S100A13 S100 calcium binding protein A13 [Homo sapiens (human)] - Gene

Summary

Official Symbol: S100A13provided by HGNC
Official Full Name: S100 calcium binding protein A13provided by HGNC
Primary source: HGNC:HGNC:10490
See related: Ensembl:ENSG00000189171 MIM:601989; AllianceGenome:HGNC:10490
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Broad expression in heart (RPKM 156.8), fat (RPKM 39.4) and 16 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q21.3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (153618799..153634361, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (152756063..152771625, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (153591275..153606837, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genome-wide analysis of DNA methylation identifies S100A13 as an epigenetic biomarker in individuals with chronic (>/= 30 years) type 2 diabetes without diabetic retinopathy.
Title: Genome-wide analysis of DNA methylation identifies S100A13 as an epigenetic biomarker in individuals with chronic (≥ 30 years) type 2 diabetes without diabetic retinopathy.
An atypical pulmonary fibrosis is associated with co-inheritance of mutations in the calcium binding protein genes S100A3 and S100A13.
Title: An atypical pulmonary fibrosis is associated with co-inheritance of mutations in the calcium binding protein genes S100A3 and S100A13.
These findings unveil a critical role of the non-classical secretory pathway of IL-1alpha in cellular senescence and SASP regulation.
Title: S100A13 promotes senescence-associated secretory phenotype and cellular senescence via modulation of non-classical secretion of IL-1α.
High S100A13 expression is closely associated with high intratumoral angiogenesis and poor prognosis in patients with stage I NSCLC. Immunohistochemical evaluation of S100A13 expression, along with an examination of the perioperative extent of angiolymphatic invasion, has value for predicting prognosis.
Title: Overexpression of S100A13 protein is associated with tumor angiogenesis and poor survival in patients with early-stage non-small cell lung cancer.
This is the first report for the association between HMGA1 and S100A13 expression in the modulation of thyroid cancer growth and invasion.
Title: The association between S100A13 and HMGA1 in the modulation of thyroid cancer proliferation and invasion.
S100A13 interacts with the C2 domain of RAGE.
Title: Interaction of S100A13 with C2 domain of receptor for advanced glycation end products (RAGE).
S100A13 is involved in cutaneous malignant melanoma resistance to DTIC/TMZ.
Title: Proteomics analysis of melanoma metastases: association between S100A13 expression and chemotherapy resistance.
the IL1alpha-S100A13 tetrameric complex is the key complex formed during the non-classical pathway of IL1alpha release
Title: The IL1alpha-S100A13 heterotetrameric complex structure: a component in the non-classical pathway for interleukin 1alpha secretion.
S100A13 promotes the release of FGF-1 protein, but does not affect the transportation of FGF-1 protein in human umbilical vein endothelial cells.
Title: Effect of human S100A13 gene silencing on FGF-1 transportation in human endothelial cells.
S100A13 is expressed in melanocytic lesions when the angiogenic switch occurs and it may cooperate with VEGF-A in supporting the formation of new blood vessels, favoring the shift from radial to vertical tumor growth.
Title: S100A13 is a new angiogenic marker in human melanoma.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH41891 (e-PCR)
- UniSTS:10522

RH91554 (e-PCR)
- UniSTS:91418

RH71309 (e-PCR)
- UniSTS:12624

STS-X58079 (e-PCR)
- UniSTS:51808

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RAGE receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables RAGE receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables copper ion binding	IDA Inferred from Direct Assay more info	PubMed
enables fibroblast growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in mast cell degranulation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-1 alpha production	IDA Inferred from Direct Assay more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: protein S100-A13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024210.2 → NP_001019381.1 protein S100-A13

See identical proteins and their annotated locations for NP_001019381.1

Status: REVIEWED

Source sequence(s)

AL162258, BC000632, CK817939

Consensus CDS

CCDS30874.1

UniProtKB/Swiss-Prot

Q52PI9, Q6FGF8, Q99584

Conserved Domains (1) summary

cd05022
Location:7 → 88

S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...
NM_001024211.2 → NP_001019382.1 protein S100-A13

See identical proteins and their annotated locations for NP_001019382.1

Status: REVIEWED

Source sequence(s)

AL162258, BX470102

Consensus CDS

CCDS30874.1

UniProtKB/Swiss-Prot

Q52PI9, Q6FGF8, Q99584

Related

ENSP00000507299.1, ENST00000476133.6

Conserved Domains (1) summary

cd05022
Location:7 → 88

S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...
NM_001024212.2 → NP_001019383.1 protein S100-A13

See identical proteins and their annotated locations for NP_001019383.1

Status: REVIEWED

Source sequence(s)

BC000632, BM762088

Consensus CDS

CCDS30874.1

UniProtKB/Swiss-Prot

Q52PI9, Q6FGF8, Q99584

Related

ENSP00000376399.1, ENST00000392623.5

Conserved Domains (1) summary

cd05022
Location:7 → 88

S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...
NM_001024213.2 → NP_001019384.1 protein S100-A13

See identical proteins and their annotated locations for NP_001019384.1

Status: REVIEWED

Source sequence(s)

