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    Cap1 cyclase associated actin cytoskeleton regulatory protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64185, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cap1provided by RGD
    Official Full Name
    cyclase associated actin cytoskeleton regulatory protein 1provided by RGD
    Primary source
    RGD:620309
    See related
    EnsemblRapid:ENSRNOG00000013492 AllianceGenome:RGD:620309
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mch1
    Summary
    Predicted to enable actin binding activity and adenylate cyclase binding activity. Predicted to be involved in several processes, including actin filament organization; cAMP-mediated signaling; and modification of postsynaptic actin cytoskeleton. Predicted to act upstream of or within actin cytoskeleton organization; ameboidal-type cell migration; and receptor-mediated endocytosis. Predicted to be located in cortical actin cytoskeleton. Predicted to be active in several cellular components, including glutamatergic synapse; postsynapse; and presynapse. Orthologous to human CAP1 (cyclase associated actin cytoskeleton regulatory protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 734.1), Thymus (RPKM 537.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cap1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (140427265..140507678, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (135142108..135168885, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (140559195..140585494, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene twinfilin actin-binding protein 1, pseudogene 1 Neighboring gene uncharacterized LOC120102972 Neighboring gene palmitoyl-protein thioesterase 1 Neighboring gene uncharacterized LOC100909490 Neighboring gene MFSD2 lysolipid transporter A, lysophospholipid Neighboring gene MYCL proto-oncogene, bHLH transcription factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The expression of CAP1 after traumatic brain injury and its role in astrocyte proliferation. Zhang H, et al. J Mol Neurosci, 2014 Dec. PMID 25060335
    2. CAP1 was associated with actin and involved in Schwann cell differentiation and motility after sciatic nerve injury. Zhu X, et al. J Mol Histol, 2014 Jun. PMID 24272071
    3. Molecular cloning and characterization of a rat homolog of CAP, the adenylyl cyclase-associated protein from Saccharomyces cerevisiae. Zelicof A, et al. J Biol Chem, 1993 Jun 25. PMID 8514780
    4. Expression and function of neuronal growth-associated proteins (nGAPs) in PC12 cells. Lu J, et al. Neurosci Res, 2011 May. PMID 21238513
    5. Identification and characterization of a cDNA encoding mouse CAP: a homolog of the yeast adenylyl cyclase associated protein. Vojtek AB, et al. J Cell Sci, 1993 Jul. PMID 7691848

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CAP1 binds and activates adenylyl cyclase in mammalian cells.
      Title: CAP1 binds and activates adenylyl cyclase in mammalian cells.
    2. Hippocampal Cap1 levels is sensitive to different exercise intensities.Highest corticosterone level and lactate production leads to reduction and induction of hippocampal Cap1.
      Title: Various exercise intensities differentially regulate GAP-43 and CAP-1 expression in the rat hippocampus.
    3. Upregulation of CAP1 protein expression was associated with astrocyte proliferation after the trauma of the central nervous system.
      Title: The expression of CAP1 after traumatic brain injury and its role in astrocyte proliferation.
    4. CAP1 was associated with actin and involved in Schwann cell differentiation and motility after sciatic nerve injury.
      Title: CAP1 was associated with actin and involved in Schwann cell differentiation and motility after sciatic nerve injury.
    5. Cap1 regulates growth cone morphology through rearrangement of F-actin and thereby controls neurite outgrowth.
      Title: Expression and function of neuronal growth-associated proteins (nGAPs) in PC12 cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108691

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate cyclase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ameboidal-type cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ameboidal-type cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in modification of postsynaptic actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in modification of postsynaptic actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in receptor-mediated endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cortical actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cortical actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    adenylyl cyclase-associated protein 1
    Names
    CAP 1
    CAP, adenylate cyclase-associated protein 1
    adenylate cyclase associated protein 1
    cyclase-associated protein homologue

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430080.1 → NP_001417009.1  adenylyl cyclase-associated protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q08163, Q5FVS8
      UniProtKB/TrEMBL
      A6IS11

