      Location:19199
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:2262
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:407594
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_023975.2NP_076465.1  WD repeat-containing protein 7 isoform 1

      See identical proteins and their annotated locations for NP_076465.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/Swiss-Prot
      Q920I8, Q9ERH3
      UniProtKB/TrEMBL
      A0A8I5ZVH0, A6IXM9
      Related
      ENSRNOP00000025325.3, ENSRNOT00000025325.5
      Conserved Domains (3) summary
      COG2319
      Location:341592
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:2262
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:407594
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      59435733..59718800
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601032.3XP_017456521.1  WD repeat-containing protein 7 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZVH0
    2. XM_063277569.1XP_063133639.1  WD repeat-containing protein 7 isoform X2

      UniProtKB/TrEMBL
      A6IXN0
      Related
      ENSRNOP00000082010.2, ENSRNOT00000110066.2
    3. XM_063277568.1XP_063133638.1  WD repeat-containing protein 7 isoform X1

      UniProtKB/Swiss-Prot
      Q920I8, Q9ERH3
      UniProtKB/TrEMBL
      A6IXM9