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    rpa2 replication protein A2 [ Danio rerio (zebrafish) ]

    Gene ID: 65226, updated on 2-Nov-2024

    Summary

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    Official Symbol
    rpa2provided by ZNC
    Official Full Name
    replication protein A2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010131-3
    See related
    Ensembl:ENSDARG00000037188 AllianceGenome:ZFIN:ZDB-GENE-010131-3
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    rpa; zgc:109822; ik:tdsubc_2g1; xx:tdsubc_2g1
    Summary
    Predicted to enable single-stranded DNA binding activity and telomeric DNA binding activity. Predicted to be involved in DNA replication; double-strand break repair via homologous recombination; and nucleotide-excision repair. Predicted to act upstream of or within DNA recombination and DNA repair. Predicted to be located in nucleus. Predicted to be part of DNA replication factor A complex. Predicted to be active in chromosome, telomeric region and site of double-strand break. Orthologous to human RPA2 (replication protein A2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rpa2 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (4746593..4769967, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (4917304..4940678, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene mitochondrial trans-2-enoyl-CoA reductase Neighboring gene sphingomyelin phosphodiesterase acid like 3B Neighboring gene thymocyte selection associated family member 2 Neighboring gene ubiquitin protein ligase E3D Neighboring gene trophoblast glycoprotein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of replication protein A p32 complementary DNA in zebrafish (Danio rerio). Lee JS, et al. Mar Biotechnol (NY), 2002 Jan. PMID 14961282
    2. Characterization of zebrafish Rad52 and replication protein A for oligonucleotide-mediated mutagenesis. Takahashi N, et al. Nucleic Acids Res, 2005 Aug 1. PMID 16061934, Free PMC Article
    3. leptin b and its regeneration enhancer illustrate the regenerative features of zebrafish hearts. Shin K, et al. Dev Dyn, 2024 Jan. PMID 36495292,
    4. Epigenetic Studies Point to DNA Replication/Repair Genes as a Basis for the Heritable Nature of Long Term Complications in Diabetes. Leontovich AA, et al. J Diabetes Res, 2016. PMID 26981540, Free PMC Article
    5. Mettl3 Mutation Disrupts Gamete Maturation and Reduces Fertility in Zebrafish. Xia H, et al. Genetics, 2018 Feb. PMID 29196300, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA replication factor A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in chromosome, telomeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in site of double-strand break IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    replication protein A 32 kDa subunit
    Names
    RPA p32

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131711.2 → NP_571786.2  replication protein A 32 kDa subunit

      See identical proteins and their annotated locations for NP_571786.2

      Status: VALIDATED

      Source sequence(s)
      BC095005
      UniProtKB/TrEMBL
      B5DDC8, F6NPP7, Q504I6
      Related
      ENSDARP00000054077.6, ENSDART00000054078.8
      Conserved Domains (3) summary
      COG5235
      Location:20 → 267
      RFA2; Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit [DNA replication, recombination, and repair]
      cd04478
      Location:69 → 163
      RPA2_DBD_D; RPA2_DBD_D: A subfamily of OB folds corresponding to the OB fold of the central ssDNA-binding domain (DBD)-D of human RPA2 (also called RPA32). RPA2 is a subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears ...
      pfam08784
      Location:162 → 262
      RPA_C; Replication protein A C terminal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      4746593..4769967 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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