NAA35 N-alpha-acetyltransferase 35, NatC auxiliary subunit [Homo sapiens (human)] - Gene

Summary

Official Symbol: NAA35provided by HGNC
Official Full Name: N-alpha-acetyltransferase 35, NatC auxiliary subunitprovided by HGNC
Primary source: HGNC:HGNC:24340
See related: Ensembl:ENSG00000135040 MIM:619438; AllianceGenome:HGNC:24340
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EGAP; MAK10; MAK10P; bA379P1.1
Summary: Predicted to enable transferase activity. Involved in negative regulation of apoptotic process. Located in cytosol; nucleoplasm; and plasma membrane. Part of NatC complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in brain (RPKM 7.0), colon (RPKM 6.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9q21.33

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (85941146..86025462)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (98091659..98175989)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (88556061..88640377)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

salivary exosomal GOLM1-NAA35 chimeric RNA (seG-NchiRNA) constitutes an effective candidate noninvasive biomarker for the convenient, reliable assessment of therapeutic response, recurrence, and early detection.
Title: Evaluation of Salivary Exosomal Chimeric GOLM1-NAA35 RNA as a Potential Biomarker in Esophageal Carcinoma.
A cytokine QTL at the NAA35-GOLM1 locus markedly modulated interleukin (IL)-6 production in response to multiple pathogens and was associated with susceptibility to candidemia.
Title: Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi.
Data demonstrate that chimera GOLM1-MAK10 encodes a secreted fusion protein. Mechanistic studies reveal that GOLM1-MAK10 is likely derived from transcription read-through/splicing rather than being generated from a fusion gene.
Title: Aberrant chimeric RNA GOLM1-MAK10 encoding a secreted fusion protein as a molecular signature for human esophageal squamous cell carcinoma.
Human Naa35 (MAK10) is an auxiliary subunit of the human NatC N-terminal acetyltransferase complex. NatC acetylates hydrophobic Met-starting N-termini, and NatC knockdown induces p53-dependent apoptosis.
Title: Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G63197 (e-PCR)
- UniSTS:140171

D9S1649E (e-PCR)
- UniSTS:153768

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in N-terminal peptidyl-methionine acetylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in smooth muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of NatC complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NatC complex	IDA Inferred from Direct Assay more info	PubMed
part_of NatC complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in plasma membrane	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: N-alpha-acetyltransferase 35, NatC auxiliary subunit

Names: MAK10 homolog, amino-acid N-acetyltransferase subunit; corneal wound healing-related protein; embryonic growth-associated protein homolog; protein MAK10 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001321881.2 → NP_001308810.1 N-alpha-acetyltransferase 35, NatC auxiliary subunit

Status: VALIDATED

Source sequence(s)

AK026296, AK292239, AL161447, BC117429

Consensus CDS

CCDS6673.1

UniProtKB/Swiss-Prot

Q5VZE5, Q5VZE6, Q9H631, Q9H703

UniProtKB/TrEMBL

A8K874

Conserved Domains (1) summary

pfam04112
Location:46 → 181

Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase
NM_001321882.2 → NP_001308811.1 N-alpha-acetyltransferase 35, NatC auxiliary subunit

Status: VALIDATED

Source sequence(s)

AL161447, AL161453, AL353743

Consensus CDS

CCDS6673.1

UniProtKB/Swiss-Prot

Q5VZE5, Q5VZE6, Q9H631, Q9H703

UniProtKB/TrEMBL

A8K874

Conserved Domains (1) summary

pfam04112
Location:46 → 181

Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase
NM_024635.4 → NP_078911.3 N-alpha-acetyltransferase 35, NatC auxiliary subunit

See identical proteins and their annotated locations for NP_078911.3

Status: VALIDATED

Source sequence(s)

AL161447, BC117427, CA945233, DB023442

Consensus CDS

CCDS6673.1

UniProtKB/Swiss-Prot

Q5VZE5, Q5VZE6, Q9H631, Q9H703

UniProtKB/TrEMBL

A8K874

Related

ENSP00000354972.5, ENST00000361671.10

Conserved Domains (1) summary

pfam04112
Location:46 → 181

Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000009.12 Reference GRCh38.p14 Primary Assembly

Range

85941146..86025462

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005252127.5 → XP_005252184.1 N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X1

See identical proteins and their annotated locations for XP_005252184.1

UniProtKB/Swiss-Prot

Q5VZE5, Q5VZE6, Q9H631, Q9H703

UniProtKB/TrEMBL

A8K874

Conserved Domains (1) summary

pfam04112
Location:46 → 181

Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase
XM_047423710.1 → XP_047279666.1 N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X2
XM_024447648.2 → XP_024303416.1 N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X3
XM_024447649.2 → XP_024303417.1 N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X4

Alternate T2T-CHM13v2.0

Genomic

NC_060933.1 Alternate T2T-CHM13v2.0

Range

98091659..98175989

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054363503.1 → XP_054219478.1 N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X1

UniProtKB/Swiss-Prot

Q5VZE5, Q5VZE6, Q9H631, Q9H703
XM_054363504.1 → XP_054219479.1 N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X2
XM_054363505.1 → XP_054219480.1 N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X3
XM_054363506.1 → XP_054219481.1 N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_021929.1: Suppressed sequence

Description

NM_021929.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.