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    rtkna rhotekin a [ Danio rerio (zebrafish) ]

    Gene ID: 564545, updated on 12-Sep-2024

    Summary

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    Official Symbol
    rtknaprovided by ZNC
    Official Full Name
    rhotekin aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060531-142
    See related
    Ensembl:ENSDARG00000031345 AllianceGenome:ZFIN:ZDB-GENE-060531-142
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-40c11.1
    Summary
    Predicted to be involved in actomyosin contractile ring assembly; mitotic cytokinesis; and septin ring organization. Predicted to act upstream of or within Rho protein signal transduction and septin cytoskeleton organization. Predicted to be active in actomyosin contractile ring. Orthologous to human RTKN (rhotekin). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See rtkna in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (43612031..43760454, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (43015950..43160354, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene Rho related BTB domain containing 4 Neighboring gene si:dkey-40c11.2 Neighboring gene nitric oxide synthase 2a, inducible Neighboring gene survival of motor neuron 1, telomeric

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in actomyosin contractile ring assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in septin ring organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actomyosin contractile ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rhotekin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126415.1 → NP_001119887.1  rhotekin

      Status: PROVISIONAL

      Source sequence(s)
      BX784028
      UniProtKB/TrEMBL
      A0A8N1TR38, A2BI20
      Related
      ENSDARP00000069502.5, ENSDART00000075017.6
      Conserved Domains (5) summary
      smart00742
      Location:7 → 62
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:285 → 394
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam00169
      Location:287 → 386
      PH; PH domain
      pfam08174
      Location:88 → 246
      Anillin; Cell division protein anillin
      pfam10630
      Location:471 → 498
      DUF2476; Protein of unknown function (DUF2476)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      43612031..43760454 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165339.5 → XP_005165396.1  rhotekin isoform X1

      UniProtKB/TrEMBL
      A0A8M2BCU1
      Conserved Domains (5) summary
      smart00742
      Location:37 → 91
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:314 → 423
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam00169
      Location:316 → 415
      PH; PH domain
      pfam08174
      Location:117 → 275
      Anillin; Cell division protein anillin
      pfam10630
      Location:500 → 527
      DUF2476; Protein of unknown function (DUF2476)

    2. XM_005165340.5 → XP_005165397.1  rhotekin isoform X2

      UniProtKB/TrEMBL
      A0A8M2BCM4
      Conserved Domains (5) summary
      smart00742
      Location:31 → 86
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:309 → 418
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam00169
      Location:311 → 410
      PH; PH domain
      pfam08174
      Location:112 → 270
      Anillin; Cell division protein anillin
      pfam10630
      Location:495 → 522
      DUF2476; Protein of unknown function (DUF2476)

    3. XM_005165341.5 → XP_005165398.1  rhotekin isoform X3

      UniProtKB/TrEMBL
      A0A8M2BCN7
      Conserved Domains (4) summary
      smart00742
      Location:37 → 91
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:314 → 423
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam00169
      Location:316 → 415
      PH; PH domain
      pfam08174
      Location:117 → 275
      Anillin; Cell division protein anillin

    4. XM_068221247.1 → XP_068077348.1  rhotekin isoform X4

    Nucleotide Protein
    Heading Accession and Version

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