RAF1 Raf-1 proto-oncogene, serine/threonine kinase [Homo sapiens (human)] - Gene

Summary

Official Symbol: RAF1provided by HGNC
Official Full Name: Raf-1 proto-oncogene, serine/threonine kinaseprovided by HGNC
Primary source: HGNC:HGNC:9829
See related: Ensembl:ENSG00000132155 MIM:164760; AllianceGenome:HGNC:9829
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NS5; CRAF; Raf-1; c-Raf; CMD1NN
Summary: This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in bone marrow (RPKM 34.4), heart (RPKM 32.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3p25.2

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (12583601..12664117, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (12582405..12665632, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (12625100..12705616, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RAF1 gene fusions are recurrent driver events in infantile fibrosarcoma-like mesenchymal tumors.
Title: RAF1 gene fusions are recurrent driver events in infantile fibrosarcoma-like mesenchymal tumors.
Cross-Talking Pathways of Rapidly Accelerated Fibrosarcoma-1 (RAF-1) in Alzheimer's Disease.
Title: Cross-Talking Pathways of Rapidly Accelerated Fibrosarcoma-1 (RAF-1) in Alzheimer's Disease.
Molecular analyses of the C-terminal CRAF variants associated with cardiomyopathy reveal their opposing impacts on the active conformation of the kinase domain.
Title: Molecular analyses of the C-terminal CRAF variants associated with cardiomyopathy reveal their opposing impacts on the active conformation of the kinase domain.
RAF1 mutation leading to hypertrophic cardiomyopathy in a Chinese family with a history of sudden cardiac death: A diagnostic insight into Noonan syndrome.
Title: RAF1 mutation leading to hypertrophic cardiomyopathy in a Chinese family with a history of sudden cardiac death: A diagnostic insight into Noonan syndrome.
PHI-1, an Endogenous Inhibitor Protein for Protein Phosphatase-1 and a Pan-Cancer Marker, Regulates Raf-1 Proteostasis.
Title: PHI-1, an Endogenous Inhibitor Protein for Protein Phosphatase-1 and a Pan-Cancer Marker, Regulates Raf-1 Proteostasis.
Recurrent TRAK1::RAF1 Fusions in pediatric low-grade gliomas.
Title: Recurrent TRAK1::RAF1 Fusions in pediatric low-grade gliomas.
TRIM22 promotes the proliferation of glioblastoma cells by activating MAPK signaling and accelerating the degradation of Raf-1.
Title: TRIM22 promotes the proliferation of glioblastoma cells by activating MAPK signaling and accelerating the degradation of Raf-1.
Molecular and cellular evidence for the impact of a hypertrophic cardiomyopathy-associated RAF1 variant on the structure and function of contractile machinery in bioartificial cardiac tissues.
Title: Molecular and cellular evidence for the impact of a hypertrophic cardiomyopathy-associated RAF1 variant on the structure and function of contractile machinery in bioartificial cardiac tissues.
SHOC2 mediates the drug-resistance of triple-negative breast cancer cells to everolimus.
Title: SHOC2 mediates the drug-resistance of triple-negative breast cancer cells to everolimus.
RAF1 contributes to cell proliferation and STAT3 activation in colorectal cancer independently of microsatellite and KRAS status.
Title: RAF1 contributes to cell proliferation and STAT3 activation in colorectal cancer independently of microsatellite and KRAS status.

Submit: New GeneRIF Correction See all GeneRIFs (287)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Dilated cardiomyopathy 1NN MedGen: C4014656 OMIM: 615916 GeneReviews: Not available	not available
LEOPARD syndrome 2 MedGen: C1969056 OMIM: 611554 GeneReviews: Noonan Syndrome with Multiple Lentigines	not available
Noonan syndrome 5 MedGen: C1969057 OMIM: 611553 GeneReviews: Noonan Syndrome	not available

Copy number response

Description
Copy number response Haploinsufficency No evidence available (Last evaluated 2018-09-13) ClinGen Genome Curation Page Triplosensitivity No evidence available (Last evaluated 2018-09-13) ClinGen Genome Curation Page

