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    B4galt4 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 4 [ Mus musculus (house mouse) ]

    Gene ID: 56375, updated on 28-Oct-2024

    Summary

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    Official Symbol
    B4galt4provided by MGI
    Official Full Name
    UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 4provided by MGI
    Primary source
    MGI:MGI:1928387
    See related
    Ensembl:ENSMUSG00000022793 AllianceGenome:MGI:1928387
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    b4Gal-T4; B4galt-IV; beta4Gal-T4; beta4GalT-IV; 9130402O08Rik
    Summary
    Predicted to enable N-acetyllactosamine synthase activity. Predicted to be involved in glycosylation; keratan sulfate biosynthetic process; and lactosylceramide biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Is expressed in gland and thyroid gland. Orthologous to human B4GALT4 (beta-1,4-galactosyltransferase 4). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 9.5), colon adult (RPKM 7.0) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See B4galt4 in Genome Data Viewer
    Location:
    16 26.87 cM; 16 B4
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (38562600..38589416)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (38742220..38769054)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 31 Neighboring gene predicted gene, 36482 Neighboring gene anaphase promoting complex subunit 10 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:38713123-38713232 Neighboring gene STARR-positive B cell enhancer ABC_E11612 Neighboring gene RNA binding motif protein 39 pseudogene Neighboring gene uroplakin 1B Neighboring gene testis expressed 55

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Beta-1,4-galactosyltransferase-3 deficiency suppresses the growth of immunogenic tumors in mice. Wei H, et al. Front Immunol, 2023. PMID 37901252, Free PMC Article
    2. The expanding beta 4-galactosyltransferase gene family: messages from the databanks. Lo NW, et al. Glycobiology, 1998 May. PMID 9597550
    3. Developmental changes of glycosphingolipids and expression of glycogenes in mouse brains. Ngamukote S, et al. J Neurochem, 2007 Dec. PMID 17883393
    4. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetyllactosamine synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables N-acetyllactosamine synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables UDP-galactosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables UDP-galactosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables galactosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in keratan sulfate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in keratan sulfate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lactosylceramide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lactosylceramide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    beta-1,4-galactosyltransferase 4
    Names
    N-acetyllactosamine synthase
    UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4
    UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4
    beta-1,4-GalTase 4
    beta-1,4-galactosyltransferase IV
    beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase
    lactotriaosylceramide beta-1,4-galactosyltransferase
    nal synthase
    NP_001272722.1
    NP_062778.2
    XP_006522462.1
    XP_011244279.1
    XP_036015930.1
    XP_036015931.1
    XP_036015932.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285793.1 → NP_001272722.1  beta-1,4-galactosyltransferase 4

      See identical proteins and their annotated locations for NP_001272722.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK053603, CT009576
      Consensus CDS
      CCDS28173.1
      UniProtKB/Swiss-Prot
      Q8BR54, Q9JJ04, Q9QY12
      Related
      ENSMUSP00000110360.2, ENSMUST00000114712.8
      Conserved Domains (1) summary
      cd00899
      Location:122 → 339
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

    2. NM_019804.4 → NP_062778.2  beta-1,4-galactosyltransferase 4

      See identical proteins and their annotated locations for NP_062778.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK050005, BY283636, CT009576
      Consensus CDS
      CCDS28173.1
      UniProtKB/Swiss-Prot
      Q8BR54, Q9JJ04, Q9QY12
      Related
      ENSMUSP00000023482.7, ENSMUST00000023482.13
      Conserved Domains (1) summary
      cd00899
      Location:122 → 339
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

    RNA

    1. NR_152434.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      CT009576
      Related
      ENSMUST00000154902.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      38562600..38589416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160039.1 → XP_036015932.1  beta-1,4-galactosyltransferase 4 isoform X2

      Conserved Domains (1) summary
      cl11394
      Location:122 → 298
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    2. XM_036160038.1 → XP_036015931.1  beta-1,4-galactosyltransferase 4 isoform X2

      Conserved Domains (1) summary
      cl11394
      Location:122 → 298
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    3. XM_006522399.5 → XP_006522462.1  beta-1,4-galactosyltransferase 4 isoform X3

      See identical proteins and their annotated locations for XP_006522462.1

      UniProtKB/Swiss-Prot
      Q8BR54, Q9JJ04, Q9QY12
      Conserved Domains (1) summary
      cd00899
      Location:122 → 339
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

    4. XM_011245977.3 → XP_011244279.1  beta-1,4-galactosyltransferase 4 isoform X1

      See identical proteins and their annotated locations for XP_011244279.1

      Conserved Domains (1) summary
      cd00899
      Location:186 → 403
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

    5. XM_036160037.1 → XP_036015930.1  beta-1,4-galactosyltransferase 4 isoform X2

      Conserved Domains (1) summary
      cl11394
      Location:122 → 298
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    RNA

    1. XR_003951806.2 RNA Sequence

    2. XR_003951807.2 RNA Sequence

    3. XR_875837.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JJ04.1 GenPept UniProtKB/Swiss-Prot:Q9JJ04

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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