    2. NM_001430081.1 → NP_001417010.1  adenylyl cyclase-associated protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q08163, Q5FVS8
      UniProtKB/TrEMBL
      A6IS11

    3. NM_001430082.1 → NP_001417011.1  adenylyl cyclase-associated protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q08163, Q5FVS8
      UniProtKB/TrEMBL
      A6IS11

    4. NM_001430083.1 → NP_001417012.1  adenylyl cyclase-associated protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q08163, Q5FVS8
      UniProtKB/TrEMBL
      A6IS11

    5. NM_001430084.1 → NP_001417013.1  adenylyl cyclase-associated protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q08163, Q5FVS8
      UniProtKB/TrEMBL
      A6IS11

    6. NM_001430085.1 → NP_001417014.1  adenylyl cyclase-associated protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q08163, Q5FVS8
      UniProtKB/TrEMBL
      A6IS11

    7. NM_001430086.1 → NP_001417015.1  adenylyl cyclase-associated protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q08163, Q5FVS8
      UniProtKB/TrEMBL
      A6IS11

    8. NM_001430087.1 → NP_001417016.1  adenylyl cyclase-associated protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q08163, Q5FVS8
      UniProtKB/TrEMBL
      A6IS11

    9. NM_022383.5 → NP_071778.2  adenylyl cyclase-associated protein 1

      See identical proteins and their annotated locations for NP_071778.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q08163, Q5FVS8
      UniProtKB/TrEMBL
      A0A8L2QAE6, A6IS11
      Related
      ENSRNOP00000018711.5, ENSRNOT00000018711.6
      Conserved Domains (2) summary
      pfam01213
      Location:5 → 61
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:318 → 472
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      140427265..140507678 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288342.1 → XP_063144412.1  adenylyl cyclase-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q08163, Q5FVS8
      UniProtKB/TrEMBL
      A6IS11

    2. XM_063288341.1 → XP_063144411.1  adenylyl cyclase-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q08163, Q5FVS8
      UniProtKB/TrEMBL
      A6IS11

    3. XM_039110702.2 → XP_038966630.1  adenylyl cyclase-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q08163, Q5FVS8
      UniProtKB/TrEMBL
      A0A8L2QAE6, A6IS11
      Conserved Domains (2) summary
      pfam01213
      Location:5 → 61
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:318 → 472
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    4. XM_063288346.1 → XP_063144416.1  adenylyl cyclase-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q08163, Q5FVS8
      UniProtKB/TrEMBL
      A6IS11

    5. XM_006238830.5 → XP_006238892.1  adenylyl cyclase-associated protein 1 isoform X1

      Conserved Domains (2) summary
      pfam01213
      Location:5 → 61
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:318 → 472
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    6. XM_006238832.5 → XP_006238894.1  adenylyl cyclase-associated protein 1 isoform X1

      Conserved Domains (2) summary
      pfam01213
      Location:5 → 61
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:318 → 472
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    7. XM_006238831.5 → XP_006238893.1  adenylyl cyclase-associated protein 1 isoform X1

      Conserved Domains (2) summary
      pfam01213
      Location:5 → 61
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:318 → 472
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    8. XM_063288340.1 → XP_063144410.1  adenylyl cyclase-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q08163, Q5FVS8
      UniProtKB/TrEMBL
      A6IS11

    9. XM_063288344.1 → XP_063144414.1  adenylyl cyclase-associated protein 1 isoform X1

    10. XM_063288345.1 → XP_063144415.1  adenylyl cyclase-associated protein 1 isoform X1

    11. XM_063288343.1 → XP_063144413.1  adenylyl cyclase-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q08163, Q5FVS8
      UniProtKB/TrEMBL
      A6IS11

    12. XM_039110703.2 → XP_038966631.1  adenylyl cyclase-associated protein 1 isoform X1

      Conserved Domains (2) summary
      pfam01213
      Location:5 → 61
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:318 → 472
      CAP_C; Adenylate cyclase associated (CAP) C terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08163.3 GenPept UniProtKB/Swiss-Prot:Q08163

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