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    eef1da eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein) [ Danio rerio (zebrafish) ]

    Gene ID: 565501, updated on 2-Nov-2024

    Summary

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    Official Symbol
    eef1daprovided by ZNC
    Official Full Name
    eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2740
    See related
    Ensembl:ENSDARG00000102291 AllianceGenome:ZFIN:ZDB-GENE-040426-2740
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    eef1d; zgc:66406
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in translational elongation. Predicted to act upstream of or within translation. Predicted to be part of eukaryotic translation elongation factor 1 complex. Predicted to be active in cytosol. Orthologous to human EEF1D (eukaryotic translation elongation factor 1 delta). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See eef1da in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (50999704..51031260)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (51265476..51297040)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene transfer RNA leucine (anticodon UAA) Neighboring gene transfer RNA leucine (anticodon UAA) Neighboring gene finTRIM family, member 87 Neighboring gene finTRIM family, member 67

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55300, MGC111981

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation elongation factor 1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein)
    Names
    elongation factor-1, delta, a
    guanine nucleotide exchange protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177453.2 → NP_001170924.2  eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein)

      Status: VALIDATED

      Source sequence(s)
      EB797127, EG579283, EH475402
      UniProtKB/TrEMBL
      A0A0R4IA30, A0A8M1NUJ5
      Related
      ENSDARP00000130232.1, ENSDART00000158064.2
      Conserved Domains (2) summary
      cd00292
      Location:157 → 245
      EF1B; Elongation factor 1 beta (EF1B) guanine nucleotide exchange domain. EF1B catalyzes the exchange of GDP bound to the G-protein, EF1A, for GTP, an important step in the elongation cycle of the protein biosynthesis. EF1A binds to and delivers the aminoacyl ...
      pfam10587
      Location:125 → 150
      EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      50999704..51031260
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017358747.3 → XP_017214236.1  eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein) isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z1P2

    2. XM_021480943.2 → XP_021336618.1  eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein) isoform X2

      UniProtKB/TrEMBL
      A0A8M9QAS6
      Conserved Domains (2) summary
      pfam00736
      Location:358 → 441
      EF1_GNE; EF-1 guanine nucleotide exchange domain
      pfam10587
      Location:321 → 346
      EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

    3. XM_021480949.2 → XP_021336624.1  eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein) isoform X4

      UniProtKB/TrEMBL
      A0A8M9QG85
      Conserved Domains (2) summary
      pfam00736
      Location:334 → 417
      EF1_GNE; EF-1 guanine nucleotide exchange domain
      pfam10587
      Location:297 → 322
      EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

    4. XM_068224637.1 → XP_068080738.1  eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein) isoform X3

    5. XM_005163594.4 → XP_005163651.1  eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein) isoform X5

      UniProtKB/TrEMBL
      A0A8M2BAS2
      Related
      ENSDARP00000134060.1, ENSDART00000165746.2
      Conserved Domains (2) summary
      cd00292
      Location:203 → 291
      EF1B; Elongation factor 1 beta (EF1B) guanine nucleotide exchange domain. EF1B catalyzes the exchange of GDP bound to the G-protein, EF1A, for GTP, an important step in the elongation cycle of the protein biosynthesis. EF1A binds to and delivers the aminoacyl ...
      pfam10587
      Location:171 → 196
      EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

    6. XM_005163595.4 → XP_005163652.1  eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein) isoform X6

      UniProtKB/TrEMBL
      A0A8M2BAX4
      Related
      ENSDARP00000139875.1, ENSDART00000164775.2
      Conserved Domains (3) summary
      cd00292
      Location:181 → 269
      EF1B; Elongation factor 1 beta (EF1B) guanine nucleotide exchange domain. EF1B catalyzes the exchange of GDP bound to the G-protein, EF1A, for GTP, an important step in the elongation cycle of the protein biosynthesis. EF1A binds to and delivers the aminoacyl ...
      pfam10587
      Location:149 → 174
      EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
      cl01287
      Location:91 → 205
      AE_Prim_S_like; AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis ...
    Nucleotide Protein Strain
    Heading Accession and Version

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