ERVK-6 endogenous retrovirus group K member 6, envelope [Homo sapiens (human)] - Gene

Summary

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Official Symbol: ERVK-6provided by HGNC
Official Full Name: endogenous retrovirus group K member 6, envelopeprovided by HGNC
Primary source: HGNC:HGNC:13915
See related: MIM:605626
Gene type: other
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: cORF; ERVK6; K-Rev; c-orf; envK2; HERV-K108; HERV-K(C7)
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Genomic context

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Location:: 7p22.1

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 controllers exhibit an enhanced antiretroviral innate state characterised by overexpression of p21 and MCPIP1 and silencing of ERVK-6 RNA expression.
Title: HIV-1 controllers exhibit an enhanced antiretroviral innate state characterised by overexpression of p21 and MCPIP1 and silencing of ERVK-6 RNA expression.
Up-regulation of the endogenous retrovirus HERV-K initiates and sustains activation of the immune system and causes vascular changes associated with pulmonary arterial hypertension.
Title: Upregulation of Human Endogenous Retrovirus-K Is Linked to Immunity and Inflammation in Pulmonary Arterial Hypertension.
ERVK6 gene insertion polymorphisms are associated with lung cancer.
Title: Identification and association study with lung cancer for novel insertion polymorphisms of human endogenous retrovirus.
Here, it was shown that human endogenous retrovirus Rec can form a trimeric complex with TZFP and AR, and can relieve the TZFP-mediated repression of AR-induced transactivation.
Title: Human endogenous retrovirus protein Rec interacts with the testicular zinc-finger protein and androgen receptor.
ERVK6 translocates Env into the endoplasmic reticulum lumen.
Title: Human endogenous retrovirus HERV-K(HML-2) encodes a stable signal peptide with biological properties distinct from Rec.
HERV-K rec has a role in disturbed germ cell development
Title: Human endogenous retrovirus rec interferes with germ cell development in mice and may cause carcinoma in situ, the predecessor lesion of germ cell tumors.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D6S2277 (e-PCR)
- UniSTS:59918

D22S1651 (e-PCR)
- UniSTS:474031

Other Names

Endogenous retrovirus group K member 6 Env polyprotein
Envelope polyprotein
HERV-K (HML-2.HOM)
HERV-K(C7) envelope protein
HERV-K(HML-2.HOM) envelope protein
HERV-K108 envelope protein
HERV-K_7p22.1 provirus Rec protein
HERV-K_7p22.1 provirus ancestral Env polyprotein
HERV-K_7p22.1 provirus ancestral Pol protein
HERV-K_7p22.1 provirus ancestral Pro protein
Rev-like protein
Rev/Rex homolog
endogenous retroviral sequence K, 6
endogenous retrovirus group K, member 6
envelope glycoprotein
envelope protein

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA stem-loop binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA stem-loop binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA-DNA hybrid ribonuclease activity	IEA Inferred from Electronic Annotation more info
enables RNA-directed DNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables aspartic-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables structural molecule activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA integration	IEA Inferred from Electronic Annotation more info
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA synthesis involved in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA-templated DNA replication	IEA Inferred from Electronic Annotation more info
involved_in RNA-templated DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in mRNA export from nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein homooligomerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
NOT involved_in syncytium formation by plasma membrane fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in viral translational frameshifting	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IMP Inferred from Mutant Phenotype more info	PubMed

NCBI Reference Sequences (RefSeq)

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Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001007236.1: Suppressed sequence

Description

NM_001007236.1: This RefSeq was permanently discontinued as it represents an expressed retrovirus and is considered out of scope.

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q69383.1	GenPept	UniProtKB/Swiss-Prot:Q69383
Q69384.1	GenPept	UniProtKB/Swiss-Prot:Q69384
Q7LDI9.3	GenPept	UniProtKB/Swiss-Prot:Q7LDI9
Q9BXR3.2	GenPept	UniProtKB/Swiss-Prot:Q9BXR3
Q9Y6I0.2	GenPept	UniProtKB/Swiss-Prot:Q9Y6I0