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    Timm22 translocase of inner mitochondrial membrane 22 [ Mus musculus (house mouse) ]

    Gene ID: 56322, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Timm22provided by MGI
    Official Full Name
    translocase of inner mitochondrial membrane 22provided by MGI
    Primary source
    MGI:MGI:1929742
    See related
    Ensembl:ENSMUSG00000020843 AllianceGenome:MGI:1929742
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tim22
    Summary
    Predicted to enable mitochondrion targeting sequence binding activity and protein transmembrane transporter activity. Predicted to be involved in protein insertion into mitochondrial inner membrane. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; cardiovascular system; egg cylinder; and genitourinary system. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 43. Orthologous to human TIMM22 (translocase of inner mitochondrial membrane 22). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 6.6), CNS E11.5 (RPKM 6.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Timm22 in Genome Data Viewer
    Location:
    11 B5; 11 45.92 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (76297751..76307139)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (76406925..76416313)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7019 Neighboring gene mitochondrial rRNA methyltransferase 3 Neighboring gene nucleoredoxin Neighboring gene STARR-seq mESC enhancer starr_30020 Neighboring gene STARR-seq mESC enhancer starr_30022 Neighboring gene STARR-seq mESC enhancer starr_30023 Neighboring gene STARR-seq mESC enhancer starr_30026 Neighboring gene STARR-positive B cell enhancer ABC_E9828 Neighboring gene STARR-positive B cell enhancer ABC_E3976 Neighboring gene STARR-positive B cell enhancer ABC_E7020 Neighboring gene active BCR-related gene Neighboring gene STARR-seq mESC enhancer starr_30035 Neighboring gene predicted gene 12341 Neighboring gene STARR-seq mESC enhancer starr_30037 Neighboring gene predicted gene, 53687

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. New testis-specific expressed genes on mouse Chromosome 11. Voss GC, et al. Mamm Genome, 1996 Feb. PMID 8835539
    2. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. Bauer MF, et al. FEBS Lett, 1999 Dec 24. PMID 10611480
    3. Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation. Cheong A, et al. Development, 2020 May 26. PMID 32376682, Free PMC Article
    4. RONIN Is an Essential Transcriptional Regulator of Genes Required for Mitochondrial Function in the Developing Retina. Poché RA, et al. Cell Rep, 2016 Feb 23. PMID 26876175, Free PMC Article
    5. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Homology

    Clone Names

    • 2610511O07Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mitochondrion targeting sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein insertion into mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein insertion into mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein insertion into mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of TIM22 mitochondrial import inner membrane insertion complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TIM22 mitochondrial import inner membrane insertion complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of TIM22 mitochondrial import inner membrane insertion complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    mitochondrial import inner membrane translocase subunit Tim22
    Names
    preprotein translocase
    translocase of inner mitochondrial membrane 22 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291161.1 → NP_001278090.1  mitochondrial import inner membrane translocase subunit Tim22 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks part of the 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK012130, BB724262, CA751902, CN710089
      Consensus CDS
      CCDS70245.1
      UniProtKB/TrEMBL
      B0QZS8
      Related
      ENSMUSP00000113238.2, ENSMUST00000120699.8
      Conserved Domains (1) summary
      pfam02466
      Location:22 → 131
      Tim17; Tim17/Tim22/Tim23/Pmp24 family

    2. NM_019818.5 → NP_062792.2  mitochondrial import inner membrane translocase subunit Tim22 isoform 1

      See identical proteins and their annotated locations for NP_062792.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest isoform (1).
      Source sequence(s)
      AK012130, BB724262, BY309364
      Consensus CDS
      CCDS25065.1
      UniProtKB/Swiss-Prot
      Q5SSL1, Q5SSL2, Q8QZU2, Q9CQ85, Q9JKW2
      Related
      ENSMUSP00000021203.7, ENSMUST00000021203.7
      Conserved Domains (1) summary
      pfam02466
      Location:69 → 186
      Tim17; Tim17/Tim22/Tim23/Pmp24 family

    3. NM_023355.2 → NP_075844.1  mitochondrial import inner membrane translocase subunit Tim22 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) is missing an exon in the coding region compared to transcript variant 1, which results in a frame-shift and a shorter isoform (2) with a distinct C-terminus compared to isoform 1. Variant 2 has transcript support, but the encoded isoform 2 is predicted, lacking in vivo protein support.
      Source sequence(s)
      AK012130, BB724262, BY309364
      UniProtKB/Swiss-Prot
      Q9CQ85

    RNA

    1. NR_111896.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate 5'terminal exon and an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AK012130, BB724262, CA751902, CN710089

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      76297751..76307139
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQ85.1 GenPept UniProtKB/Swiss-Prot:Q9CQ85

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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