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    Stx7 syntaxin 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60466, updated on 2-Nov-2024

    Summary

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    Symbol
    Stx7provided by RGD
    Full Name
    syntaxin 7provided by RGD
    Primary source
    RGD:619747
    See related
    EnsemblRapid:ENSRNOG00000015670 AllianceGenome:RGD:619747
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables SNAP receptor activity and SNARE binding activity. Involved in endosome to lysosome transport and vesicle fusion. Located in late endosome membrane and lysosomal membrane. Part of SNARE complex. Is active in synaptic vesicle membrane. Orthologous to human STX7 (syntaxin 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 292.5), Spleen (RPKM 242.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stx7 in Genome Data Viewer
    Location:
    1p12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (23016330..23056579, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (21197075..21237320, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (22241655..22281850, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene monooxygenase, DBH-like 1 Neighboring gene ribosomal protein L36A, pseudogene 17 Neighboring gene uncharacterized LOC134484971 Neighboring gene uncharacterized LOC108349187 Neighboring gene ribosomal protein S29, pseudogene 21 Neighboring gene trace amine-associated receptor 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Intracellular location of syntaxin 7 in human neutrophils. Xie LX, et al. Immunol Lett, 2010 Apr 8. PMID 20170677
    2. Syntaxin 7, a novel syntaxin member associated with the early endosomal compartment. Wong SH, et al. J Biol Chem, 1998 Jan 2. PMID 9417091
    3. Differential palmitoylation of the endosomal SNAREs syntaxin 7 and syntaxin 8. He Y, et al. J Lipid Res, 2009 Mar. PMID 18980942, Free PMC Article
    4. Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking. Prekeris R, et al. Mol Biol Cell, 1999 Nov. PMID 10564279, Free PMC Article
    5. Syntaxin7 is required for lytic granule release from cytotoxic T lymphocytes. Pattu V, et al. Traffic, 2011 Jul. PMID 21438968

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs
      Title: Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables SNAP receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNARE binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables SNARE binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chloride channel inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chloride channel inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables syntaxin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosome to lysosome transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane fusion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organelle assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organelle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in organelle localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organelle localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of T cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of receptor localization to synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of receptor localization to synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle exocytosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in synaptic vesicle to endosome fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SNARE complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in azurophil granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in azurophil granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in immunological synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in immunological synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in terminal bouton HDA PubMed 
    located_in tertiary granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in tertiary granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    syntaxin-7
    Names
    syntaxin-7-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021869.2 → NP_068641.2  syntaxin-7

      See identical proteins and their annotated locations for NP_068641.2

      Status: PROVISIONAL

      Source sequence(s)
      BC085737
      UniProtKB/Swiss-Prot
      O70257, Q5U337
      UniProtKB/TrEMBL
      A0A0G2K6Y9, A6JUL4
      Related
      ENSRNOP00000021318.4, ENSRNOT00000021318.6
      Conserved Domains (2) summary
      cd15875
      Location:168 → 227
      SNARE_syntaxin7; SNARE motif of syntaxin 7
      pfam14523
      Location:18 → 119
      Syntaxin_2; Syntaxin-like protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      23016330..23056579 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017589644.3 → XP_017445133.1  syntaxin-7 isoform X1

      UniProtKB/Swiss-Prot
      O70257, Q5U337
      UniProtKB/TrEMBL
      A0A0G2K6Y9, A6JUL4
      Conserved Domains (2) summary
      cd15875
      Location:168 → 227
      SNARE_syntaxin7; SNARE motif of syntaxin 7
      pfam14523
      Location:18 → 119
      Syntaxin_2; Syntaxin-like protein

    2. XM_039089032.2 → XP_038944960.1  syntaxin-7 isoform X1

      UniProtKB/Swiss-Prot
      O70257, Q5U337
      UniProtKB/TrEMBL
      A0A0G2K6Y9, A6JUL4
      Conserved Domains (2) summary
      cd15875
      Location:168 → 227
      SNARE_syntaxin7; SNARE motif of syntaxin 7
      pfam14523
      Location:18 → 119
      Syntaxin_2; Syntaxin-like protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70257.4 GenPept UniProtKB/Swiss-Prot:O70257

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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