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    plekhg5a pleckstrin homology domain containing, family G (with RhoGef domain) member 5a [ Danio rerio (zebrafish) ]

    Gene ID: 562861, updated on 2-Nov-2024

    Summary

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    Official Symbol
    plekhg5aprovided by ZNC
    Official Full Name
    pleckstrin homology domain containing, family G (with RhoGef domain) member 5aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060503-766
    See related
    Ensembl:ENSDARG00000025902 AllianceGenome:ZFIN:ZDB-GENE-060503-766
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    syx; syx-a; plekhg5; si:ch211-15p9.7
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within angiogenesis; blood vessel endothelial cell migration; and gastrulation. Predicted to be active in axon; endocytic vesicle; and plasma membrane. Is expressed in axial vasculature; dorsal aorta; and intersegmental vessel. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate C and autosomal recessive distal hereditary motor neuronopathy 4. Orthologous to human PLEKHG5 (pleckstrin homology and RhoGEF domain containing G5). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See plekhg5a in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (24465397..24538554, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (24227781..24300895, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene dishevelled segment polarity protein 1b Neighboring gene uncharacterized LOC137496651 Neighboring gene matrix-remodelling associated 8a Neighboring gene uncharacterized LOC137496697 Neighboring gene uncharacterized LOC137496698 Neighboring gene synaptotagmin VIb

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Syx, a RhoA guanine exchange factor, is essential for angiogenesis in Vivo. Garnaas MK, et al. Circ Res, 2008 Sep 26. PMID 18757825, Free PMC Article
    2. The RhoA GEF Syx is a target of Rnd3 and regulated via a Raf1-like ubiquitin-related domain. Goh LL, et al. PLoS One, 2010 Aug 25. PMID 20811643, Free PMC Article
    3. pnp4a Is the Causal Gene of the Medaka Iridophore Mutant guanineless. Kimura T, et al. G3 (Bethesda), 2017 Apr 3. PMID 28258112, Free PMC Article
    4. The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells. Ernkvist M, et al. Blood, 2009 Jan 1. PMID 18824598, Free PMC Article
    5. The guanine nucleotide exchange factor Net1 facilitates the specification of dorsal cell fates in zebrafish embryos by promoting maternal β-catenin activation. Wei S, et al. Cell Res, 2017 Feb. PMID 27910850, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within angiogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within blood vessel endothelial cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within blood vessel endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endothelial cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family G member 5
    Names
    pleckstrin homology domain containing, family G (with RhoGef domain) member 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      24465397..24538554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009306046.4 → XP_009304321.1  pleckstrin homology domain-containing family G member 5 isoform X3

      UniProtKB/TrEMBL
      A0A0R4ISX1, A0A8M3B430
      Related
      ENSDARP00000137900.1, ENSDART00000171004.2
      Conserved Domains (4) summary
      cd13244
      Location:661 → 759
      PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
      pfam00169
      Location:663 → 757
      PH; PH domain
      pfam00621
      Location:418 → 604
      RhoGEF; RhoGEF domain
      pfam14776
      Location:30 → 104
      UNC-79; Cation-channel complex subunit UNC-79

    2. XM_021479837.2 → XP_021335512.1  pleckstrin homology domain-containing family G member 5 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PVI0
      Conserved Domains (2) summary
      cd00160
      Location:426 → 615
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13244
      Location:672 → 770
      PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain

    3. XM_009306045.4 → XP_009304320.1  pleckstrin homology domain-containing family G member 5 isoform X1

      UniProtKB/TrEMBL
      A0A8M3B6X2, F1R1Q2
      Related
      ENSDARP00000067077.7, ENSDART00000067078.8
      Conserved Domains (4) summary
      cd13244
      Location:683 → 781
      PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
      pfam00169
      Location:685 → 779
      PH; PH domain
      pfam00621
      Location:440 → 626
      RhoGEF; RhoGEF domain
      pfam14776
      Location:52 → 126
      UNC-79; Cation-channel complex subunit UNC-79

    4. XM_068224342.1 → XP_068080443.1  pleckstrin homology domain-containing family G member 5 isoform X4

      Related
      ENSDARP00000155684.1, ENSDART00000191936.1

    5. XM_009306048.4 → XP_009304323.1  pleckstrin homology domain-containing family G member 5 isoform X4

      See identical proteins and their annotated locations for XP_009304323.1

      UniProtKB/TrEMBL
      A0A2R8RLU7, A0A8M3AXP0
      Related
      ENSDARP00000148236.1, ENSDART00000189167.1
      Conserved Domains (3) summary
      cd13244
      Location:583 → 681
      PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
      pfam00169
      Location:585 → 679
      PH; PH domain
      pfam00621
      Location:340 → 526
      RhoGEF; RhoGEF domain

    6. XM_068224343.1 → XP_068080444.1  pleckstrin homology domain-containing family G member 5 isoform X5

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394820.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      1618..52886 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021472489.2 → XP_021328164.1  pleckstrin homology domain-containing family G member 5 isoform X8

      UniProtKB/TrEMBL
      A0A8M9PTC9

    2. XM_021472488.2 → XP_021328163.1  pleckstrin homology domain-containing family G member 5 isoform X7

      UniProtKB/TrEMBL
      A0A8M9PM84

    3. XM_021472487.2 → XP_021328162.1  pleckstrin homology domain-containing family G member 5 isoform X6

      UniProtKB/TrEMBL
      A0A8M9PAS1
      Conserved Domains (1) summary
      cl00155
      Location:189 → 246
      UBQ; Ubiquitin-like proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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