AL162258, BX470102

Consensus CDS

CCDS30874.1

UniProtKB/Swiss-Prot

Q52PI9, Q6FGF8, Q99584

Related

ENSP00000376398.1, ENST00000392622.3

Conserved Domains (1) summary

cd05022
Location:7 → 88

S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...
NM_005979.3 → NP_005970.1 protein S100-A13

See identical proteins and their annotated locations for NP_005970.1

Status: REVIEWED

Source sequence(s)

AL162258, BX470102

Consensus CDS

CCDS30874.1

UniProtKB/Swiss-Prot

Q52PI9, Q6FGF8, Q99584

Related

ENSP00000392767.2, ENST00000440685.7

Conserved Domains (1) summary

cd05022
Location:7 → 88

S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

153618799..153634361 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047427445.1 → XP_047283401.1 protein S100-A13 isoform X2

UniProtKB/Swiss-Prot

Q52PI9, Q6FGF8, Q99584
XM_047427444.1 → XP_047283400.1 protein S100-A13 isoform X2

UniProtKB/Swiss-Prot

Q52PI9, Q6FGF8, Q99584
XM_047427446.1 → XP_047283402.1 protein S100-A13 isoform X2

UniProtKB/Swiss-Prot

Q52PI9, Q6FGF8, Q99584
XM_047427435.1 → XP_047283391.1 protein S100-A13 isoform X2

UniProtKB/Swiss-Prot

Q52PI9, Q6FGF8, Q99584

Related

ENSP00000520623.1, ENST00000497086.6
XM_047427433.1 → XP_047283389.1 protein S100-A13 isoform X2

UniProtKB/Swiss-Prot

Q52PI9, Q6FGF8, Q99584
XM_047427439.1 → XP_047283395.1 protein S100-A13 isoform X2

UniProtKB/Swiss-Prot

Q52PI9, Q6FGF8, Q99584
XM_047427417.1 → XP_047283373.1 protein S100-A13 isoform X2

UniProtKB/Swiss-Prot

Q52PI9, Q6FGF8, Q99584
XM_047427404.1 → XP_047283360.1 protein S100-A13 isoform X2

UniProtKB/Swiss-Prot

Q52PI9, Q6FGF8, Q99584
XM_047427413.1 → XP_047283369.1 protein S100-A13 isoform X2

UniProtKB/Swiss-Prot

Q52PI9, Q6FGF8, Q99584
XM_017002034.3 → XP_016857523.1 protein S100-A13 isoform X2

UniProtKB/Swiss-Prot

Q52PI9, Q6FGF8, Q99584

Related

ENSP00000520622.1, ENST00000484413.6

Conserved Domains (1) summary

cd05022
Location:7 → 88

S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...
XM_047427406.1 → XP_047283362.1 protein S100-A13 isoform X2

UniProtKB/Swiss-Prot

Q52PI9, Q6FGF8, Q99584
XM_017002035.3 → XP_016857524.1 protein S100-A13 isoform X2

UniProtKB/Swiss-Prot

Q52PI9, Q6FGF8, Q99584

Conserved Domains (1) summary

cd05022
Location:7 → 88

S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...
XM_011509862.4 → XP_011508164.1 protein S100-A13 isoform X2

See identical proteins and their annotated locations for XP_011508164.1

UniProtKB/Swiss-Prot

Q52PI9, Q6FGF8, Q99584

Conserved Domains (1) summary

cd05022
Location:7 → 88

S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...
XM_047427408.1 → XP_047283364.1 protein S100-A13 isoform X2

UniProtKB/Swiss-Prot

Q52PI9, Q6FGF8, Q99584
XM_047427407.1 → XP_047283363.1 protein S100-A13 isoform X2

UniProtKB/Swiss-Prot

Q52PI9, Q6FGF8, Q99584
XM_047427409.1 → XP_047283365.1 protein S100-A13 isoform X2

UniProtKB/Swiss-Prot

Q52PI9, Q6FGF8, Q99584
XM_047427401.1 → XP_047283357.1 protein S100-A13 isoform X2

UniProtKB/Swiss-Prot

Q52PI9, Q6FGF8, Q99584
XM_047427410.1 → XP_047283366.1 protein S100-A13 isoform X2

UniProtKB/Swiss-Prot

Q52PI9, Q6FGF8, Q99584
XM_047427419.1 → XP_047283375.1 protein S100-A13 isoform X2

UniProtKB/Swiss-Prot

Q52PI9, Q6FGF8, Q99584
XM_005245434.4 → XP_005245491.1 protein S100-A13 isoform X2

See identical proteins and their annotated locations for XP_005245491.1

UniProtKB/Swiss-Prot

Q52PI9, Q6FGF8, Q99584

Related

ENSP00000520624.1, ENST00000491177.2

Conserved Domains (1) summary

cd05022
Location:7 → 88

S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...
XM_017002036.2 → XP_016857525.1 protein S100-A13 isoform X2

UniProtKB/Swiss-Prot

Q52PI9, Q6FGF8, Q99584

Conserved Domains (1) summary

cd05022
Location:7 → 88

S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...
XM_047427400.1 → XP_047283356.1 protein S100-A13 isoform X1