EBI GWAS Catalog

Description
Biological, clinical and population relevance of 95 loci for blood lipids. EBI GWAS Catalog EBI GWAS CatalogPubMed
Discovery and refinement of loci associated with lipid levels. EBI GWAS Catalog EBI GWAS CatalogPubMed
Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120-induced release of IL-10 depends on the activation of Raf-1 along with NF-kappaB p65 in immature dentritic cells	PubMed
	env	DC-SIGN-induced signaling by HIV-1 is essential for Raf-1-mediated phosphorylation of p65 NFkappaB at Ser276, which recruits pTEF-b to HIV-1 LTR to phosphorylate RNAPII at Ser2	PubMed
	env	Interaction of gp120 with DC-SIGN activates Raf-1 and phosphorylates Raf-1 at positions Ser338, Tyr340, and Tyr341	PubMed
	env	Binding of HIV-1 gp120 to CD4 molecules results in the association of Lck and Raf-1, which is abolished by preincubation of the virus with soluble CD4	PubMed
Nef	nef	A conserved acidic sequence motif in HIV-1 Nef at positions 174-179 binds to c-Raf1; the interaction of Nef with c-Raf1 leads to a downstream transduction of cell signaling through the c-Raf1-MAP kinase pathway in vivo	PubMed
Tat	tat	HIV-1 Tat activates PRKCQ (PKC-theta) kinase activity, which leads to RELA (NFkB), NRAS, RAF1, MAP2K1 (MEK1), MAP2K2 (MEK2), MAPK3 (ERK1), and MAPK1 (ERK2) activation, in Jurkat T cells that stably express Tat	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G32929 (e-PCR)
- UniSTS:117507

D3S4000 (e-PCR)
- UniSTS:8196

STS-N27641 (e-PCR)
- UniSTS:54060

GDB:181223 (e-PCR)
- UniSTS:155191

G15882 (e-PCR)
- UniSTS:44344

RH118840 (e-PCR)
- UniSTS:138822

GDB:217154 (e-PCR)
- UniSTS:156230

A009W45 (e-PCR)
- UniSTS:64891

D3S2870E (e-PCR)
- UniSTS:81285

RAF1_478 (e-PCR)
- UniSTS:277655

SHGC-57030 (e-PCR)
- UniSTS:24801

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	EXP Inferred from Experiment more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
NOT enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ERBB2-ERBB3 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in Schwann cell development	IEA Inferred from Electronic Annotation more info
involved_in activation of adenylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within_positive_effect apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in death-inducing signaling complex assembly	IEA Inferred from Electronic Annotation more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info
involved_in face development	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin secretion involved in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in intermediate filament cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in myelination	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cysteine-type endopeptidase activity	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotrophin TRK receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of Rho protein signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in regulation of cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of cell motility	TAS Traceable Author Statement more info	PubMed
involved_in response to muscle stretch	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in somatic stem cell population maintenance	IEA Inferred from Electronic Annotation more info
involved_in thymus development	IEA Inferred from Electronic Annotation more info
involved_in thyroid gland development	IEA Inferred from Electronic Annotation more info
involved_in type B pancreatic cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in type II interferon-mediated signaling pathway	TAS Traceable Author Statement more info
involved_in wound healing	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IPI Inferred from Physical Interaction more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in mitochondrial outer membrane	TAS Traceable Author Statement more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
colocalizes_with plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in pseudopodium	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RAF proto-oncogene serine/threonine-protein kinase

Names: C-Raf proto-oncogene, serine/threonine kinase; Oncogene RAF1; proto-oncogene c-RAF; raf proto-oncogene serine/threonine protein kinase; v-raf-1 murine leukemia viral oncogene homolog 1; v-raf-1 murine leukemia viral oncogene-like protein 1

NP_001341618.1

EC 2.7.11.1

NP_001341619.1

EC 2.7.11.1

NP_001341620.1

EC 2.7.11.1

NP_001341621.1

EC 2.7.11.1

NP_001341622.1

EC 2.7.11.1

NP_001341623.1

EC 2.7.11.1

NP_001341624.1

EC 2.7.11.1

NP_002871.1

EC 2.7.11.1

XP_011532276.1

EC 2.7.11.1

XP_016862455.1

EC 2.7.11.1

XP_047304605.1

EC 2.7.11.1

XP_047304606.1

EC 2.7.11.1

XP_047304607.1

EC 2.7.11.1

XP_054203389.1

EC 2.7.11.1

XP_054203390.1

EC 2.7.11.1

XP_054203391.1

EC 2.7.11.1

XP_054203392.1

EC 2.7.11.1

XP_054203393.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007467.1 RefSeqGene

