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    pde4ba phosphodiesterase 4B, cAMP-specific a [ Danio rerio (zebrafish) ]

    Gene ID: 565706, updated on 2-Nov-2024

    Summary

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    Official Symbol
    pde4baprovided by ZNC
    Official Full Name
    phosphodiesterase 4B, cAMP-specific aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9570
    See related
    Ensembl:ENSDARG00000032868 AllianceGenome:ZFIN:ZDB-GENE-030131-9570
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    pde4b; fj87g04; wu:fj87g04
    Summary
    Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; and transmembrane transporter binding activity. Predicted to be involved in cAMP-mediated signaling. Predicted to act upstream of or within signal transduction. Predicted to be active in cytosol; nucleus; and perinuclear region of cytoplasm. Is expressed in oocyte and oocyte stage V. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human PDE4B (phosphodiesterase 4B). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pde4ba in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (30851547..31182940, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (30864633..31160268, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene insulin-like 5a Neighboring gene SH3GL interacting endocytic adaptor 1a Neighboring gene leptin receptor Neighboring gene uncharacterized LOC137490216

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Role of natriuretic peptide receptor 2-mediated signaling in meiotic arrest of zebrafish oocytes and its estrogen regulation through G protein-coupled estrogen receptor (Gper). Pang Y, et al. Gen Comp Endocrinol, 2018 Sep 1. PMID 29574150
    2. Heterogeneous T cell motility behaviors emerge from a coupling between speed and turning in vivo. Jerison ER, et al. Elife, 2020 May 19. PMID 32427565, Free PMC Article
    3. RES complex is associated with intron definition and required for zebrafish early embryogenesis. Fernandez JP, et al. PLoS Genet, 2018 Jul. PMID 29969449, Free PMC Article
    4. Evolution of Class I cytokine receptors. Liongue C, et al. BMC Evol Biol, 2007 Jul 18. PMID 17640376, Free PMC Article
    5. Protein kinase C family evolution in jawed vertebrates. Garcia-Concejo A, et al. Dev Biol, 2021 Nov. PMID 34329618

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cAMP catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cAMP-specific 3',5'-cyclic phosphodiesterase 4B; 3',5'-cyclic-AMP phosphodiesterase 4B
    Names
    phosphodiesterase E4 dunce homolog
    XP_005165938.1
    XP_005165939.1
    XP_021327460.1
    XP_021327461.1
    XP_021327462.1
    XP_021332832.1
    XP_021332833.1
    XP_068074426.1
    XP_068074427.1
    XP_068074428.1
    XP_068074429.1
    XP_068074430.1
    XP_068078093.1
    XP_068078094.1
    XP_068078095.1
    XP_068078096.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      30851547..31182940 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068221992.1 → XP_068078093.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform X1

    2. XM_021477157.2 → XP_021332832.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform X2

      UniProtKB/TrEMBL
      A0A8M9PMW2
      Conserved Domains (1) summary
      pfam00233
      Location:404 → 641
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    3. XM_068221993.1 → XP_068078094.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform X2

    4. XM_021477158.2 → XP_021332833.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform X3

      UniProtKB/TrEMBL
      A0A8M9Q0L5
      Conserved Domains (1) summary
      pfam00233
      Location:383 → 620
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    5. XM_068221994.1 → XP_068078095.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform X4

      Related
      ENSDARP00000030741.9, ENSDART00000028612.9

    6. XM_068221995.1 → XP_068078096.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform X5

      Related
      ENSDARP00000129333.1, ENSDART00000154523.3

    7. XM_005165881.4 → XP_005165938.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform X6

      UniProtKB/TrEMBL
      A0A8M9PYP3
      Conserved Domains (1) summary
      pfam00233
      Location:177 → 414
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    8. XM_005165882.5 → XP_005165939.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform X7

      UniProtKB/TrEMBL
      A0A8M2BD66
      Related
      ENSDARP00000127495.1, ENSDART00000156235.3
      Conserved Domains (1) summary
      pfam00233
      Location:171 → 408
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394650.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      29871..367078 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068218325.1 → XP_068074426.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform X1

    2. XM_068218326.1 → XP_068074427.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform X2

    3. XM_068218329.1 → XP_068074430.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform X2

    4. XM_021471785.2 → XP_021327460.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform X3

      UniProtKB/TrEMBL
      A0A8M9Q0L5
      Conserved Domains (1) summary
      pfam00233
      Location:383 → 620
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    5. XM_068218327.1 → XP_068074428.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform X4

    6. XM_068218328.1 → XP_068074429.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform X5

    7. XM_021471786.2 → XP_021327461.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform X6

      UniProtKB/TrEMBL
      A0A8M9PYP3
      Conserved Domains (1) summary
      pfam00233
      Location:177 → 414
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    8. XM_021471787.2 → XP_021327462.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform X7

      UniProtKB/TrEMBL
      A0A8M2BD66
      Conserved Domains (1) summary
      pfam00233
      Location:171 → 408
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    Nucleotide Protein Strain
    Heading Accession and Version

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