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    ska3 spindle and kinetochore associated complex subunit 3 [ Danio rerio (zebrafish) ]

    Gene ID: 570479, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ska3provided by ZNC
    Official Full Name
    spindle and kinetochore associated complex subunit 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2997
    See related
    Ensembl:ENSDARG00000069917 AllianceGenome:ZFIN:ZDB-GENE-030131-2997
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc23d11; wu:fc23d11; si:rp71-68n21.13
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in attachment of mitotic spindle microtubules to kinetochore and regulation of microtubule polymerization or depolymerization. Predicted to act upstream of or within cell division. Predicted to be located in meiotic spindle and mitotic spindle. Predicted to be part of outer kinetochore. Predicted to be active in kinetochore and spindle microtubule. Orthologous to human SKA3 (spindle and kinetochore associated complex subunit 3). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ska3 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (21259820..21265611)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (21448951..21454742)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase copper chaperone COX17 Neighboring gene hyperpolarization activated cyclic nucleotide-gated potassium channel 5 Neighboring gene potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2-like Neighboring gene uncharacterized LOC101884374 Neighboring gene Sin3A-associated protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Online automated in vivo zebrafish phosphoproteomics: from large-scale analysis down to a single embryo. Lemeer S, et al. J Proteome Res, 2008 Apr. PMID 18307296
    2. Insm1a-mediated gene repression is essential for the formation and differentiation of Müller glia-derived progenitors in the injured retina. Ramachandran R, et al. Nat Cell Biol, 2012 Oct. PMID 23000964, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in attachment of mitotic spindle microtubules to kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic metaphase chromosome alignment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic sister chromatid segregation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of microtubule polymerization or depolymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in meiotic spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of outer kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of outer kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of outer kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    SKA complex subunit 3; spindle and kinetochore-associated protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001202437.1 → NP_001189366.1  SKA complex subunit 3

      See identical proteins and their annotated locations for NP_001189366.1

      Status: VALIDATED

      Source sequence(s)
      BX511129, EH478847, EH501612, EH578587, EH595954
      UniProtKB/Swiss-Prot
      Q58EL7
      UniProtKB/TrEMBL
      A0A8M1P1R9, F1R1H3
      Related
      ENSDARP00000116579.1, ENSDART00000137024.3
      Conserved Domains (1) summary
      cd12957
      Location:3 → 103
      SKA3_N; Spindle and kinetochore-associated protein 3, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      21259820..21265611
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167590.5 → XP_005167647.1  spindle and kinetochore-associated protein 3 isoform X1

      See identical proteins and their annotated locations for XP_005167647.1

      UniProtKB/Swiss-Prot
      Q58EL7
      UniProtKB/TrEMBL
      A0A8M1P1R9, F1R1H3
      Conserved Domains (1) summary
      cd12957
      Location:3 → 103
      SKA3_N; Spindle and kinetochore-associated protein 3, N-terminal domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394749.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      129347..135369
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q58EL7.2 GenPept UniProtKB/Swiss-Prot:Q58EL7

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