Range

4979..85579

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_413

mRNA and Protein(s)

NM_001354689.3 → NP_001341618.1 RAF proto-oncogene serine/threonine-protein kinase isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

AC018500, AC026170

Consensus CDS

CCDS87047.1

UniProtKB/TrEMBL

A0A0S2Z559, A0A8I5KSV6

Related

ENSP00000401888.2, ENST00000442415.7

Conserved Domains (3) summary

cd01816
Location:57 → 131

Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases

cd14149
Location:356 → 638

STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase

pfam00130
Location:139 → 187

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
NM_001354690.3 → NP_001341619.1 RAF proto-oncogene serine/threonine-protein kinase isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (3), as well as variant 2, encodes isoform b.

Source sequence(s)

AC018500, AC026170

Consensus CDS

CCDS2612.1

UniProtKB/Swiss-Prot

B0LPH8, B2R5N3, P04049, Q15278, Q9UC20

UniProtKB/TrEMBL

A0A024R2G5, A0A8I5KSV6, L7RRS6

Related

ENSP00000508763.1, ENST00000691899.1

Conserved Domains (3) summary

cd14149
Location:336 → 618

STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase

cd17135
Location:55 → 131

RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF

cd20870
Location:136 → 187

C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins
NM_001354691.3 → NP_001341620.1 RAF proto-oncogene serine/threonine-protein kinase isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (4), as well as variant 5, encodes isoform c.

Source sequence(s)

AC018500, AC026170

UniProtKB/TrEMBL

A0A8I5KSB0, B4E0X2

Conserved Domains (2) summary

cd14149
Location:255 → 537

STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase

pfam00130
Location:58 → 103

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
NM_001354692.3 → NP_001341621.1 RAF proto-oncogene serine/threonine-protein kinase isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (5), as well as variant 4, encodes isoform c.

Source sequence(s)

AC018500, AC026170

UniProtKB/TrEMBL

A0A8I5KSB0, B4E0X2

Conserved Domains (2) summary

cd14149
Location:255 → 537

STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase

pfam00130
Location:58 → 103

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
NM_001354693.3 → NP_001341622.1 RAF proto-oncogene serine/threonine-protein kinase isoform d

Status: REVIEWED

Source sequence(s)

AC018500, AC026170

Consensus CDS

CCDS93217.1

UniProtKB/TrEMBL

A0A0S2Z4L5, A0A8I5KQV4, A0A8I5KTA5

Related

ENSP00000509612.1, ENST00000688543.1

Conserved Domains (3) summary

cd14149
Location:303 → 585

STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase

cd17135
Location:55 → 131

RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF

cd20870
Location:136 → 187

C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins
NM_001354694.3 → NP_001341623.1 RAF proto-oncogene serine/threonine-protein kinase isoform e

Status: REVIEWED

Source sequence(s)

AC018500, AC026170

UniProtKB/TrEMBL

A0A8I5KSB0

Conserved Domains (2) summary

cd14149
Location:275 → 557

STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase

pfam00130
Location:58 → 106

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
NM_001354695.3 → NP_001341624.1 RAF proto-oncogene serine/threonine-protein kinase isoform f

Status: REVIEWED

Source sequence(s)

AC018500, AC026170

UniProtKB/TrEMBL

A0A8I5KSB0

Conserved Domains (2) summary

cd14149
Location:222 → 504

STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase

pfam00130
Location:58 → 103

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
NM_002880.4 → NP_002871.1 RAF proto-oncogene serine/threonine-protein kinase isoform b

See identical proteins and their annotated locations for NP_002871.1

Status: REVIEWED

Description

Transcript Variant: This variant (2), as well as variant 3, encodes isoform b.

