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    fscn1b fascin actin-bundling protein 1b [ Danio rerio (zebrafish) ]

    Gene ID: 570314, updated on 2-Nov-2024

    Summary

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    Official Symbol
    fscn1bprovided by ZNC
    Official Full Name
    fascin actin-bundling protein 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-120507-1
    See related
    Ensembl:ENSDARG00000037747 AllianceGenome:ZFIN:ZDB-GENE-120507-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-160d14.1
    Summary
    Predicted to enable actin filament binding activity and protein-macromolecule adaptor activity. Predicted to act upstream of or within actin filament organization. Predicted to be located in cytoplasm and cytoskeleton. Is expressed in brain and telencephalon. Orthologous to human FSCN1 (fascin actin-bundling protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See fscn1b in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (8662489..8670489)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (7978350..7984566)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene actin, beta 1 Neighboring gene uncharacterized LOC137495411 Neighboring gene ATP-binding cassette, sub-family G (WHITE), member 2b Neighboring gene HUWE1 associated protein modifying stress responses b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Fascin1-dependent Filopodia are required for directional migration of a subset of neural crest cells. Boer EF, et al. PLoS Genet, 2015 Jan. PMID 25607881, Free PMC Article
    2. Fscn1 is required for the trafficking of TGF-β family type I receptors during endoderm formation. Liu Z, et al. Nat Commun, 2016 Aug 22. PMID 27545838, Free PMC Article
    3. Characterization of paralogous uncx transcription factor encoding genes in zebrafish. Nittoli V, et al. Gene X, 2019 Jun. PMID 31193955, Free PMC Article
    4. A new evolutionary model for the vertebrate actin family including two novel groups. Witjes L, et al. Mol Phylogenet Evol, 2019 Dec. PMID 31560986
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fascin; fascin actin-bundling protein 1b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      8662489..8670489
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005170877.5 → XP_005170934.1  fascin

      UniProtKB/TrEMBL
      A0A0A0MPL5, A0A8M9PPJ3
      Related
      ENSDARP00000094422.4, ENSDART00000054989.7
      Conserved Domains (2) summary
      cd00257
      Location:382 → 494
      Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...
      pfam06268
      Location:268 → 377
      Fascin; Fascin domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394460.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      84034..90087
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021471104.2 → XP_021326779.1  fascin

      UniProtKB/TrEMBL
      A0A0A0MPL5, A0A8M9PPJ3
      Conserved Domains (2) summary
      cd00257
      Location:382 → 494
      Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...
      pfam06268
      Location:268 → 377
      Fascin; Fascin domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001082869.2: Suppressed sequence

      Description
      NM_001082869.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

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