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    Bco1 beta-carotene oxygenase 1 [ Mus musculus (house mouse) ]

    Gene ID: 63857, updated on 28-Oct-2024

    Summary

    Official Symbol
    Bco1provided by MGI
    Official Full Name
    beta-carotene oxygenase 1provided by MGI
    Primary source
    MGI:MGI:1926923
    See related
    Ensembl:ENSMUSG00000031845 AllianceGenome:MGI:1926923
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bcdo; CMO1; Cmoi; Bcdo1; Bcmo1; beta-CD; betaCMOOX
    Summary
    Vitamin A metabolism is important for vital processes such as vision, embryonic development, cell differentiation, and membrane and skin protection. The protein encoded by this gene is a key enzyme in beta-carotene metabolism to vitamin A. It catalyzes the oxidative cleavage of beta,beta-carotene into two retinal molecules. Two alternatively spliced variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
    Expression
    Biased expression in testis adult (RPKM 9.3), liver E18 (RPKM 2.0) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Bco1 in Genome Data Viewer
    Location:
    8 E1; 8 63.61 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (117822590..117860459)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (117095851..117133720)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene polycystic kidney disease 1 like 2 Neighboring gene predicted gene, 31519 Neighboring gene predicted gene 15395 Neighboring gene STARR-seq mESC enhancer starr_22807 Neighboring gene STARR-positive B cell enhancer ABC_E8266 Neighboring gene STARR-positive B cell enhancer ABC_E2275 Neighboring gene giant axonal neuropathy Neighboring gene STARR-positive B cell enhancer mm9_chr8:119748493-119748794 Neighboring gene STARR-seq mESC enhancer starr_22810 Neighboring gene STARR-seq mESC enhancer starr_22812 Neighboring gene c-Maf inducing protein Neighboring gene predicted gene, 51554

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-carotene 15,15'-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables beta-carotene 15,15'-dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables beta-carotene 15,15'-dioxygenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables beta-carotene 15,15'-dioxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables beta-carotene 15,15'-dioxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables carotenoid dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within beta-carotene metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in carotene catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in carotene catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in carotene catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in carotene catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retinal metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within retinal metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in retinal metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retinal metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retinoid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in retinoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    beta,beta-carotene 15,15'-dioxygenase
    Names
    beta,beta-carotene 15,15'-monooxygenase
    beta-carotene 15, 15'-dioxygenase 1
    beta-carotene 15,15' dioxygenase
    beta-carotene 15,15'-monooxygenase
    beta-carotene cleavage enzyme
    beta-carotene dioxygenase 1
    carotenoid-15,15'-oxygenase
    NP_001156500.1
    NP_067461.2
    XP_011246783.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163028.2NP_001156500.1  beta,beta-carotene 15,15'-dioxygenase isoform 2

      See identical proteins and their annotated locations for NP_001156500.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an alternate exon in the 3' coding region resulting in a frameshift, compared to variant 1. It encodes isoform 2 which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC108436, AC121116, AEKQ02009580
      Consensus CDS
      CCDS52679.1
      UniProtKB/TrEMBL
      E9Q321
      Related
      ENSMUSP00000134815.2, ENSMUST00000176860.2
      Conserved Domains (1) summary
      pfam03055
      Location:11471
      RPE65; Retinal pigment epithelial membrane protein
    2. NM_021486.4NP_067461.2  beta,beta-carotene 15,15'-dioxygenase isoform 1

      See identical proteins and their annotated locations for NP_067461.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
      Source sequence(s)
      AC108436, AC121116, AEKQ02009580
      Consensus CDS
      CCDS22697.1
      UniProtKB/Swiss-Prot
      Q6K1L5, Q8C6N5, Q9ERN9, Q9JJS6
      UniProtKB/TrEMBL
      Q05AC0
      Related
      ENSMUSP00000034308.9, ENSMUST00000034308.16
      Conserved Domains (1) summary
      pfam03055
      Location:10519
      RPE65; Retinal pigment epithelial membrane protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      117822590..117860459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248481.3XP_011246783.1  beta,beta-carotene 15,15'-dioxygenase isoform X1

      See identical proteins and their annotated locations for XP_011246783.1

      UniProtKB/TrEMBL
      E9Q321
      Conserved Domains (1) summary
      pfam03055
      Location:11471
      RPE65; Retinal pigment epithelial membrane protein