Source sequence(s)

BC018119, BU683389, DC342671

Consensus CDS

CCDS2612.1

UniProtKB/Swiss-Prot

B0LPH8, B2R5N3, P04049, Q15278, Q9UC20

UniProtKB/TrEMBL

A0A024R2G5, A0A8I5KSV6, L7RRS6

Related

ENSP00000251849.4, ENST00000251849.9

Conserved Domains (3) summary

cd14149
Location:336 → 618

STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase

cd17135
Location:55 → 131

RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF

cd20870
Location:136 → 187

C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

RNA

NR_148940.3 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC018500, AC026170

Related

ENST00000685738.1
NR_148941.3 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC018500, AC026170

Related

ENST00000689914.1
NR_148942.3 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC018500, AC026170

Related

ENST00000691724.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

12583601..12664117 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047448651.1 → XP_047304607.1 RAF proto-oncogene serine/threonine-protein kinase isoform X2

UniProtKB/TrEMBL

A0A0S2Z4L5

Related

ENSP00000509669.1, ENST00000692093.1
XM_011533974.3 → XP_011532276.1 RAF proto-oncogene serine/threonine-protein kinase isoform X1

See identical proteins and their annotated locations for XP_011532276.1

UniProtKB/Swiss-Prot

B0LPH8, B2R5N3, P04049, Q15278, Q9UC20

UniProtKB/TrEMBL

A0A024R2G5, A0A8I5KSV6, L7RRS6

Conserved Domains (3) summary

cd14149
Location:336 → 618

STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase

cd17135
Location:55 → 131

RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF

cd20870
Location:136 → 187

C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins
XM_047448649.1 → XP_047304605.1 RAF proto-oncogene serine/threonine-protein kinase isoform X1

UniProtKB/Swiss-Prot

B0LPH8, B2R5N3, P04049, Q15278, Q9UC20

UniProtKB/TrEMBL

A0A024R2G5, L7RRS6

Related

ENSP00000509968.1, ENST00000685653.1
XM_047448650.1 → XP_047304606.1 RAF proto-oncogene serine/threonine-protein kinase isoform X1

UniProtKB/Swiss-Prot

B0LPH8, B2R5N3, P04049, Q15278, Q9UC20

UniProtKB/TrEMBL

A0A024R2G5, L7RRS6
XM_017006966.1 → XP_016862455.1 RAF proto-oncogene serine/threonine-protein kinase isoform X2

UniProtKB/TrEMBL

A0A0S2Z4L5, A0A8I5KQV4, A0A8I5KTA5

Conserved Domains (3) summary

cd14149
Location:303 → 585

STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase

cd17135
Location:55 → 131

RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF

cd20870
Location:136 → 187

C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

Alternate T2T-CHM13v2.0

Genomic

NC_060927.1 Alternate T2T-CHM13v2.0

Range

12582405..12665632 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054347417.1 → XP_054203392.1 RAF proto-oncogene serine/threonine-protein kinase isoform X2

UniProtKB/TrEMBL

A0A0S2Z4L5
XM_054347414.1 → XP_054203389.1 RAF proto-oncogene serine/threonine-protein kinase isoform X1

UniProtKB/Swiss-Prot

B0LPH8, B2R5N3, P04049, Q15278, Q9UC20

UniProtKB/TrEMBL

A0A024R2G5, L7RRS6
XM_054347415.1 → XP_054203390.1 RAF proto-oncogene serine/threonine-protein kinase isoform X1

UniProtKB/Swiss-Prot

B0LPH8, B2R5N3, P04049, Q15278, Q9UC20

UniProtKB/TrEMBL

A0A024R2G5, L7RRS6
XM_054347416.1 → XP_054203391.1 RAF proto-oncogene serine/threonine-protein kinase isoform X1

UniProtKB/Swiss-Prot

B0LPH8, B2R5N3, P04049, Q15278, Q9UC20

UniProtKB/TrEMBL

A0A024R2G5, L7RRS6
XM_054347418.1 → XP_054203393.1 RAF proto-oncogene serine/threonine-protein kinase isoform X2

UniProtKB/TrEMBL

A0A0S2Z4L5