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    Higd1a HIG1 domain family, member 1A [ Mus musculus (house mouse) ]

    Gene ID: 56295, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Higd1aprovided by MGI
    Official Full Name
    HIG1 domain family, member 1Aprovided by MGI
    Primary source
    MGI:MGI:1930666
    See related
    Ensembl:ENSMUSG00000038412 AllianceGenome:MGI:1930666
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hig1; HIMP1; 2210020B17Rik; 7420700H20Rik
    Summary
    Acts upstream of or within several processes, including cellular response to glucose starvation; negative regulation of release of cytochrome c from mitochondria; and positive regulation of protein serine/threonine kinase activity. Located in mitochondrial inner membrane and nucleus. Is expressed in cerebral cortex ventricular layer; cortical plate; and embryo. Orthologous to human HIGD1A (HIG1 hypoxia inducible domain family member 1A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 19.8), frontal lobe adult (RPKM 17.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Higd1a in Genome Data Viewer
    Location:
    9 F4; 9 72.67 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (121677623..121686862, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (121848557..121857796, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene hedgehog acyltransferase-like Neighboring gene coiled-coil domain containing 13 Neighboring gene predicted gene, 51698 Neighboring gene STARR-positive B cell enhancer ABC_E3869 Neighboring gene predicted gene, 47112 Neighboring gene predicted gene, 47113 Neighboring gene atypical chemokine receptor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HIGD1A links SIRT1 activity to adipose browning by inhibiting the ROS/DNA damage pathway.
      Title: HIGD1A links SIRT1 activity to adipose browning by inhibiting the ROS/DNA damage pathway.
    2. Mitochondrial HIGD1A inhibits hepatitis B virus transcription and replication through the cellular PNKD-NF-kappaB-NR2F1 nexus.
      Title: Mitochondrial HIGD1A inhibits hepatitis B virus transcription and replication through the cellular PNKD-NF-κB-NR2F1 nexus.
    3. Higd1a facilitates exercise-mediated alleviation of fatty liver in diet-induced obese mice.
      Title: Higd1a facilitates exercise-mediated alleviation of fatty liver in diet-induced obese mice.
    4. Higd1a plays positive roles in protecting cells from oxidative stress, and reactive oxygen species could induce Higd1a expression by upregulating PGC-1a and HIF-1a expressions.
      Title: Higd1a Protects Cells from Lipotoxicity under High-Fat Exposure.
    5. Important role in stress protective programs in mitochondria.
      Title: Pancreatic beta cells lack a low glucose and O2-inducible mitochondrial protein that augments cell survival.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to glucose starvation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to glucose starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to hypoxia IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial respirasome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of release of cytochrome c from mitochondria IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    HIG1 domain family member 1A, mitochondrial
    Names
    hypoxia induced gene 1
    hypoxia-inducible gene 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357837.1 → NP_001344766.1  HIG1 domain family member 1A, mitochondrial

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All six variants encode the same protein.
      Source sequence(s)
      AC165080, AI303276, AK018360, BE457620, CJ042199
      Consensus CDS
      CCDS40812.1
      UniProtKB/Swiss-Prot
      Q9JLR9
      UniProtKB/TrEMBL
      A0A1L1ST61, Q1XG81
      Conserved Domains (1) summary
      pfam04588
      Location:28 → 76
      HIG_1_N; Hypoxia induced protein conserved region

    2. NM_001357838.1 → NP_001344767.1  HIG1 domain family member 1A, mitochondrial

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
      Source sequence(s)
      AA414831, AI303276, AK018360, BE457620
      Consensus CDS
      CCDS40812.1
      UniProtKB/Swiss-Prot
      Q9JLR9
      UniProtKB/TrEMBL
      A0A1L1ST61, Q1XG81
      Related
      ENSMUSP00000149531.2, ENSMUST00000213124.2
      Conserved Domains (1) summary
      pfam04588
      Location:28 → 76
      HIG_1_N; Hypoxia induced protein conserved region

    3. NM_001357839.1 → NP_001344768.1  HIG1 domain family member 1A, mitochondrial

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
      Source sequence(s)
      AI303276, AK018360, BE457620, CJ042267
      Consensus CDS
      CCDS40812.1
      UniProtKB/Swiss-Prot
      Q9JLR9
      UniProtKB/TrEMBL
      A0A1L1ST61, Q1XG81
      Conserved Domains (1) summary
      pfam04588
      Location:28 → 76
      HIG_1_N; Hypoxia induced protein conserved region

    4. NM_001357840.1 → NP_001344769.1  HIG1 domain family member 1A, mitochondrial

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
      Source sequence(s)
      AI303276, AK018360, BE457620, BE689839
      Consensus CDS
      CCDS40812.1
      UniProtKB/Swiss-Prot
      Q9JLR9
      UniProtKB/TrEMBL
      A0A1L1ST61, Q1XG81
      Related
      ENSMUSP00000150726.2, ENSMUST00000215300.2
      Conserved Domains (1) summary
      pfam04588
      Location:28 → 76
      HIG_1_N; Hypoxia induced protein conserved region

    5. NM_001357841.1 → NP_001344770.1  HIG1 domain family member 1A, mitochondrial

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
      Source sequence(s)
      AI303276, AK018360, BE457620, BU851504
      Consensus CDS
      CCDS40812.1
      UniProtKB/Swiss-Prot
      Q9JLR9
      UniProtKB/TrEMBL
      A0A1L1ST61, Q1XG81
      Conserved Domains (1) summary
      pfam04588
      Location:28 → 76
      HIG_1_N; Hypoxia induced protein conserved region

    6. NM_019814.5 → NP_062788.1  HIG1 domain family member 1A, mitochondrial

      See identical proteins and their annotated locations for NP_062788.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
      Source sequence(s)
      AI303276, AK018360, BE457620
      Consensus CDS
      CCDS40812.1
      UniProtKB/Swiss-Prot
      Q9JLR9
      UniProtKB/TrEMBL
      A0A1L1ST61, Q1XG81
      Related
      ENSMUSP00000054881.7, ENSMUST00000060251.8
      Conserved Domains (1) summary
      pfam04588
      Location:28 → 76
      HIG_1_N; Hypoxia induced protein conserved region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      121677623..121686862 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JLR9.1 GenPept UniProtKB/Swiss-Prot:Q9JLR9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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