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    casp3b caspase 3, apoptosis-related cysteine peptidase b [ Danio rerio (zebrafish) ]

    Gene ID: 566604, updated on 14-Nov-2024

    Summary

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    Official Symbol
    casp3bprovided by ZNC
    Official Full Name
    caspase 3, apoptosis-related cysteine peptidase bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070607-1
    See related
    Ensembl:ENSDARG00000055045 AllianceGenome:ZFIN:ZDB-GENE-070607-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    casp3l
    Summary
    Enables protein homodimerization activity. Predicted to be involved in several processes, including erythrocyte differentiation; keratinocyte differentiation; and positive regulation of neuron apoptotic process. Predicted to be part of death-inducing signaling complex. Predicted to be active in cytoplasm. Is expressed in female organism; intestine; muscle cell; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in Parkinson's disease; colon cancer; lung non-small cell carcinoma; and stomach cancer. Orthologous to human CASP3 (caspase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See casp3b in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (4129369..4151254, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (4022662..4054024, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 6 Neighboring gene interferon regulatory factor 2b Neighboring gene dehydrogenase/reductase (SDR family) member 13 like 1 Neighboring gene centromere protein U

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Phage display and structural studies reveal plasticity in substrate specificity of caspase-3a from zebrafish. Tucker MB, et al. Protein Sci, 2016 Nov. PMID 27577093, Free PMC Article
    2. Remodeling hydrogen bond interactions results in relaxed specificity of Caspase-3. Yao L, et al. Biosci Rep, 2021 Jan 29. PMID 33448281, Free PMC Article
    3. Comparing the folding landscapes of evolutionarily divergent procaspase-3. Yao L, et al. Biosci Rep, 2022 Jun 30. PMID 35670809, Free PMC Article
    4. Silver nanoparticles induce oocyte maturation in zebrafish (Danio rerio). Chen SX, et al. Chemosphere, 2017 Mar. PMID 27974271, Free PMC Article
    5. Anisomycin induces hair cell death and blocks supporting cell proliferation in zebrafish lateral line neuromast. Yuan X, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2021 Sep. PMID 33887477

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in erythrocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in execution phase of apoptosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in keratinocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of death-inducing signaling complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    caspase-3b
    Names
    caspase 3, apoptosis-related cysteine protease b
    caspase 3, apoptosis-related cysteine protease, like
    NP_001041531.2
    XP_005173133.1
    XP_068069330.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048066.2 → NP_001041531.2  caspase-3b

      Status: VALIDATED

      Source sequence(s)
      FP102891
      UniProtKB/TrEMBL
      A0A8M2BKT2, F1Q7K7
      Related
      ENSDARP00000071815.4, ENSDART00000077348.6
      Conserved Domains (1) summary
      cd00032
      Location:47 → 284
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      4129369..4151254 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005173076.5 → XP_005173133.1  caspase-3b isoform X1

      See identical proteins and their annotated locations for XP_005173133.1

      UniProtKB/TrEMBL
      A0A8M2BKT2, F1Q7K7
      Conserved Domains (1) summary
      cd00032
      Location:47 → 284
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

    2. XM_068213229.1 → XP_068069330.1  caspase-3b isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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